PARN and MPHOSPH6

Number of citations: 47 (PubMedID 15231747)
Data Source: HPRD (two hybrid)

		PARN	MPHOSPH6
Name		poly(A)-specific ribonuclease	M-phase phosphoprotein 6
Structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Nuclear Speck Postsynapse Glutamatergic Synapse	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding MRNA 3'-UTR Binding Nuclease Activity Exonuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Hydrolase Activity Protein Kinase Binding Cation Binding Metal Ion Binding Telomerase RNA Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Box H/ACA Sno(s)RNA 3'-end Processing RNA Catabolic Process MRNA Catabolic Process Female Gamete Generation RNA Modification MiRNA Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Stability Positive Regulation Of Nucleobase-containing Compound Metabolic Process Poly(A)-dependent SnoRNA 3'-end Processing Telomerase RNA Stabilization LncRNA Processing Regulation Of Telomerase RNA Localization To Cajal Body PriRNA 3'-end Processing SiRNA 3'-end Processing	Maturation Of 5.8S RRNA RRNA Processing
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Deadenylation of mRNA KSRP (KHSRP) binds and destabilizes mRNA	Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
GWAS		Age at voice drop ( 27182965 ) Height ( 25429064 ) Male-pattern baldness ( 27182965 ) Menarche (age at onset) ( 27182965 ) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311 ) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311 )	Leukocyte telomere length ( 31171785 32109421 ) Lung adenocarcinoma ( 28604730 ) Nevus count or cutaneous melanoma ( 32341527 ) Obesity-related traits ( 23251661 ) Parkinson's disease motor subtype (tremor dominant vs postural instability/gait difficulty) ( 33987465 ) Seasonality and depression ( 30217971 )
Interacting Genes		8 interacting genes: FOXP1 KHSRP MAPKAPK2 MPHOSPH6 PALS2 SPATC1L SUMO2 UBC	28 interacting genes: AATF APLP1 ARHGAP18 CRYAA DNM2 DYNLRB1 EIF3G ERG28 EXOSC10 EXOSC3 EXOSC5 FTL GDF9 HSPB1 KNSTRN LRIF1 MTREX NUPR1 PARN RBM48 RPS20 SMARCA4 SNX9 THOP1 TLE1 TP53 UNC119 ZHX1
Entrez ID		5073	10200
HPRD ID		07250	16111
Ensembl ID		ENSG00000140694	ENSG00000135698
Uniprot IDs		A0A494C0Q2 A0A494C1K5 A0A494C1N1 B3KN69 O95453	H3BNT4 Q99547
PDB IDs		2A1R 2A1S 3CTR	6D6Q 6D6R 6H25
GO Terms Enriched among Interactors		Protein Tag Activity Exosome (RNase Complex)	Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process Exosome (RNase Complex) Nuclear Exosome (RNase Complex) 3'-5'-RNA Exonuclease Activity Nucleolar Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity SnRNA Metabolic Process MRNA Metabolic Process RNA 3'-end Processing RNA Catabolic Process RNA Binding Nuclear-transcribed MRNA Catabolic Process SnRNA Catabolic Process Nuclear RNA Surveillance CUT Catabolic Process RNA Surveillance Regulation Of Female Gonad Development Regulation Of Telomere Maintenance Via Telomerase RRNA Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process MRNA Catabolic Process U4 SnRNA 3'-end Processing Identical Protein Binding Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Macromolecule Biosynthetic Process Nucleolus RRNA 3'-end Processing Euchromatin TRNA Decay Nuclear MRNA Surveillance Nucleoplasm Negative Regulation Of Biosynthetic Process Regulation Of Telomerase RNA Localization To Cajal Body MDM2/MDM4 Family Protein Binding DNA Deamination Negative Regulation Of Metabolic Process Nucleobase-containing Compound Catabolic Process Response To Heat Regulation Of DNA Biosynthetic Process RRNA Processing Negative Regulation Of Gene Expression Maturation Of 5.8S RRNA Regulation Of Cell Growth Negative Regulation Of Macromolecule Metabolic Process Regulation Of Fibroblast Apoptotic Process