KCNK9 and YWHAZ

Number of citations: 40 (PubMedID 12433946)
Data Source: HPRD (two hybrid, in vivo)

		KCNK9	YWHAZ
Name		potassium two pore domain channel subfamily K member 9	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
Structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Plasma Membrane Synaptic Vesicle Membrane Dendrite Cell Projection	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Vesicle Melanosome Extracellular Exosome Blood Microparticle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse
	Molecular Function	Voltage-gated Potassium Channel Activity Potassium Channel Activity Sodium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity Potassium Ion Leak Channel Activity Identical Protein Binding Metal Ion Binding Protein Heterodimerization Activity	RNA Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Transmembrane Transporter Binding Cadherin Binding Phosphoserine Residue Binding DNA-binding Transcription Factor Binding Protein Sequestering Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Visual Perception Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Regulation Of Resting Membrane Potential Cellular Response To Acidic PH Potassium Ion Transmembrane Transport Regulation Of Action Potential Firing Rate Potassium Ion Import Across Plasma Membrane Negative Regulation Of Aldosterone Secretion	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Respiratory System Process Protein Phosphorylation Protein Targeting Lysosome Organization Signal Transduction Synaptic Target Recognition Intracellular Protein Localization Lung Development Regulation Of Protein Stability Cellular Response To Nutrient Levels Tube Formation TORC1 Signaling Cellular Response To Glucose Starvation Negative Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Negative Regulation Of Innate Immune Response Establishment Of Golgi Localization ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Regulation Of Synapse Maturation Golgi Reassembly Antibacterial Innate Immune Response Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of TORC1 Signaling Regulation Of Lysosome Organization
Pathways		TWIK-releated acid-sensitive K+ channel (TASK) Phase 4 - resting membrane potential	Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors SARS-CoV-1 targets host intracellular signalling and regulatory pathways SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity
Drugs		Doxapram Halothane	Phenethyl Isothiocyanate
Diseases		Birk Barel mental retardation syndrome (BBMRS); Birk-Barel syndrome (BIBAS)	None
GWAS		Adiponectin levels ( 21700879 ) Cerebrospinal fluid t-tau:AB1-42 ratio ( 26252872 ) Cerebrospinal T-tau levels ( 26252872 ) Circulating phylloquinone levels ( 25411281 ) Low density lipoprotein cholesterol levels ( 30498476 ) Menarche (age at onset) ( 25231870 ) Response to lurasidone in schizophrenia ( 29730043 ) Urate levels in overweight individuals ( 25811787 ) Visceral adipose tissue ( 26480920 )	Adventurousness ( 30643258 ) Attention deficit hyperactivity disorder and conduct disorder ( 18951430 ) Body mass index ( 25673413 ) Chronotype ( 30696823 ) Cognitive decline rate in late mild cognitive impairment ( 26252872 ) General risk tolerance (MTAG) ( 30643258 ) High light scatter reticulocyte count ( 32888494 ) Interleukin-10 levels ( 22205395 )
Interacting Genes		7 interacting genes: SFN YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ	204 interacting genes: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARHGEF2 ATP5F1A ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CEP126 CEP131 CFL1 CGNL1 CLIC4 COP1 CPAP CRBN CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EP300 EPB41L1 EPB41L3 ERBB2 ERBB3 EXO1 FAM13B FHOD1 FNDC3B FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 GSK3B HDAC4 HDAC9 HMGN1 HSP90AA1 HSPA1A HSPA1B HSPB1 HSPB6 IGF1R IL9R ING1 INPP5A IRAG2 IRS1 IRS2 KANK1 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LATS2 LCP2 LIMK1 LNX1 MADD MAP2K5 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MTNR1A MYH9 NCAM2 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PCNT PDC PFKFB2 PIAS1 PPP1CC PPP1R14A PPP1R3D PRKACA PRKAR1A PRKCA PRKCD PRKCI PRKCZ PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RGS3 RIN1 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNAPIN SNX24 SORBS2 SQSTM1 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBC1D7 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UCHL5 UCP2 UCP3 USP8 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YAP1 YWHAE ZNF839
