LIMA1 and YWHAQ

Number of citations: 0 (PubMedID 36931259)
Data Source: BioGRID (affinity chromatography technology, pull down)

		LIMA1	YWHAQ
Name		LIM domain and actin binding 1	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Structure
GO Annotations	Cellular Component	Stress Fiber Ruffle Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Membrane Lamellipodium Brush Border Membrane Cleavage Furrow Cell Projection Anchoring Junction	Nucleus Cytoplasm Cytosol Focal Adhesion Membrane Protein-containing Complex Synapse Extracellular Exosome
	Molecular Function	Actin Binding Actin Monomer Binding Protein Binding Cadherin Binding Metal Ion Binding Actin Filament Binding Microtubule Stabilizing Activity	Protein Binding Protein Domain Specific Binding Identical Protein Binding Transmembrane Transporter Binding 14-3-3 Protein Binding
	Biological Process	Lipid Metabolic Process Steroid Metabolic Process Cholesterol Metabolic Process Cell Migration Intestinal Cholesterol Absorption Negative Regulation Of Cell Migration Negative Regulation Of Actin Filament Depolymerization Ruffle Organization Positive Regulation Of Actin Filament Bundle Assembly Cholesterol Homeostasis Actin Filament Bundle Assembly Negative Regulation Of Cilium Assembly Regulation Of Lamellipodium Organization	Protein Targeting Signal Transduction Small GTPase-mediated Signal Transduction Intracellular Protein Localization Substantia Nigra Development Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of DNA-templated Transcription
Pathways		None	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways
Drugs		None	Phenethyl Isothiocyanate
GWAS		Apolipoprotein B levels ( 32203549 ) Body fat distribution (arm fat ratio) ( 30664634 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Brain morphology (MOSTest) ( 32665545 ) Colorectal or endometrial cancer ( 26621817 ) LDL cholesterol levels ( 32203549 ) Low density lipoprotein cholesterol levels ( 32154731 )	Heart rate variability traits ( 22174390 ) Non-response to selective serotonin reuptake inhibitors and depression ( 27622933 )
Interacting Genes		10 interacting genes: APP CRYAA DAPK1 MFHAS1 PTEN UBC USP7 XIAP YWHAG YWHAQ	216 interacting genes: AARS2 ABL1 ACSL4 ADRB2 AGTR1 AHCY AKT1S1 ANXA1 ANXA2 AR ARHGAP10 ARHGEF16 ATP5F1A BAD BAX BCAP31 BCR BRAF CABIN1 CAPN3 CBL CBLL1 CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK14 CDK16 CDKN1A CDKN1B CFL1 CHAF1A CKM CLTC COPS4 CSE1L CSNK1A1 CSNK2A1 CTPS1 DAB2IP DCPS DDX1 DDX3X DHX9 DISC1 DNMT1 DYNC1H1 E2F1 EFNB1 EGFR EIF4A3 ENO1 EPB41 EPB41L1 EPB41L3 ESR1 ESR2 FASN FBLN1 FGR FSCN1 FSHR FXYD1 GAPDH GCN1 H2BC8 H4C14 HADHA HAT1 HAX1 HDAC7 HNRNPC HNRNPH1 HSPA1A HSPA8 HSPB1 HUS1 IARS2 ING1 ITCH ITGB4 KANK1 KCNK15 KCNK3 KCNK9 KIF5B KLC2 KLC3 KRT1 KRT9 LARP1 LARS2 LDHA LIMA1 LMNA LMNB1 LYST MAGOH MAP3K3 MAP3K5 MCM3 MDM4 MED1 MEF2D MPL MPRIP MRPS27 MST1R MTNR1B MTOR MYCBP2 NADK NCL NCOA1 NCOA3 NDE1 NEDD4L NFATC1 NFATC2 NFATC4 NFKB1 NIF3L1 NME7 NOLC1 NUMA1 PABPN1 PANK1 PDCD6 PDE3A PDE3B PDE4B PDK1 PDPK1 PDXK PFKFB2 PFKL PFN1 PGK1 PHLDB2 PI4KB PIK3C3 PIK3CB PKM PRDX1 PRKCQ PRKCZ PRKD1 PRKDC PRMT5 PSME3 RAI14 RCOR3 REM1 RFC1 RGS3 RGS7 RIPK2 RNASE2 RPL10A RPL15 RPL19 RPL7 RPLP0 RPLP2 RPS3 RUVBL2 SAMSN1 SH3BP2 SKIC8 SLC27A2 SLC8A1 SLC8A2 SLC8A3 SMAD9 SNRPE SOCS3 SPR SPTA1 SPTB SRSF3 SSBP1 SSX2IP SUMO2 TCP1 TERT THRA TLN1 TNF TNFAIP3 TPI1 TPR TRAF6 TRIM25 TRIM28 TRIM42 TSC1 TSC2 TUBA1A TUBA3C TUBB UBQLN4 UCP2 UCP3 ULK4 USP8 VARS1 WDR77 WTAP WWC2 WWP1 YAP1 YWHAG ZC3H13 ZHX2
Entrez ID		51474	10971
HPRD ID		09755	00886
Ensembl ID		ENSG00000050405	ENSG00000134308
Uniprot IDs		Q9UHB6	P27348
PDB IDs		2D8Y	2BTP 5IQP 6BCR 6BD2 6BQT 6KZG 6KZH
GO Terms Enriched among Interactors		Intracellular Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Protein Stabilization Identical Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Gene Expression Positive Regulation Of JNK Cascade Negative Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Apoptotic Process Response To Stress Negative Regulation Of Cell Communication Negative Regulation Of Biosynthetic Process Copper Ion Homeostasis Regulation Of JNK Cascade Regulation Of Protein Metabolic Process Negative Regulation Of Signaling Protein Serine/threonine Kinase Binding Regulation Of Protein Stability Cell Death Programmed Cell Death Regulation Of Transport Protein Modification Process Cytoplasm Regulation Of Response To Tumor Cell Positive Regulation Of Excitatory Postsynaptic Potential Reproductive Behavior Positive Regulation Of Catabolic Process Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Metabolic Process Neuron Projection Organization Protein Ubiquitination Protein Metabolic Process Regulation Of Intracellular Signal Transduction Negative Regulation Of Protein Localization To Nucleus Modulation Of Excitatory Postsynaptic Potential Regulation Of Signal Transduction Signal Transduction Protein Modification By Small Protein Conjugation Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway DAPK1-calmodulin Complex Positive Regulation Of Autophagic Cell Death Negative Regulation Of Synaptic Vesicle Clustering Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction TORC1 Signaling	Cytosol Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Intracellular Signal Transduction Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Multicellular Organismal Process Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Protein Metabolic Process ATP Binding Regulation Of Cellular Component Organization Regulation Of Primary Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Metabolic Process Nucleus Cadherin Binding Kinase Activity Negative Regulation Of Programmed Cell Death Regulation Of Developmental Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stress Nucleotide Binding Regulation Of Biological Quality Regulation Of Macromolecule Metabolic Process Positive Regulation Of Protein Metabolic Process Cell Cortex Cellular Response To Oxygen-containing Compound Response To Stress Protein-containing Complex Glucose Catabolic Process Organelle Organization Positive Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process ADP Metabolic Process RNA Binding Cellular Response To Lipid Positive Regulation Of Cell Communication Positive Regulation Of Signaling Extracellular Exosome Regulation Of Organelle Organization Positive Regulation Of Cell Population Proliferation Glycolytic Process Cellular Response To Hormone Stimulus