GAL and GALR1

Number of citations: 35 (PubMedID 8617199)
Data Source: HPRD (in vitro, in vivo)

		GAL	GALR1
Name		galanin and GMAP prepropeptide	galanin receptor 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Neuronal Cell Body	Plasma Membrane Membrane
	Molecular Function	Galanin Receptor Activity Hormone Activity Neuropeptide Hormone Activity Protein Binding Galanin Receptor Binding Type 1 Galanin Receptor Binding Type 2 Galanin Receptor Binding Type 3 Galanin Receptor Binding	G Protein-coupled Receptor Activity Galanin Receptor Activity Protein Binding Peptide Hormone Binding Neuropeptide Binding
	Biological Process	Neuropeptide Signaling Pathway Nervous System Development Feeding Behavior Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Protein Kinase A Signaling Insulin Secretion Regulation Of Glucocorticoid Metabolic Process Response To Insulin Response To Immobilization Stress Positive Regulation Of Apoptotic Process Response To Estrogen Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Lymphocyte Proliferation Positive Regulation Of Cortisol Secretion Positive Regulation Of Timing Of Catagen Parental Behavior Positive Regulation Of Large Conductance Calcium-activated Potassium Channel Activity	Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cortisol Secretion
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	Peptide ligand-binding receptors G alpha (i) signalling events
GWAS		Femoral neck section modulus ( 30888730 ) Height ( 28552196 ) Serum metabolite levels ( 33031748 )	A body shape index ( 34021172 ) Appendicular lean mass ( 33097823 ) Blood osmolality (transformed sodium) ( 28360221 ) DHEAS levels ( 34748635 ) Height ( 31562340 ) Metabolite levels ( 31628463 ) Obesity-related traits ( 23251661 ) Smoking initiation (ever regular vs never regular) ( 31089300 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		7 interacting genes: ASPH GALR1 GALR2 GPR151 SGTA UBQLN1 UBQLN2	2 interacting genes: GAL SNAPC5
Entrez ID		51083	2587
HPRD ID		00658	02657
Ensembl ID		ENSG00000069482	ENSG00000166573
Uniprot IDs		P22466	P47211
PDB IDs		7S3O 7S3Q 7S3R 7WQ3 7WQ4 7XBD 7XJJ 7XJK 8DHZ 8DJ4	7WQ3 7XJJ
GO Terms Enriched among Interactors		Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Proteolysis Galanin Receptor Activity Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Regulation Of Proteolysis Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Binding Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Peptide Hormone Binding Response To Endoplasmic Reticulum Stress Polyubiquitin Modification-dependent Protein Binding Regulation Of Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Macromolecule Metabolic Process G Protein-coupled Receptor Activity Regulation Of Protein Catabolic Process Positive Regulation Of Metabolic Process Galanin-activated Signaling Pathway Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Transmembrane Transporter Activity Regulation Of Monoatomic Ion Transmembrane Transporter Activity Autophagosome Autophagosome Assembly Proteasomal Protein Catabolic Process Neuropeptide Signaling Pathway Autophagosome Organization Peptidyl-aspartic Acid 3-dioxygenase Activity TRC Complex Negative Regulation Of G Protein-coupled Receptor Internalization Regulation Of Cellular Response To Stress Positive Regulation Of Catabolic Process Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Protein Catabolic Process Regulation Of Calcium Ion Transmembrane Transport Membrane Positive Regulation Of Cortisol Secretion BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Protein Metabolic Process Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Plasma Membrane Activation Of Store-operated Calcium Channel Activity Proteolysis Involved In Protein Catabolic Process	Type 2 Galanin Receptor Binding Type 3 Galanin Receptor Binding Positive Regulation Of Large Conductance Calcium-activated Potassium Channel Activity Type 1 Galanin Receptor Binding Galanin Receptor Binding Transcription Initiation At RNA Polymerase III Promoter SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III RNA Polymerase III General Transcription Initiation Factor Activity Regulation Of Natural Killer Cell Cytokine Production Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Positive Regulation Of Natural Killer Cell Mediated Immune Response To Tumor Cell Positive Regulation Of Mast Cell Activation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Positive Regulation Of Natural Killer Cell Cytokine Production Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Protein Kinase A Signaling Positive Regulation Of Timing Of Catagen Positive Regulation Of Hair Follicle Development Positive Regulation Of Cortisol Secretion Galanin Receptor Activity Regulation Of Glucocorticoid Metabolic Process Regulation Of Timing Of Catagen SnRNA Transcription Parental Behavior Positive Regulation Of Immune Response To Tumor Cell Regulation Of Mast Cell Activation Positive Regulation Of T Cell Receptor Signaling Pathway Regulation Of Hair Follicle Development Regulation Of Cell Activation Response To Immobilization Stress Positive Regulation Of Cation Channel Activity Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Response To Tumor Cell Neuropeptide Hormone Activity Regulation Of Hair Cycle Transcription By RNA Polymerase III Reproductive Behavior Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Potassium Ion Transport Regulation Of Hormone Metabolic Process Positive Regulation Of Natural Killer Cell Mediated Immunity RNA Polymerase II General Transcription Initiation Factor Activity Positive Regulation Of Immunoglobulin Mediated Immune Response Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Transporter Activity Natural Killer Cell Mediated Immunity Insulin Secretion