PCBD1 and TFF3

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		PCBD1	TFF3
Name		pterin-4 alpha-carbinolamine dehydratase 1	trefoil factor 3
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Secretory Granule
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity Identical Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of DNA-templated Transcription	Regulation Of Glucose Metabolic Process Maintenance Of Gastrointestinal Epithelium
Pathways		Phenylalanine metabolism	Estrogen-dependent gene expression
Drugs		L-erythro-7,8-dihydrobiopterin	None
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient	None
GWAS		Blood protein levels ( 30072576 ) Chronotype ( 30696823 ) Immature fraction of reticulocytes ( 27863252 ) Microalbuminuria ( 26631737 ) Obesity-related traits ( 23251661 )	Spatial memory ( 31596458 )
Interacting Genes		53 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	4 interacting genes: PCBD1 SGTA UBQLN2 ZSCAN9
Entrez ID		5092	7033
HPRD ID		00523	02797
Ensembl ID		ENSG00000166228	ENSG00000160180
Uniprot IDs		P61457	Q07654
PDB IDs		Not available	1E9T 1PE3 6V1C
GO Terms Enriched among Interactors		Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Zinc Ion Binding Chromatin Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Frizzled Binding Epigenetic Regulation Of Gene Expression Metal Ion Binding Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nucleoplasm Positive Regulation Of Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TRNA Transcription By RNA Polymerase III TRNA Transcription Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Activity RSC-type Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Tetrahydrobiopterin Biosynthetic Process Negative Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Tetrahydrobiopterin Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRAPPII Protein Complex Pteridine-containing Compound Biosynthetic Process Tyrosine Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane TRAPP Complex Negative Regulation Of Receptor Internalization Early Endosome To Golgi Transport Regulation Of Clathrin-dependent Endocytosis Regulation Of Protein Catabolic Process Regulation Of Proteolysis