PCK1 and C1R

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		PCK1	C1R
Name		phosphoenolpyruvate carboxykinase 1	complement C1r
Structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Exosome	Extracellular Region Complement Component C1 Complex Extracellular Space Cell Surface Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Nucleotide Binding Magnesium Ion Binding Phosphoenolpyruvate Carboxykinase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity GTP Binding Kinase Activity Transferase Activity Lyase Activity Carboxy-lyase Activity Purine Nucleotide Binding Manganese Ion Binding Carboxylic Acid Binding Metal Ion Binding Protein Serine Kinase Activity (using GTP As Donor)	Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Molecular Sequestering Activity
	Biological Process	Glucose Metabolic Process Gluconeogenesis Oxaloacetate Metabolic Process NLS-bearing Protein Import Into Nucleus Lipid Metabolic Process Response To Bacterium Peptidyl-serine Phosphorylation Propionate Catabolic Process Response To Insulin Cellular Response To Insulin Stimulus SREBP-SCAP Complex Retention In Endoplasmic Reticulum Glucose Homeostasis Response To Starvation Positive Regulation Of Memory T Cell Differentiation Dicarboxylic Acid Metabolic Process Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Glyceraldehyde-3-phosphate Biosynthetic Process Glycerol Biosynthetic Process From Pyruvate Positive Regulation Of Lipid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Cellular Response To Potassium Ion Starvation Protein Maturation Hepatocyte Differentiation Cellular Response To Glucose Stimulus Cellular Response To Dexamethasone Stimulus Tricarboxylic Acid Metabolic Process	Activation Of Membrane Attack Complex Immune System Process Proteolysis Immune Response Complement Activation Complement Activation, Classical Pathway Opsonization Zymogen Activation Killing Of Cells Of Another Organism Innate Immune Response Protein Maturation
Pathways		Abacavir metabolism Transcriptional regulation of white adipocyte differentiation Gluconeogenesis FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs		Phosphoenolpyruvate 1-(2-Fluorobenzyl)-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 1-Allyl-3-Butyl-8-(N-Acetyl-4-Aminobenzyl)-Xanthine 5'-Guanylylmethylenebisphosphonate	Palivizumab Daclizumab Zinc Human C1-esterase inhibitor Conestat alfa Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases		None	Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Emphysema imaging phenotypes ( 26030696 ) Estimated glomerular filtration rate ( 31152163 31451708 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Prudent dietary pattern ( 28644415 ) Red blood cell count ( 32888494 ) Response to fenofibrate (adiponectin levels) ( 23149075 ) Serum alkaline phosphatase levels ( 31666285 ) Triglycerides ( 30275531 ) Type 2 diabetes ( 23300278 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: AKT1 APP C1R FBXO25 IKBKG INSIG1 INSIG2 UBR5	7 interacting genes: C1QA C1QB C1S CSNK2A1 EP300 PCK1 SERPING1
Entrez ID		5105	715
HPRD ID		02028	01954
Ensembl ID		ENSG00000124253	ENSG00000159403
Uniprot IDs		P35558	A0A3B3ISR2 B4DPQ0 P00736
PDB IDs		1KHB 1KHE 1KHF 1KHG 1M51 1NHX 2GMV	1APQ 1GPZ 1MD7 1MD8 2QY0 6F1C 6F1D 6F1H 6F39 9EKD 9EKE
GO Terms Enriched among Interactors		SREBP-SCAP Complex Retention In Endoplasmic Reticulum Negative Regulation Of SREBP Signaling Pathway Regulation Of SREBP Signaling Pathway Maintenance Of Protein Localization In Endoplasmic Reticulum Positive Regulation Of Cholesterol Biosynthetic Process NLS-bearing Protein Import Into Nucleus Positive Regulation Of Cholesterol Metabolic Process Regulation Of Cholesterol Biosynthetic Process ER-nucleus Signaling Pathway Positive Regulation Of Steroid Biosynthetic Process SREBP-SCAP-Insig Complex Positive Regulation Of Small Molecule Metabolic Process Negative Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Steroid Metabolic Process Maintenance Of Protein Localization In Organelle Regulation Of Cholesterol Metabolic Process Maintenance Of Protein Location In Cell Regulation Of Cellular Response To Stress Maintenance Of Protein Location Nuclear Transport Nucleocytoplasmic Transport Maintenance Of Location In Cell Cranial Suture Morphogenesis Maintenance Of Location Regulation Of Steroid Biosynthetic Process SREBP Signaling Pathway Cellular Response To Sterol Depletion Regulation Of Response To Endoplasmic Reticulum Stress Protein Maturation Response To Sterol Depletion Anoikis Regulation Of Small Molecule Metabolic Process Cellular Response To Insulin Stimulus Protein K29-linked Ubiquitination Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Regulation Of Steroid Metabolic Process Negative Regulation Of Signal Transduction Negative Regulation Of Small Molecule Metabolic Process Oxysterol Binding Protein Import Into Nucleus Negative Regulation Of Signaling Negative Regulation Of Cell Communication Import Into Nucleus Establishment Of Localization In Cell Craniofacial Suture Morphogenesis Regulation Of Ketone Metabolic Process Positive Regulation Of Lipid Metabolic Process Negative Regulation Of Fatty Acid Biosynthetic Process	Complement Component C1 Complex Symbiont Cell Surface Complement Component C1q Complex Complement Activation, Classical Pathway Regulation Of Immune Response IgM Binding Complement Activation Positive Regulation Of Immune Response Synapse Pruning Regulation Of Immune System Process IgG Binding Blood Microparticle Activation Of Immune Response Tricarboxylic Acid Metabolic Process Positive Regulation Of Immune System Process Humoral Immune Response Gluconeogenesis Phosphatidylserine Binding Protein Maturation Hexose Biosynthetic Process Pyruvate Metabolic Process Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Protein Serine Kinase Activity (using GTP As Donor) Collagen Trimer Immune Effector Process Negative Regulation Of Complement Activation, Lectin Pathway Extracellular Matrix Response To Stress Histone H2B Acetyltransferase Activity Acetylation-dependent Protein Binding Peptide Butyryltransferase Activity Peptide 2-hydroxyisobutyryltransferase Activity Protein Propionyltransferase Activity Histone H3K27 Acetyltransferase Activity Peptide Crotonyltransferase Activity Phosphoenolpyruvate Carboxykinase (GTP) Activity Phosphoenolpyruvate Carboxykinase Activity Glycerol Biosynthetic Process From Pyruvate Propionate Catabolic Process Response To Other Organism Protein Localization To Chromosome Carbohydrate Biosynthetic Process Vertebrate Eye-specific Patterning