ATP5F1E and CYP17A1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ATP5F1E	CYP17A1
Name		ATP synthase F1 subunit epsilon	cytochrome P450 family 17 subfamily A member 1
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix Membrane Proton-transporting ATP Synthase Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Axon Neuronal Cell Body
	Molecular Function	Protein Binding Hydrolase Activity Proton-transporting ATP Synthase Activity, Rotational Mechanism	Monooxygenase Activity Steroid 17-alpha-monooxygenase Activity Iron Ion Binding Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Lyase Activity Oxygen Binding Heme Binding Metal Ion Binding
	Biological Process	ATP Biosynthetic Process Monoatomic Ion Transport Proton Motive Force-driven ATP Synthesis Proton Motive Force-driven Mitochondrial ATP Synthesis Proton Transmembrane Transport	Lipid Metabolic Process Steroid Biosynthetic Process Androgen Biosynthetic Process Glucocorticoid Biosynthetic Process Sex Differentiation Steroid Metabolic Process Cortisol Biosynthetic Process Hormone Metabolic Process Hormone Biosynthetic Process Progesterone Metabolic Process Olefinic Compound Metabolic Process
Pathways		Formation of ATP by chemiosmotic coupling Cristae formation	Androgen biosynthesis Glucocorticoid biosynthesis Defective CYP17A1 causes AH5
Drugs		None	NADH Progesterone Spironolactone Ketoconazole Levoketoconazole Abiraterone Cannabidiol Medical Cannabis Nabiximols
Diseases		None	Congenital adrenal hyperplasia (CAH) 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
GWAS		No GWAS studies recorded	Autism spectrum disorder or schizophrenia ( 28540026 ) Birth weight ( 31043758 ) Blood pressure ( 21572416 21909110 24001895 ) Brain morphology (MOSTest) ( 32665545 ) Colorectal cancer ( 26965516 ) Coronary artery disease ( 24262325 26343387 32469254 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Coronary heart disease ( 21378990 ) Diastolic blood pressure ( 28739976 27618452 25249183 27841878 ) Diastolic blood pressure (cigarette smoking interaction) ( 29455858 ) Hip circumference ( 25673412 ) Hypertension ( 25249183 31879980 30487518 ) Mean arterial pressure ( 26390057 27618448 30487518 ) Microalbuminuria ( 26631737 ) Myocardial infarction ( 33532862 26343387 ) Parkinson's disease ( 19915575 ) Prostate cancer ( 23535732 ) Pulse pressure ( 30487518 27841878 28739976 ) Schizophrenia ( 29483656 25056061 23974872 ) Sodium levels ( 29403010 ) Systolic blood pressure ( 30487518 28739976 27618447 28135244 27841878 27736895 27618452 19430479 26390057 25249183 21909115 19430483 ) Systolic blood pressure (cigarette smoking interaction) ( 29455858 ) Waist circumference ( 25673412 ) Waist-to-hip ratio adjusted for BMI ( 26426971 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )
Interacting Genes		2 interacting genes: AGTRAP CYP17A1	15 interacting genes: APC ATP5F1E BARX1 CDO1 CHEK2 CYB5A ERBB2 FZR1 HSP90AB1 IGF1R POR PTPRJ RPAIN STK11 TIGD7
Entrez ID		514	1586
HPRD ID		05856	01944
Ensembl ID		ENSG00000124172	ENSG00000148795
Uniprot IDs		P56381	P05093 Q1HB44
PDB IDs		8H9F 8H9J 8H9M 8H9Q 8H9S 8H9T 8H9U 8H9V 8KHF 8KI3	3RUK 3SWZ 4NKV 4NKW 4NKX 4NKY 4NKZ 5IRQ 5IRV 5UYS 6CHI 6CIR 6CIZ 6WR0 6WR1 6WW0 8FDA
GO Terms Enriched among Interactors		Cortisol Biosynthetic Process Androgen Biosynthetic Process Steroid 17-alpha-monooxygenase Activity Glucocorticoid Biosynthetic Process Cortisol Metabolic Process Angiotensin Type II Receptor Activity Progesterone Metabolic Process Steroid Hydroxylase Activity Glucocorticoid Metabolic Process Sex Differentiation C21-steroid Hormone Metabolic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Androgen Metabolic Process Steroid Hormone Biosynthetic Process Angiotensin-activated Signaling Pathway Endoplasmic Reticulum Membrane Ketone Biosynthetic Process Hormone Biosynthetic Process Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen Monooxygenase Activity Endoplasmic Reticulum Steroid Biosynthetic Process Ketone Metabolic Process Iron Ion Binding Heme Binding Olefinic Compound Metabolic Process Lyase Activity Regulation Of Blood Pressure Cytoplasmic Vesicle Membrane Cell Cortex Hormone Metabolic Process Regulation Of Biological Quality	Regulation Of Protein Modification Process Regulation Of Protein Kinase Activity Protein Kinase Regulator Activity Ruffle Membrane Regulation Of Kinase Activity Regulation Of Catalytic Activity Gamma-catenin Binding Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Protein Autophosphorylation Protein Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Phosphorylation Regulation Of Cold-induced Thermogenesis Regulation Of Protein Catabolic Process Regulation Of Cell Population Proliferation Phosphorylation Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Protein Serine/threonine Kinase Activity Regulation Of Phosphorylation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Protein Kinase Binding Regulation Of Cell Communication Negative Regulation Of Mitotic Cell Cycle Regulation Of Signaling Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphate-containing Compound Metabolic Process Response To Azide Cysteine Dioxygenase Activity Oligodendrocyte Differentiation Protein Kinase Activity Peptidyl-tyrosine Phosphorylation Carbohydrate Homeostasis Glucose Homeostasis Iron-cytochrome-c Reductase Activity Positive Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Nitric Oxide Dioxygenase NAD(P)H Activity Nitrate Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Transmembrane Receptor Protein Tyrosine Kinase Activity Regulation Of Microtubule-based Movement Regulation Of Programmed Cell Death Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Regulation Of Phosphorus Metabolic Process