PHF7 and RNF34

Number of citations: 44 (PubMedID 22493164)
Data Source: BioGRID (two hybrid)

		PHF7	RNF34
Name		PHD finger protein 7	ring finger protein 34
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane Nuclear Speck	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endomembrane System Membrane Nuclear Body Nuclear Speck
	Molecular Function	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding	P53 Binding Protein Binding Zinc Ion Binding Transferase Activity Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol Phosphate Binding
	Biological Process	Negative Regulation Of Osteoclast Proliferation	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Cold Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Oxygen Metabolic Process
Pathways		None	Regulation of TP53 Degradation Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Autism spectrum disorder or schizophrenia ( 28540026 ) Bipolar disorder ( 21926972 ) Parkinson's disease ( 28892059 ) Schizophrenia ( 23974872 ) Triglyceride levels ( 32154731 )	No GWAS studies recorded
Interacting Genes		18 interacting genes: APP ARIH2 DTX3L FBXL17 H3-4 IKBKG MAGEF1 MDM2 RNF111 RNF14 RNF34 SRPK1 TRIM26 TRIM41 UBE2D2 UBE2D4 USP1 USP15	17 interacting genes: APP APPBP2 DNAJA3 FLII IKBKG MAVS MKS1 NOD1 PHF7 RUBCN TRIM23 UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2F UBE2H
Entrez ID		51533	80196
HPRD ID		15127	10509
Ensembl ID		ENSG00000010318	ENSG00000170633
Uniprot IDs		A0A024R336 A8K856 Q9BWX1	A0A087WTM5 Q969K3
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Post-translational Protein Modification Protein Ubiquitination Protein Polyubiquitination Protein Modification Process Protein Modification By Small Protein Conjugation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Proteolysis Involved In Protein Catabolic Process Ubiquitin Protein Ligase Activity Protein Metabolic Process Macromolecule Catabolic Process Nucleus Protein K48-linked Ubiquitination Macromolecule Metabolic Process Ubiquitin-protein Transferase Activity Transferase Activity Catabolic Process Nucleoplasm Innate Immune Response Defense Response To Symbiont Defense Response To Other Organism Regulation Of Cellular Response To Stress Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Monoubiquitinated Protein Deubiquitination Response To Virus Regulation Of Signal Transduction Protein Autoubiquitination Zinc Ion Binding Response To Stress Response To Other Organism Protein-containing Complex Proteasomal Protein Catabolic Process Immune Response Regulation Of Cell Communication Regulation Of Signaling Defense Response To Virus Ubiquitin Ligase Complex Response To External Biotic Stimulus Intracellular Signal Transduction Regulation Of Signal Transduction By P53 Class Mediator Defense Response Immune System Process Protein K6-linked Ubiquitination Protein Catabolic Process Amyloid Fibril Formation Cytosol Ubiquitin Conjugating Enzyme Binding	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Protein Modification By Small Protein Conjugation Ubiquitin-protein Transferase Activity Post-translational Protein Modification Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Polyubiquitination Innate Immune Response Cytosol ATP Binding Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Catabolic Process Macromolecule Catabolic Process Defense Response To Symbiont Defense Response To Other Organism Protein Modification Process Proteasomal Protein Catabolic Process Proteolysis CARD Domain Binding Positive Regulation Of Interleukin-6 Production Nucleotide Binding Transferase Activity Positive Regulation Of Tumor Necrosis Factor Production Ubiquitin Ligase Complex Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Defense Response To Bacterium Immune System Process Protein Serine/threonine Kinase Binding Regulation Of Canonical NF-kappaB Signal Transduction Protein Catabolic Process Ubiquitin Protein Ligase Activity Regulation Of Autophagy Regulation Of Interleukin-6 Production Response To Other Organism Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Response To Bacterium Positive Regulation Of Myeloid Leukocyte Cytokine Production Involved In Immune Response Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Autophagy Immune Response Protein K11-linked Ubiquitination Protein Metabolic Process Regulation Of Innate Immune Response Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding