FOXP3 and IKZF4

Number of citations: 32 (PubMedID 19696312)
Data Source: BioGRID (pull down, two hybrid)

		FOXP3	IKZF4
Name		forkhead box P3	IKAROS family zinc finger 4
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex	Nucleus Nucleoplasm Nuclear Body Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Histone Acetyltransferase Binding Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding NF-kappaB Binding NFAT Protein Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding BHLH Transcription Factor Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II B Cell Homeostasis Negative Regulation Of Cytokine Production Myeloid Cell Homeostasis CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Lineage Commitment T Cell Mediated Immunity Tolerance Induction Tolerance Induction To Self Antigen T Cell Tolerance Induction Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Tolerance Induction Regulation Of T Cell Anergy Positive Regulation Of T Cell Anergy Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of T Cell Cytokine Production Positive Regulation Of Peripheral T Cell Tolerance Induction T Cell Anergy Chromatin Remodeling DNA-templated Transcription Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response Negative Regulation Of Cell Population Proliferation Response To Virus Gene Expression Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Establishment Of Endothelial Blood-brain Barrier Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Lipopolysaccharide Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Interleukin-4 Production Negative Regulation Of Interleukin-5 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-4 Production Negative Regulation Of CREB Transcription Factor Activity Positive Regulation Of CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Transforming Growth Factor Beta1 Production Positive Regulation Of Transforming Growth Factor Beta1 Production Immature T Cell Proliferation In Thymus Positive Regulation Of Immature T Cell Proliferation In Thymus CD4-positive, Alpha-beta T Cell Proliferation T Cell Proliferation T Cell Activation Negative Regulation Of T Cell Proliferation T Cell Homeostasis CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of DNA-binding Transcription Factor Activity Regulatory T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Activated T Cell Proliferation Alpha-beta T Cell Proliferation Negative Regulation Of Alpha-beta T Cell Proliferation Lymphocyte Proliferation Isotype Switching To IgE Isotypes Negative Regulation Of Isotype Switching To IgE Isotypes Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Response To Rapamycin Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Protein Homooligomerization
Pathways		RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) RUNX1 regulates transcription of genes involved in WNT signaling	None
Diseases		Permanent neonatal diabetes mellitus (PNDM) Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)	None
GWAS		Vitiligo ( 27723757 )	Age at first birth ( 34211149 ) Allergic disease (asthma, hay fever or eczema) ( 29785011 29083406 ) Alopecia areata ( 20596022 25608926 ) Anorexia nervosa ( 28494655 ) Asthma ( 32700739 31959851 31619474 21804548 ) Asthma or allergic disease (pleiotropy) ( 29785011 ) Autoimmune traits (pleiotropy) ( 30572963 ) Brain morphology (MOSTest) ( 32665545 ) Cognitive ability (MTAG) ( 29186694 ) Cognitive function ( 25644384 ) Eosinophil percentage of granulocytes ( 27863252 ) Eosinophil percentage of white cells ( 27863252 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Neutrophil percentage of granulocytes ( 27863252 ) Refractive error ( 32231278 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (ever vs never smokers) ( 30643258 ) Type 1 diabetes ( 21829393 25751624 18198356 ) Vitiligo ( 27723757 22561518 )
Interacting Genes		18 interacting genes: EP300 FOSB IKZF4 KAT8 KRTAP3-3 KRTAP6-2 KRTAP8-1 MDM2 NFAT5 NFATC2 NLK PRR20A PRR20B PRR20C PRR20D PRR20E RBPMS RUNX1	20 interacting genes: CDC7 CHD4 CSNK1D FHL2 FOXP3 HDAC2 IKZF1 IKZF2 IKZF3 IKZF5 MCRS1 MOB1A MOB3C NFKBIA NRG1 SIN3A SIN3B TCAF1 TCEA2 TXK
Entrez ID		50943	64375
HPRD ID		02242	05874
Ensembl ID		ENSG00000049768	ENSG00000123411
Uniprot IDs		Q9BZS1	F8VPL6 Q9H2S9
PDB IDs		3QRF 4WK8	2MA7
GO Terms Enriched among Interactors		Protein Propionyltransferase Activity DNA-binding Transcription Factor Binding Pre-mRNA Intronic Binding Histone H4 Acetyltransferase Activity Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Acetyltransferase Activity Transcription By RNA Polymerase II Calcineurin-NFAT Signaling Cascade Positive Regulation Of RNA Metabolic Process Histone Acetyltransferase Complex Protein-lysine-acetyltransferase Activity Negative Regulation Of RNA Metabolic Process Calcineurin-mediated Signaling Regulation Of DNA-templated Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity Positive Regulation Of Macromolecule Biosynthetic Process Histone Acetyltransferase Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process Intermediate Filament Positive Regulation Of Biosynthetic Process Regulation Of RNA Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Hemopoiesis DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via STAT Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Histone Crotonyltransferase Activity Response To Cocaine Response To Formaldehyde Cellular Response To Vitamin B1 Positive Regulation Of Gene Expression Cellular Response To Osmotic Stress Transcription Coactivator Binding Transcription Initiation-coupled Chromatin Remodeling Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Regulation Of Protein Processing Positive Regulation Of Alpha-beta T Cell Differentiation	Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription By RNA Polymerase II Nucleus Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Nucleoplasm Regulation Of Macromolecule Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Sin3-type Complex Transcription Corepressor Activity Regulation Of Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II NF-kappaB Binding Histone Deacetylase Binding Cellular Response To Dopamine Negative Regulation Of Macromolecule Metabolic Process Response To Dopamine Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Zinc Ion Binding NuRD Complex DNA Recombination Protein-containing Complex Chromatin Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Cellular Response To Catecholamine Stimulus Positive Regulation Of Macromolecule Metabolic Process Response To Catecholamine Chromatin Organization Regulation Of Cell Fate Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Stem Cell Population Maintenance Negative Regulation Of Cell Migration Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cell Motility Positive Regulation Of Cell Cycle G2/M Phase Transition Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Locomotion