DHH and HHIP

Number of citations of the paper that reports this interaction (PubMedID 11435703)
0

Data Source:
HPRD (in vivo)

		DHH	HHIP
Description		desert hedgehog signaling molecule	hedgehog interacting protein
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Extracellular Space Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Membrane	Extracellular Region Cytoplasm Plasma Membrane Cell Surface Membrane Ciliary Membrane
	Molecular Function	Patched Binding Calcium Ion Binding Protein Binding Peptidase Activity Zinc Ion Binding Transferase Activity Hydrolase Activity Metal Ion Binding Cholesterol-protein Transferase Activity	Protein Binding Zinc Ion Binding Metal Ion Binding Hedgehog Family Protein Binding
	Biological Process	Osteoblast Differentiation Cell Fate Specification Proteolysis Smoothened Signaling Pathway Cell-cell Signaling Spermatid Development Regulation Of Gene Expression Protein Autoprocessing Male Sex Determination Response To Estradiol Leydig Cell Differentiation Myelination Response To Estrogen Positive Regulation Of Smoothened Signaling Pathway Regulation Of Steroid Biosynthetic Process Self Proteolysis	Signal Transduction Neuroblast Proliferation Animal Organ Morphogenesis Dorsal/ventral Pattern Formation Negative Regulation Of Signal Transduction Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway Skeletal System Morphogenesis Epithelial Tube Branching Involved In Lung Morphogenesis
Pathways		Class B/2 (Secretin family receptors) Hedgehog ligand biogenesis Release of Hh-Np from the secreting cell Release of Hh-Np from the secreting cell Ligand-receptor interactions Ligand-receptor interactions Hedgehog 'on' state Activation of SMO HHAT G278V doesn't palmitoylate Hh-Np Transcriptional regulation of testis differentiation	Ligand-receptor interactions
Drugs
Diseases		46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Bipolar disorder ( 31043756) Body mass index ( 25673413) Brain morphology (MOSTest) ( 32665545) Lumbar spine bone mineral density ( 22504420)	A body shape index ( 34021172) Adolescent idiopathic scoliosis ( 30395268) Appendicular lean mass ( 33097823) Birth weight ( 27680694 31043758) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 25673413) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease ( 28166215 30804561 25101718 22080838 20173748 19300482) Chronic obstructive pulmonary disease (moderate to severe) ( 24621683) Chronic obstructive pulmonary disease (severe) ( 24621683) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cortical surface area (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Diverticular disease ( 30177863) Emphysema distribution in smoking ( 27669027) Emphysema imaging phenotypes ( 26030696) Fasting insulin ( 34059833) Femoral neck bone mineral density ( 30172743) Femoral neck size ( 31053729) Haemorrhoidal disease ( 33888516) Heel bone mineral density ( 30598549) Height ( 32902719 31562340 34270706 28552196 18391951 18391950 18391952 19343178 20397748 20881960 23563607 25282103 25429064) Hip bone size ( 31053729) Hip circumference ( 25673412) Hip circumference adjusted for BMI ( 34021172 25673412 28552196) Hip index ( 34021172) Infant length ( 25281659) Kidney volume ( 34128465) Local histogram emphysema pattern ( 25006744) Lung function (FEV1) ( 28166213) Lung function (FEV1/FVC) ( 28166213 31453325) Lung function (FEV1/FVC) variance ( 31453325) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011) Malaria ( 31844061) Offspring birth weight ( 31043758) Pre bronchodilator FEV1/FVC ratio ( 26634245) Pre bronchodilator FEV1/FVC ratio in never-smokers ( 27612410) Pulmonary function ( 19300500 20010834 20010835) Pulmonary function (smoking interaction) ( 23284291) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 28448500 34021172 25673412) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) Waist-to-hip ratio adjusted for body mass index ( 28430825)
Interacting Genes		3 interacting genes: HHIP PTCH1 PTCH2	3 interacting genes: DHH IHH SHH
Entrez ID		50846	64399
HPRD ID		05664	06937
Ensembl ID		ENSG00000139549	ENSG00000164161
Uniprot IDs		O43323	Q96QV1
PDB IDs		2WFQ 2WFR 2WG3 3N1G 3N1Q	2WFT 2WFX 2WG3 2WG4 3HO3 3HO4 3HO5 7PGK 7PGL 7PGM 7PGN
Enriched GO Terms of Interacting Partners?		Hedgehog Family Protein Binding Negative Regulation Of Smoothened Signaling Pathway Hedgehog Receptor Activity Epidermal Cell Fate Specification Smoothened Binding Regulation Of Smoothened Signaling Pathway Positive Regulation Of Epidermal Cell Differentiation Positive Regulation Of Epidermis Development Cell Fate Determination Ciliary Membrane Positive Regulation Of Epithelial Cell Differentiation Regulation Of Epidermal Cell Differentiation Dorsal/ventral Pattern Formation Regulation Of Epidermis Development Cell Fate Specification Neural Plate Axis Specification Branching Morphogenesis Of An Epithelial Tube Epidermis Development Morphogenesis Of A Branching Epithelium Morphogenesis Of A Branching Structure Regulation Of Epithelial Cell Differentiation Response To Chlorate Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regionalization Tube Morphogenesis Morphogenesis Of An Epithelium Cell Proliferation Involved In Metanephros Development Patched Binding Mammary Gland Duct Morphogenesis Neural Tube Patterning Dendritic Growth Cone Pattern Specification Process Neural Tube Formation Metanephric Collecting Duct Development Tissue Morphogenesis Cell Proliferation Involved In Kidney Development Dorsal/ventral Neural Tube Patterning Negative Regulation Of Multicellular Organism Growth Collecting Duct Development Commissural Neuron Axon Guidance Hair Cycle Somite Development Prostate Gland Development Animal Organ Morphogenesis Negative Regulation Of Cell Division Cellular Response To Cholesterol Mammary Gland Epithelial Cell Differentiation Pharyngeal System Development	Cholesterol-protein Transferase Activity Patched Binding Self Proteolysis Protein Autoprocessing Positive Regulation Of Smoothened Signaling Pathway Intein-mediated Protein Splicing Smoothened Signaling Pathway Regulation Of Smoothened Signaling Pathway Cell Fate Specification Positive Regulation Of T Cell Differentiation In Thymus Negative Regulation Of T Cell Differentiation In Thymus Protein Processing Regulation Of Immature T Cell Proliferation In Thymus Somite Development Embryonic Digestive Tract Morphogenesis Smooth Muscle Tissue Development Regulation Of T Cell Differentiation In Thymus Protein Maturation Pancreas Development Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of Alpha-beta T Cell Differentiation Branching Involved In Blood Vessel Morphogenesis Regulation Of Mesenchymal Cell Proliferation Neuron Fate Commitment Peptidase Activity Negative Regulation Of Alpha-beta T Cell Activation Negative Regulation Of T Cell Differentiation Embryonic Skeletal System Development Embryonic Digit Morphogenesis Positive Regulation Of Alpha-beta T Cell Differentiation Vasculature Development Embryonic Pattern Specification Negative Regulation Of Lymphocyte Differentiation Heart Looping Cell-cell Signaling Calcium Ion Binding Embryonic Heart Tube Morphogenesis Signaling Golgi Membrane Negative Regulation Of T Cell Proliferation Cell Communication Positive Regulation Of Alpha-beta T Cell Activation Camera-type Eye Development Negative Regulation Of Lymphocyte Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Leukocyte Proliferation Embryonic Organ Morphogenesis Eye Development Epithelial Tube Morphogenesis Negative Regulation Of Eye Pigmentation
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