AZIN1 and FANCC

Number of citations: 0 (PubMedID 14499622)
Data Source: BioGRID (two hybrid)

		AZIN1	FANCC
Name		antizyme inhibitor 1	FA complementation group C
Structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Fanconi Anaemia Nuclear Complex
	Molecular Function	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Ornithine Decarboxylase Activator Activity	Protein Binding
	Biological Process	Polyamine Biosynthetic Process Putrescine Biosynthetic Process From Arginine, Via Ornithine Negative Regulation Of Protein Catabolic Process Positive Regulation Of Polyamine Transmembrane Transport	DNA Repair Nucleotide-excision Repair DNA Damage Response Cellular Response To Oxidative Stress Interstrand Cross-link Repair Protein-containing Complex Assembly
Pathways		Regulation of ornithine decarboxylase (ODC)	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes PKR-mediated signaling
Diseases		None	Fanconi anemia
GWAS		Airway imaging phenotypes ( 26030696 ) Apolipoprotein A1 levels ( 32203549 ) Granulocyte count ( 27863252 ) HDL cholesterol levels ( 32203549 ) Immature fraction of reticulocytes ( 32888494 ) Mean platelet volume ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (agents acting on the renin-angiotensin system) ( 31015401 ) Neutrophil count ( 27863252 ) PR interval ( 32439900 ) QT interval ( 24952745 ) Serum alkaline phosphatase levels ( 33547301 ) Sum basophil neutrophil counts ( 27863252 ) Sum neutrophil eosinophil counts ( 27863252 ) TPE interval (resting) ( 32386560 ) Waist circumference adjusted for body mass index ( 28552196 ) White blood cell count ( 32888494 )	Birth weight ( 31043758 ) Hematocrit ( 32888494 ) Offspring birth weight ( 31043758 ) Polycystic ovary syndrome ( 26284813 )
Interacting Genes		7 interacting genes: ABCC2 ADSS1 BMAL1 CDKN2A FANCA FANCC KHDRBS1	54 interacting genes: APC AZIN1 BMPR1A BUB1 CAPN10 CCNA2 CCND1 CDK1 CTBP1 DLC1 DNAJB1 EGFR FANCA FANCD2 FANCE FANCF FANCG FBXW7 GSTP1 HSP90AA1 HSP90B1 HSPA1A HSPA4 HSPA8 IK KRAS KRT1 MEOX2 MLH3 MT-ATP6 MUTYH NRAS PDGFRL PIK3CA PMS2 POR PRDX3 PRPF31 PTPN12 PTPRJ RB1 RPL18 RPS3A SMAD4 SPTA1 SPTAN1 SRC STAT1 STMN1 STMN2 TCERG1 TGFBR2 USP14 ZBTB32
Entrez ID		51582	2176
HPRD ID		07443	01967
Ensembl ID		ENSG00000155096	ENSG00000158169
Uniprot IDs		A0A804HLH4 B3KTF6 O14977	A0A024R9N2 A0A087WW44 B4E3W2 Q00597
PDB IDs		4ZGZ	7KZP 7KZQ 7KZR 7KZS 7KZT 7KZV
GO Terms Enriched among Interactors		Fanconi Anaemia Nuclear Complex Cellular Senescence Ligase Inhibitor Activity Bilirubin Transmembrane Transporter Activity Bilirubin Transport Interstrand Cross-link Repair Grb2-Sos Complex	Cytosol Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Negative Regulation Of Supramolecular Fiber Organization Cellular Response To Stress Response To Stress Cellular Response To Growth Factor Stimulus Negative Regulation Of Cellular Component Organization Negative Regulation Of Cytoskeleton Organization Response To Hormone Response To Growth Factor Fanconi Anaemia Nuclear Complex Cellular Response To Peptide Hormone Stimulus ATP-dependent Protein Folding Chaperone Cellular Response To Hormone Stimulus Interstrand Cross-link Repair Nucleoplasm Regulation Of Supramolecular Fiber Organization Response To Steroid Hormone Regulation Of Organelle Organization Negative Regulation Of Programmed Cell Death Cadherin Binding Positive Regulation Of Cell Population Proliferation Nucleus Focal Adhesion Protein Folding Chaperone Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Regulation Of Multicellular Organismal Process DNA Repair Regulation Of Immune System Process Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Protein-containing Complex Disassembly DNA Damage Response Intracellular Signal Transduction Response To Peptide Hormone Regulation Of Cytoskeleton Organization Response To Lipid G1/S Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Macromolecule Metabolic Process Regulation Of Protein-containing Complex Assembly Negative Regulation Of Cell Cycle Phase Transition Cell Cycle G1/S Phase Transition Response To Unfolded Protein Regulation Of Cellular Component Organization Regulation Of Cell Cycle Phase Transition Regulation Of Protein Depolymerization