PDE9A and LINC02913

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		PDE9A	LINC02913
Name		phosphodiesterase 9A	long intergenic non-protein coding RNA 2913
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Membrane Ruffle Membrane Sarcolemma Cell Projection Perikaryon Perinuclear Region Of Cytoplasm	None
	Molecular Function	3',5'-cyclic-nucleotide Phosphodiesterase Activity 3',5'-cyclic-AMP Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Identical Protein Binding Metal Ion Binding 3',5'-cyclic-GMP Phosphodiesterase Activity	Protein Binding
	Biological Process	Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy CGMP Metabolic Process CGMP Catabolic Process Negative Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Neural Precursor Cell Proliferation	None
Pathways		cGMP effects	None
Drugs		Caffeine gamma-Glutamyl[S-(2-iodobenzyl)cysteinyl]glycine 3-isobutyl-1-methyl-7H-xanthine Trapidil	None
GWAS		Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Perceived unattractiveness to mosquitoes ( 28199695 )	No GWAS studies recorded
Interacting Genes		43 interacting genes: BAG3 CDC37 CLK1 CRY2 CYSRT1 ERCC1 FXR1 FXR2 GORASP2 HERC2 HIPK1 IQCB1 KANK2 KRT34 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-2 KRTAP12-3 KRTAP4-2 KRTAP5-9 KRTAP9-2 LAGE3 LINC02913 LMO2 NAA38 NFIL3 NOTCH2NLA PHYHIPL PRPF18 SDCBP SNRNP70 SULT1E1 TFAP4 TRIM32 TRPV6 UBD UTP23 WDR5 ZMYM5	2 interacting genes: PDE9A PSMA3
Entrez ID		5152	414318
HPRD ID		09115	10207
Ensembl ID		ENSG00000160191	Not available
Uniprot IDs		A0A0S2Z475 A0A0S2Z4A3 A0A0S2Z4T6 O76083	Not available
PDB IDs		2HD1 2YY2 3DY8 3DYL 3DYN 3DYQ 3DYS 3JSI 3JSW 3K3E 3K3H 3N3Z 3QI3 3QI4 4E90 4G2J 4G2L 4GH6 4Y86 4Y87 4Y8C 6A3N 6LZZ 7F0I 8BPY	Not available
GO Terms Enriched among Interactors		Intermediate Filament Keratin Filament Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Cytosol Identical Protein Binding Aggresome Assembly Cytosolic Ciliogenesis Protein Binding Pyrimidine Dimer Repair Positive Regulation Of Long-term Neuronal Synaptic Plasticity Inclusion Body Assembly	3',5'-cyclic-AMP Phosphodiesterase Activity CGMP Metabolic Process Cyclic Nucleotide Catabolic Process Negative Regulation Of Neural Precursor Cell Proliferation 3',5'-cyclic-GMP Phosphodiesterase Activity Positive Regulation Of Long-term Synaptic Potentiation CGMP Catabolic Process 3',5'-cyclic-nucleotide Phosphodiesterase Activity Negative Regulation Of CAMP/PKA Signal Transduction Proteasome Core Complex Proteasome Core Complex, Alpha-subunit Complex Cyclic Purine Nucleotide Metabolic Process Regulation Of Long-term Synaptic Potentiation Regulation Of CAMP/PKA Signal Transduction Positive Regulation Of Cardiac Muscle Hypertrophy Phosphoric Diester Hydrolase Activity Proteasome Complex Regulation Of Cardiac Muscle Hypertrophy Purine Ribonucleotide Catabolic Process Purine Nucleotide Catabolic Process Regulation Of Neural Precursor Cell Proliferation Ruffle Membrane Nucleotide Catabolic Process Catabolic Process Sarcolemma