TRMT6 and FOXJ1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		TRMT6	FOXJ1
Name		tRNA methyltransferase 6 non-catalytic subunit	forkhead box J1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm TRNA (m1A) Methyltransferase Complex	Chromatin Nucleus
	Molecular Function	RNA Binding Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding
	Biological Process	MRNA Processing TRNA Processing TRNA Methylation	Negative Regulation Of Transcription By RNA Polymerase II Central Tolerance Induction Negative Regulation Of Germinal Center Formation Positive Regulation Of Central B Cell Tolerance Induction Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Humoral Immune Response Spermatogenesis Determination Of Left/right Symmetry Pattern Specification Process Brain Development Heart Development Intracellular Protein Localization Cell Projection Organization Actin Cytoskeleton Organization Regulation Of Epithelial Cell Differentiation Ciliary Basal Body Organization Negative Regulation Of Interleukin-6 Production Negative Regulation Of T Cell Differentiation In Thymus Axoneme Assembly Establishment Of Apical/basal Cell Polarity Metanephric Part Of Ureteric Bud Development Negative Regulation Of T Cell Proliferation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Cell Maturation Negative Regulation Of B Cell Activation Leukocyte Migration Cilium Assembly Lung Epithelium Development Epithelium Development Left/right Pattern Formation Glomerular Parietal Epithelial Cell Development Negative Regulation Of Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Lung Ciliated Cell Differentiation
Pathways		tRNA modification in the nucleus and cytosol	None
GWAS		ghrelin levels ( 33852427 ) Menarche and menopause (age at onset) ( 19448621 ) Uterine fibroids ( 31649266 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: FOXJ1 HHEX OGT TRMT61A	8 interacting genes: NMRAL1 OIP5 RFX2 RPUSD1 SLC37A3 THRA TRMT6 TWF2
Entrez ID		51605	2302
HPRD ID		13027	03798
Ensembl ID		ENSG00000089195	ENSG00000129654
Uniprot IDs		Q9UJA5	Q92949
PDB IDs		5CCB 5CCX 5CD1	Not available
GO Terms Enriched among Interactors		Glomerular Parietal Epithelial Cell Development Positive Regulation Of Central B Cell Tolerance Induction Regulation Of Translational Initiation Negative Regulation Of Translational Initiation Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Central Tolerance Induction Positive Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of B Cell Tolerance Induction Negative Regulation Of Germinal Center Formation Negative Regulation Of Cytoplasmic Translational Initiation MRNA (adenine-N1-)-methyltransferase Activity TRNA (adenine(58)-N1)-methyltransferase Activity Negative Regulation Of Developmental Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Translation Protein O-acetylglucosaminyltransferase Activity TRNA (m1A) Methyltransferase Complex Metanephric Part Of Ureteric Bud Development Transcription Cis-regulatory Region Binding Negative Regulation Of DNA-templated Transcription Ciliary Basal Body Organization Regulation Of Leukocyte Proliferation Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Regionalization Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Germinal Center Formation Eukaryotic Initiation Factor 4E Binding Negative Regulation Of Signal Transduction Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By Glucose Negative Regulation Of T Cell Differentiation In Thymus Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of MRNA Export From Nucleus Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Tolerance Induction Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway NSL Complex Left/right Pattern Formation Negative Regulation Of Transcription By Competitive Promoter Binding	None