PARN and KHSRP

Number of citations: 0 (PubMedID 15175153)
Data Source: HPRD (in vitro, in vivo)

		PARN	KHSRP
Name		poly(A)-specific ribonuclease	KH-type splicing regulatory protein
Structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Nuclear Speck Postsynapse Glutamatergic Synapse	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Protein Kinase Binding Cation Binding Metal Ion Binding Telomerase RNA Binding	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein Folding Chaperone
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Box H/ACA Sno(s)RNA 3'-end Processing RNA Catabolic Process MRNA Catabolic Process Female Gamete Generation RNA Modification MiRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Telomerase RNA Stabilization LncRNA Processing Regulation Of Telomerase RNA Localization To Cajal Body PriRNA 3'-end Processing SiRNA 3'-end Processing	RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Protein Folding RNA Splicing MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Deadenylation of mRNA KSRP (KHSRP) binds and destabilizes mRNA	ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs		None	Resveratrol Artenimol
GWAS		Age at voice drop ( 27182965 ) Height ( 25429064 ) Male-pattern baldness ( 27182965 ) Menarche (age at onset) ( 27182965 ) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: FOXP1 KHSRP MAPKAPK2 MPHOSPH6 PALS2 SPATC1L SUMO2 UBC	17 interacting genes: A1CF APBB1 BACE1 CEBPA EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 MALAT1 NRON PARN PTBP2 SLC25A21-AS1 STK3 UBE2I
Entrez ID		5073	8570
HPRD ID		07250	10350
Ensembl ID		ENSG00000140694	ENSG00000088247
Uniprot IDs		A0A494C0Q2 A0A494C1K5 A0A494C1N1 B3KN69 O95453	M0R0C6 Q92945
PDB IDs		2A1R 2A1S 3CTR	2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T
GO Terms Enriched among Interactors		Protein Tag Activity Exosome (RNase Complex)	Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity CUT Catabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Metabolic Process TRNA Decay RNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Apoptotic Process SnRNA 3'-end Processing Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase Macromolecule Metabolic Process Nucleic Acid Binding MRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening SnRNA Processing Nuclear RNA Surveillance Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Surveillance Presynaptic Modulation Of Chemical Synaptic Transmission RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Microtubule Anchoring At Centrosome Spliceosomal Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Splicing PriRNA 3'-end Processing