DTL and TOB1

Number of citations: 33 (PubMedID 23066029)
Data Source: BioGRID (enzymatic study)

		DTL	TOB1
Name		denticleless E3 ubiquitin protein ligase adapter	transducer of ERBB2, 1
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Membrane Cul4A-RING E3 Ubiquitin Ligase Complex Cul4B-RING E3 Ubiquitin Ligase Complex Nuclear Membrane Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cytoplasm CCR4-NOT Complex
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Protein-macromolecule Adaptor Activity	Transcription Corepressor Activity Protein Binding Receptor Tyrosine Kinase Binding SMAD Binding
	Biological Process	Protein Polyubiquitination DNA Replication Ubiquitin-dependent Protein Catabolic Process Protein Monoubiquitination DNA Damage Response Mitotic G2 DNA Damage Checkpoint Signaling Response To UV Positive Regulation Of Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Ubiquitination Translesion Synthesis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Positive Regulation Of Protein Metabolic Process Regulation Of Cell Cycle	Negative Regulation Of Cell Population Proliferation Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of BMP Signaling Pathway Negative Regulation Of Osteoblast Differentiation Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Regulation Of SMAD Protein Signal Transduction Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay
Pathways		Recognition of DNA damage by PCNA-containing replication complex Neddylation	None
GWAS		Appendicular lean mass ( 33097823 ) Birth weight ( 27680694 31043758 ) Height ( 20881960 ) Large artery stroke ( 28265093 ) Nickel levels ( 26025379 ) Plateletcrit ( 32888494 )	No GWAS studies recorded
Interacting Genes		17 interacting genes: ATR CDK1 CDK2 CDKN1A CDT1 CHEK1 DDB1 KAT2A KMT5A PCNA POLD4 POLH TDG TOB1 TP53 UBE2D1 UBE2N	19 interacting genes: APP CDC7 CNOT7 CORO7 DTL ERBB2 MAPK1 MAPK9 MARCKS PABPC1 SCMH1 SETDB1 SMAD1 SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMAD9
Entrez ID		51514	10140
HPRD ID		17952	09273
Ensembl ID		ENSG00000143476	ENSG00000141232
Uniprot IDs		B4E0E6 F5GZ90 Q9NZJ0	P50616
PDB IDs		6QC0	2D5R 2Z15 5CI8 5CI9
GO Terms Enriched among Interactors		Regulation Of DNA Metabolic Process DNA Metabolic Process DNA Repair DNA Damage Response DNA Replication Regulation Of DNA Replication Cellular Response To Stress Negative Regulation Of Cell Cycle Process Cellular Response To UV DNA Damage Checkpoint Signaling Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cellular Response To Light Stimulus Nucleoplasm Chromatin Organization Replicative Senescence Negative Regulation Of Cell Cycle Phase Transition Nucleic Acid Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Regulation Of DNA Repair Chromatin Remodeling Regulation Of Cell Cycle Phase Transition Positive Regulation Of DNA Metabolic Process Signal Transduction In Response To DNA Damage Mitotic DNA Damage Checkpoint Signaling Response To UV Mitotic DNA Integrity Checkpoint Signaling Regulation Of Cell Cycle Process Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Radiation Chromosome, Telomeric Region Replication Fork Regulation Of Cellular Response To Stress Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of Mitotic Cell Cycle Nucleus Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Metabolic Process Fibroblast Proliferation Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of Macromolecule Metabolic Process Negative Regulation Of DNA Metabolic Process G2/M Transition Of Mitotic Cell Cycle Mitotic G2/M Transition Checkpoint Regulation Of Cell Cycle	Heteromeric SMAD Protein Complex I-SMAD Binding SMAD Protein Complex SMAD Protein Signal Transduction Response To Growth Factor Embryonic Pattern Specification Positive Regulation Of Nucleobase-containing Compound Metabolic Process Intracellular Signaling Cassette Cellular Response To Growth Factor Stimulus Co-SMAD Binding Ureteric Bud Development Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Transforming Growth Factor Beta Receptor Signaling Pathway Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Macromolecule Metabolic Process Tube Development Positive Regulation Of RNA Metabolic Process Transcription Regulator Complex Positive Regulation Of Metabolic Process Kidney Epithelium Development Enzyme-linked Receptor Protein Signaling Pathway Regulation Of MiRNA Transcription R-SMAD Binding BMP Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of MiRNA Metabolic Process Positive Regulation Of Biosynthetic Process DEAD/H-box RNA Helicase Binding Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Epithelium Development Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation Osteoblast Differentiation Primary MiRNA Processing Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Cytoplasm Positive Regulation Of MiRNA Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Chromatin Binding Tissue Development Cardiac Conduction System Development Positive Regulation Of MiRNA Metabolic Process Cytosol