SERPINA5 and ACR

Number of citations: 0 (PubMedID 7521127)
Data Source: BioGRID (pull down), HPRD (in vitro)

		SERPINA5	ACR
Name		serpin family A member 5	acrosin
Structure			No pdb structure
GO Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Extracellular Matrix Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Acrosomal Vesicle Extracellular Region Nucleus Golgi-associated Vesicle Protein-containing Complex Acrosomal Matrix
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Peptidase Inhibitor Activity Phosphatidylcholine Binding Acrosin Binding	Protease Binding DNA Binding Amidase Activity Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding D-mannose Binding Peptidase Activity Serine-type Peptidase Activity Zinc Ion Binding Hydrolase Activity Fucose Binding
	Biological Process	Lipid Transport Spermatogenesis Single Fertilization Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Seminal Clot Liquefaction	Acrosome Matrix Dispersal Proteolysis Activation Of Adenylate Cyclase Activity Single Fertilization Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Protein Catabolic Process Response To Steroid Hormone
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation	Acrosome Reaction and Sperm:Oocyte Membrane Binding
Drugs		Urokinase Drotrecogin alfa Tifuvirtide PPL-100	None
GWAS		Blood protein levels ( 30072576 ) Serum albumin levels ( 29403010 ) Serum total protein levels ( 29403010 )	No GWAS studies recorded
Interacting Genes		22 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD	3 interacting genes: SERPINA5 ZP2 ZP3
Entrez ID		5104	49
HPRD ID		03503	06342
Ensembl ID		ENSG00000188488	ENSG00000100312
Uniprot IDs		B4DDH1 P05154	P10323
PDB IDs		1LQ8 2HI9 2OL2 3DY0	Not available
GO Terms Enriched among Interactors		Zymogen Activation Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Blood Coagulation Hemostasis Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Plasminogen Activation Regulation Of Hemostasis Serine-type Peptidase Activity Serine-type Endopeptidase Activity Fibrinolysis Protein Processing Regulation Of Wound Healing Proteolysis Regulation Of Response To Wounding Regulation Of Body Fluid Levels Regulation Of Fibrinolysis Protein Maturation Peptidase Activity Extracellular Space Protein Metabolic Process Regulation Of Biological Quality Negative Regulation Of Fibrinolysis Extracellular Exosome Extracellular Region Negative Regulation Of Multicellular Organismal Process Macromolecule Metabolic Process Protein Activation Cascade Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Fibrinogen Complex Blood Coagulation, Fibrin Clot Formation Hydrolase Activity External Side Of Plasma Membrane Positive Regulation Of Heterotypic Cell-cell Adhesion Regulation Of Protein Maturation Positive Regulation Of Wound Healing Blood Coagulation, Common Pathway Platelet Activation Platelet Alpha Granule Negative Regulation Of Protein Maturation Positive Regulation Of Vasoconstriction Regulation Of Proteolysis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Secretory Granule Positive Regulation Of Fibrinolysis Regulation Of Protein Metabolic Process	Acrosin Binding Structural Constituent Of Egg Coat Egg Coat Single Fertilization Fertilization Regulation Of Acrosome Reaction Binding Of Sperm To Zona Pellucida Extracellular Matrix Sperm-egg Recognition Cell-cell Recognition Negative Regulation Of Reproductive Process Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-coagulation Factor XI Complex Protein C Inhibitor-PLAT Complex Cell Recognition Positive Regulation Of Type IV Hypersensitivity Positive Regulation Of Antral Ovarian Follicle Growth Seminal Clot Liquefaction Regulation Of Reproductive Process Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Egg Coat Formation Reproductive Process Platelet Dense Tubular Network Regulation Of Acrosomal Vesicle Exocytosis Negative Regulation Of Binding Of Sperm To Zona Pellucida Regulation Of Type IV Hypersensitivity Prevention Of Polyspermy Regulation Of Binding Of Sperm To Zona Pellucida Humoral Immune Response Mediated By Circulating Immunoglobulin Regulation Of Ovarian Follicle Development Positive Regulation Of Hypersensitivity Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Acrosome Reaction Regulation Of Fertilization Extracellular Region Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Acute Inflammatory Response To Antigenic Stimulus Oocyte Development Positive Regulation Of Calcium Ion-dependent Exocytosis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Platelet Alpha Granule Plasma Membrane Fusion