PCBD1 and PAH

Number of citations: 0 (PubMedID 11461190)
Data Source: BioGRID (two hybrid)

		PCBD1	PAH
Name		pterin-4 alpha-carbinolamine dehydratase 1	phenylalanine hydroxylase
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Cytosol
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Lyase Activity Identical Protein Binding	Catalytic Activity Monooxygenase Activity Phenylalanine 4-monooxygenase Activity Iron Ion Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Pteridine As One Donor, And Incorporation Of One Atom Of Oxygen Metal Ion Binding
	Biological Process	Tetrahydrobiopterin Biosynthetic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Positive Regulation Of DNA-templated Transcription	L-phenylalanine Catabolic Process Tyrosine Biosynthetic Process Amino Acid Biosynthetic Process Aromatic Amino Acid Metabolic Process Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine Catecholamine Biosynthetic Process
Pathways		Phenylalanine metabolism	Phenylketonuria Phenylalanine metabolism
Drugs		L-erythro-7,8-dihydrobiopterin	Phenylalanine Sapropterin Norepinephrine Quinonoid 7,8-Tetrahydrobiopterin beta-2-Thienyl-L-alanine L-erythro-7,8-dihydrobiopterin D-norleucine Droxidopa
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient	Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576 ) Chronotype ( 30696823 ) Immature fraction of reticulocytes ( 27863252 ) Microalbuminuria ( 26631737 ) Obesity-related traits ( 23251661 )	Bisphosphonate-associated atypical femoral fracture ( 31006051 ) Plasma free amino acid levels ( 30659259 ) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259 ) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259 ) Serum metabolite levels ( 31636271 ) Serum metabolite levels (CMS) ( 31636271 )
Interacting Genes		53 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	3 interacting genes: PCBD1 QDPR RPS24
Entrez ID		5092	5053
HPRD ID		00523	08943
Ensembl ID		ENSG00000166228	ENSG00000171759
Uniprot IDs		P61457	P00439
PDB IDs		Not available	1DMW 1J8T 1J8U 1KW0 1LRM 1MMK 1MMT 1PAH 1TDW 1TG2 2PAH 3PAH 4ANP 4PAH 5FII 5PAH 6HPO 6HYC 6N1K 6PAH
GO Terms Enriched among Interactors		Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Transcription By RNA Polymerase II Nucleus DNA Binding Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Metabolic Process Zinc Ion Binding Chromatin Binding Positive Regulation Of Macromolecule Biosynthetic Process Transcription Cis-regulatory Region Binding Frizzled Binding Epigenetic Regulation Of Gene Expression Metal Ion Binding Positive Regulation Of Biosynthetic Process Transcription Coactivator Activity Nucleoplasm Positive Regulation Of Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific TRNA Transcription By RNA Polymerase III TRNA Transcription Positive Regulation Of Gene Expression, Epigenetic Positive Regulation Of Macromolecule Metabolic Process Transcription Coregulator Activity Regulation Of Mitotic Cell Cycle DNA-binding Transcription Factor Activity RSC-type Complex Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G1/S Phase Transition	Tetrahydrobiopterin Metabolic Process Tetrahydrobiopterin Biosynthetic Process Pteridine-containing Compound Biosynthetic Process Diol Metabolic Process Pteridine-containing Compound Metabolic Process Aromatic Amino Acid Metabolic Process Response To G1 DNA Damage Checkpoint Signaling Dihydrobiopterin Metabolic Process 6,7-dihydropteridine Reductase Activity 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine L-amino Acid Metabolic Process Apoptosome NADH Binding Alpha-amino Acid Metabolic Process Amino Acid Metabolic Process Response To DNA Damage Checkpoint Signaling Alcohol Metabolic Process L-phenylalanine Catabolic Process Regulation Of Apoptotic DNA Fragmentation Cysteine-type Endopeptidase Activator Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Erythrocyte Homeostasis Cardiac Muscle Cell Apoptotic Process Striated Muscle Cell Apoptotic Process Tyrosine Metabolic Process Small Molecule Biosynthetic Process NADPH Binding Muscle Cell Apoptotic Process Aromatic Amino Acid Family Catabolic Process Translation Initiation Factor Binding Small Ribosomal Subunit Extracellular Exosome Myeloid Cell Homeostasis Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress ADP Binding Cytosolic Small Ribosomal Subunit Cytosol Carboxylic Acid Metabolic Process Organic Acid Metabolic Process Electron Transfer Activity Cellular Response To Transforming Growth Factor Beta Stimulus Heat Shock Protein Binding Amino Acid Biosynthetic Process