Entrez ID		51305	7534
HPRD ID		16167	03183
Ensembl ID		ENSG00000169427	ENSG00000164924
Uniprot IDs		Q9NPC2	D0PNI1 P63104
PDB IDs		3P1N 3P1O 3P1P 3P1Q 3P1R 3P1S 3SMK 3SML 3SMM 3SMN 3SMO 3SP5 3SPR 3UX0 4FR3 6GHP 8K1J 8K1Q 8K1V 8K1Z 9G9V 9G9W	1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL 4N7G 4N7Y 4N84 4WRQ 4ZDR 5D2D 5D3F 5EWZ 5EXA 5J31 5JM4 5M35 5M36 5M37 5NAS 5ULO 5WXN 5XY9 6EF5 6EJL 6EWW 6F08 6F09 6FN9 6FNA 6FNB 6FNC 6Q0K 6RLZ 6U2H 6XAG 6YMO 6YO8 6YOS 6ZFD 6ZFG 7D8H 7D8P 7D9V 7MFD 7MFE 7MFF 7Q16 7ZIT 8A9G 8AH2 8QDV 8WE2 8WF6 9FUM 9FVL
GO Terms Enriched among Interactors		Phosphoserine Residue Binding Protein Sequestering Activity Protein Domain Specific Binding Protein Targeting Establishment Of Protein Localization Intracellular Protein Localization Identical Protein Binding Transmembrane Transporter Binding Focal Adhesion Extracellular Exosome Phosphoprotein Binding Protein Kinase C Inhibitor Activity Substantia Nigra Development Neural Nucleus Development Cadherin Binding Melanosome Intracellular Signal Transduction Regulation Of Protein Localization Regulation Of Nucleocytoplasmic Transport Insulin-like Growth Factor Receptor Binding Regulation Of Intracellular Protein Transport Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Immune System Process Signal Transduction Negative Regulation Of Immune Response Negative Regulation Of Protein Localization Regulation Of Protein Export From Nucleus Regulation Of Transport Regulation Of Intracellular Transport Protein Phosphatase Inhibitor Activity Negative Regulation Of Protein Localization To Nucleus Cellular Response To Glucose Starvation Intracellular Signaling Cassette Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Immune Response Cytosol TORC1 Signaling Negative Regulation Of TORC1 Signaling Negative Regulation Of Protein Kinase Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Enzyme Binding Glucocorticoid Catabolic Process Negative Regulation Of Kinase Activity Regulation Of Monoatomic Ion Transport Negative Regulation Of Transport TOR Signaling Regulation Of Protein Transport Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Innate Immune Response Positive Regulation Of Intracellular Protein Transport	Cytoplasm Intracellular Signal Transduction Protein Kinase Activity Protein Serine Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Protein Phosphorylation Cytosol Regulation Of Intracellular Signal Transduction Phosphorylation Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Signal Transduction Positive Regulation Of Signal Transduction ATP Binding Intracellular Signaling Cassette Regulation Of Protein Modification Process Protein Modification Process Regulation Of Cellular Component Organization Regulation Of Programmed Cell Death Nucleotide Binding Regulation Of Protein Localization Negative Regulation Of Signaling Negative Regulation Of Cell Communication Regulation Of Apoptotic Process Positive Regulation Of Protein Metabolic Process Transferase Activity Positive Regulation Of Intracellular Signal Transduction Cellular Response To Stress Negative Regulation Of Programmed Cell Death Regulation Of Cell Population Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of Signal Transduction Cellular Response To Oxygen-containing Compound Regulation Of Phosphorus Metabolic Process Regulation Of Multicellular Organismal Process Protein Kinase Binding Phosphate-containing Compound Metabolic Process Positive Regulation Of Protein Localization Protein Metabolic Process Regulation Of Cell Cycle Cell Surface Receptor Signaling Pathway Response To Stress Protein-containing Complex MAPK Cascade Positive Regulation Of Cellular Component Organization