AZIN1 and ADSS1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		AZIN1	ADSS1
Description		antizyme inhibitor 1	adenylosuccinate synthase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	Catalytic Activity Ornithine Decarboxylase Activity Protein Binding Ornithine Decarboxylase Activator Activity	Nucleotide Binding Magnesium Ion Binding GTPase Activity Adenylosuccinate Synthase Activity Protein Binding GTP Binding Ligase Activity Phosphate Ion Binding Identical Protein Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Polyamine Biosynthetic Process Putrescine Biosynthetic Process From Arginine, Via Ornithine Negative Regulation Of Protein Catabolic Process Positive Regulation Of Polyamine Transmembrane Transport	Immune System Process Purine Nucleotide Metabolic Process Purine Nucleotide Biosynthetic Process AMP Biosynthetic Process Aspartate Metabolic Process Glutamine Metabolic Process Response To Muscle Activity Response To Starvation 'de Novo' AMP Biosynthetic Process AMP Salvage IMP Metabolic Process Cellular Response To Electrical Stimulus Cellular Response To Xenobiotic Stimulus
Pathways		Regulation of ornithine decarboxylase (ODC)	Purine ribonucleoside monophosphate biosynthesis
Drugs			Aspartic acid Hadacidin 6-O-Phosphoryl Inosine Monophosphate Guanosine-5'-Triphosphate Guanosine-5'-Diphosphate Adenylosuccinic acid Inosinic Acid Alanosine
Diseases
GWAS		Airway imaging phenotypes ( 26030696) Apolipoprotein A1 levels ( 32203549) Granulocyte count ( 27863252) HDL cholesterol levels ( 32203549) Immature fraction of reticulocytes ( 32888494) Mean platelet volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Neutrophil count ( 27863252) PR interval ( 32439900) QT interval ( 24952745) Serum alkaline phosphatase levels ( 33547301) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) TPE interval (resting) ( 32386560) Waist circumference adjusted for body mass index ( 28552196) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: ABCC2 ADSS1 BMAL1 CDKN2A FANCA FANCC KHDRBS1	2 interacting genes: AZIN1 LYAR
Entrez ID		51582	122622
HPRD ID		07443	12433
Ensembl ID		ENSG00000155096	ENSG00000185100
Uniprot IDs		A0A804HLH4 B3KTF6 O14977	B3KTV4 Q8N142
PDB IDs		4ZGZ
Enriched GO Terms of Interacting Partners?		Fanconi Anaemia Nuclear Complex Cellular Senescence Ligase Inhibitor Activity Bilirubin Transmembrane Transporter Activity Bilirubin Transport Interstrand Cross-link Repair Grb2-Sos Complex	Ornithine Decarboxylase Activity Ornithine Decarboxylase Activator Activity Positive Regulation Of Polyamine Transmembrane Transport Putrescine Biosynthetic Process From Arginine, Via Ornithine MRNA (adenine-N1-)-methyltransferase Activity TRNA (m1A) Methyltransferase Complex TRNA (adenine(58)-N1)-methyltransferase Activity Putrescine Biosynthetic Process Putrescine Metabolic Process Polyamine Biosynthetic Process Arginine Metabolic Process Polyamine Metabolic Process
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