PCSK1 and PCSK1N

Number of citations: 0 (PubMedID 11435430)
Data Source: HPRD (in vitro)

		PCSK1	PCSK1N
Name		proprotein convertase subtilisin/kexin type 1	proprotein convertase subtilisin/kexin type 1 inhibitor
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane Transport Vesicle Secretory Granule Cytoplasmic Vesicle Secretory Granule Lumen Neuron Projection	Extracellular Region Extracellular Space Golgi Apparatus Trans-Golgi Network Secretory Granule
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding	Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding
	Biological Process	Proteolysis Cell-cell Signaling Protein Processing Peptide Hormone Processing Insulin Processing Peptide Biosynthetic Process	Response To Dietary Excess Neuropeptide Signaling Pathway Response To Cold Peptide Hormone Processing
Pathways		Peptide hormone biosynthesis Insulin processing Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) Synthesis, secretion, and deacylation of Ghrelin	None
GWAS		Adult body size ( 32376654 ) Blood protein levels ( 30072576 ) BMI at adiposity peak ( 31840077 ) Body mass index ( 22344219 29273807 28892062 25673413 24861553 ) Body mass index and fasting glucose (pairwise) ( 33619380 ) Fasting blood glucose ( 22581228 ) Fasting blood glucose (BMI interaction) ( 22581228 ) Fasting blood glucose adjusted for BMI ( 25625282 ) Fasting blood proinsulin levels ( 23263489 ) Fasting glucose ( 34059833 ) Glycemic traits (pregnancy) ( 23903356 ) Insulin-related traits (multivariate analysis) ( 32002517 ) Menarche (age at onset) ( 25231870 ) Proinsulin levels ( 21873549 ) Type 2 diabetes ( 32499647 ) Waist circumference ( 23966867 )	Type 2 diabetes ( 30718926 )
Interacting Genes		4 interacting genes: IAPP PCSK1N PMCH REN	2 interacting genes: PCSK1 RAD51
Entrez ID		5122	27344
HPRD ID		01201	02320
Ensembl ID		ENSG00000175426	ENSG00000102109
Uniprot IDs		P29120	Q9UHG2
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Feeding Behavior G Protein-coupled Receptor Signaling Pathway Peptide Hormone Processing Signaling Receptor Ligand Precursor Processing Signaling Receptor Binding Male Gonad Development Adherens Junction Disassembly Hormone Activity Neuropeptide Signaling Pathway Type 1 Melanin-concentrating Hormone Receptor Binding Melanin-concentrating Hormone Activity Signaling Cell Communication Cell-cell Junction Disassembly Negative Regulation Of Synaptic Transmission, Dopaminergic Gonad Development Cellular Response To Macrophage Colony-stimulating Factor Stimulus Signal Transduction Negative Regulation Of Mast Cell Activation Involved In Immune Response Developmental Process Involved In Reproduction Tyrosine Phosphorylation Of STAT Protein Extracellular Matrix-cell Signaling Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Kit Signaling Pathway Reproductive Structure Development Amylin Receptor 1 Signaling Pathway Amylin Receptor 3 Signaling Pathway Extracellular Region Amylin Receptor 2 Signaling Pathway Hormone Metabolic Process Juxtaglomerular Apparatus Development Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Protein Processing Renin-angiotensin Regulation Of Aldosterone Production Amylin Receptor Signaling Pathway Regulation Of Blood Volume By Renin-angiotensin Diapedesis Regulation Of Biological Quality Regulation Of Synaptic Transmission, Dopaminergic Negative Regulation Of Mast Cell Activation Response To Macrophage Colony-stimulating Factor Response To CGMP Calcitonin Family Receptor Signaling Pathway Drinking Behavior Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Response To Lipopolysaccharide Protein Maturation Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Response To Molecule Of Bacterial Origin Cellular Developmental Process	Mitotic Recombination-dependent Replication Fork Processing Response To Glucoside DNA Strand Exchange Activity Presynaptic Intermediate Filament Cytoskeleton DNA Strand Invasion Nuclear Ubiquitin Ligase Complex DNA Recombinase Assembly Cellular Response To Cisplatin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Response To Cisplatin Cellular Response To Camptothecin Response To Glycoside Insulin Processing Double-strand Break Repair Involved In Meiotic Recombination Cellular Response To Hydroxyurea Response To Hydroxyurea Lateral Element Telomere Maintenance Via Recombination Insulin Metabolic Process ATP-dependent DNA Damage Sensor Activity Single-stranded DNA Helicase Activity Mitotic Recombination Peptide Biosynthetic Process Regulation Of DNA Damage Checkpoint DNA Polymerase Binding Reciprocal Meiotic Recombination Response To X-ray Cellular Response To Gamma Radiation Telomere Maintenance Via Telomere Lengthening Nuclear Chromosome ATP-dependent Activity, Acting On DNA Condensed Chromosome Peptide Hormone Processing Replication Fork Processing Cellular Response To Alkaloid Meiosis I Homologous Recombination Interstrand Cross-link Repair Signaling Receptor Ligand Precursor Processing Condensed Nuclear Chromosome Male Germ Cell Nucleus Response To Gamma Radiation Chromosome Organization Involved In Meiotic Cell Cycle Peptide Metabolic Process Meiosis I Cell Cycle Process Cellular Response To Ionizing Radiation Meiotic Nuclear Division Regulation Of Double-strand Break Repair Via Homologous Recombination Identical Protein Binding Endopeptidase Activity