PCMT1 and RPIA

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology)

		PCMT1	RPIA
Name		protein-L-isoaspartate (D-aspartate) O-methyltransferase	ribose 5-phosphate isomerase A
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Extracellular Exosome Extracellular Vesicle	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein-L-isoaspartate (D-aspartate) O-methyltransferase Activity Protein Binding Methyltransferase Activity Transferase Activity Cadherin Binding	Ribose-5-phosphate Isomerase Activity Protein Binding Isomerase Activity Carbohydrate Binding Identical Protein Binding Monosaccharide Binding
	Biological Process	Protein Methylation Protein Repair Methylation	D-ribose Metabolic Process Pentose-phosphate Shunt Pentose-phosphate Shunt, Non-oxidative Branch
Pathways		Protein repair	RPIA deficiency: failed conversion of R5P to RU5P RPIA deficiency: failed conversion of RU5P to R5P Pentose phosphate pathway
Drugs		S-adenosyl-L-homocysteine	4-phospho-L-threonic acid
GWAS		Brain morphology (MOSTest) ( 32665545 ) Serum metabolite levels ( 33031748 ) Subcortical volume (MOSTest) ( 32665545 )	Blood protein levels ( 30072576 )
Interacting Genes		15 interacting genes: AGTR1 APOA1 APOE CCR2 CEBPA CHD3 CLP1 CREBBP CYSLTR2 DLG4 IQCB1 RPIA TAAR1 VKORC1 WEE2-AS1	20 interacting genes: ATPAF2 C14orf119 CENPP DDIT4L FOXP2 FXR1 FXR2 GORASP2 HSPB8 LNX1 NIF3L1 NTAQ1 PCMT1 PICK1 PTPN11 RNF208 SDCBP STK16 TXN2 VTA1
Entrez ID		5110	22934
HPRD ID		08908	01589
Ensembl ID		ENSG00000120265	ENSG00000153574
Uniprot IDs		A0A384MDK7 A0A3F2YNX8 B7Z972 F6S8N6 P22061	P49247
PDB IDs		1I1N 1KR5	Not available
GO Terms Enriched among Interactors		Protein-containing Complex Remodeling Positive Regulation Of Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Positive Regulation Of Phospholipid Efflux Positive Regulation Of Steroid Metabolic Process AMPA Glutamate Receptor Clustering Regulation Of Cholesterol Metabolic Process Phosphatidylcholine-sterol O-acyltransferase Activator Activity Lipoprotein Biosynthetic Process High-density Lipoprotein Particle Clearance Regulation Of Inflammatory Response Lipoprotein Particle Binding G Protein-coupled Receptor Signaling Pathway High-density Lipoprotein Particle Assembly Energy Homeostasis Regulation Of Defense Response Intracellular Signaling Cassette Chylomicron Phospholipid Efflux Regulation Of Cdc42 Protein Signal Transduction Neurotransmitter-gated Ion Channel Clustering Positive Regulation Of Phospholipid Transport Low-density Lipoprotein Particle Locomotory Exploration Behavior Low-density Lipoprotein Particle Remodeling Protein-containing Complex Organization Regulation Of Steroid Metabolic Process Reverse Cholesterol Transport Endocytic Vesicle Lumen Cholesterol Metabolic Process Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Remodeling Sterol Metabolic Process High-density Lipoprotein Particle Plasma Lipoprotein Particle Assembly Lipid Transporter Activity Cholesterol Transfer Activity Amyloid Precursor Protein Metabolic Process Regulation Of Lipid Transport Protein-lipid Complex Assembly Positive Regulation Of Lipid Metabolic Process G Protein-coupled Receptor Activity Positive Regulation Of Cholesterol Efflux Plasma Lipoprotein Particle Clearance Positive Regulation Of Cytosolic Calcium Ion Concentration Cholesterol Efflux Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Metabolic Process Lipid Homeostasis Exploration Behavior	Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Positive Regulation Of Long-term Neuronal Synaptic Plasticity Translation Regulator Activity Dentate Gyrus Development Regulation Of Long-term Neuronal Synaptic Plasticity