PAK3 and SYN1

Number of citations: 0 (PubMedID 12237306)
Data Source: HPRD (in vitro)

		PAK3	SYN1
Name		p21 (RAC1) activated kinase 3	synapsin I
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Postsynaptic Density Glutamatergic Synapse	Synaptonemal Complex Golgi Apparatus Cytoskeleton Synaptic Vesicle Postsynaptic Density Axon Dendrite Synaptic Vesicle Membrane Cytoplasmic Vesicle Cell Projection Cell Body Synapse Presynaptic Active Zone Schaffer Collateral - CA1 Synapse Presynapse Extrinsic Component Of Synaptic Vesicle Membrane
	Molecular Function	Nucleotide Binding Catalytic Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity SH3 Domain Binding Small GTPase Binding Metal Ion Binding Protein Serine Kinase Activity	Actin Binding Protein Binding ATP Binding Protein Kinase Binding Identical Protein Binding Calcium-dependent Protein Binding Cytoskeletal Protein-membrane Anchor Activity
	Biological Process	MAPK Cascade Stimulatory C-type Lectin Receptor Signaling Pathway Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Axonogenesis Cellular Response To Starvation Dendrite Development Cell Migration Regulation Of Actin Filament Polymerization Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Ephrin Receptor Signaling Pathway Regulation Of Axonogenesis Synapse Organization Dendritic Spine Development Dendritic Spine Morphogenesis Regulation Of Postsynapse Organization Regulation Of Actin Filament Organization	Chemical Synaptic Transmission Neurotransmitter Secretion Regulation Of Neurotransmitter Secretion Neuron Development Modulation Of Chemical Synaptic Transmission Synapse Organization Synaptic Vesicle Clustering Regulation Of Synaptic Vesicle Cycle Synaptic Vesicle Cycle Regulation Of Synaptic Vesicle Exocytosis
Pathways		Generation of second messenger molecules CD28 dependent Vav1 pathway Ephrin signaling Sema3A PAK dependent Axon repulsion Activation of RAC1 VEGFR2 mediated vascular permeability CD209 (DC-SIGN) signaling RHO GTPases activate PAKs RHO GTPases activate PAKs MAPK6/MAPK4 signaling CDC42 GTPase cycle RAC1 GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle	Serotonin Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Sensory processing of sound by inner hair cells of the cochlea
Drugs		Fostamatinib	Adenosine 5'-[gamma-thio]triphosphate
Diseases		Non-syndromic X-linked mental retardation	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		No GWAS studies recorded	No GWAS studies recorded
Interacting Genes		13 interacting genes: ARHGEF6 ARHGEF7 CDC42 GIT1 GIT2 MYO6 NCK1 PXN RAC1 RAF1 RHOJ SNCA SYN1	30 interacting genes: AMPH BIN1 BLM CAMK1 CAMK2G CDK5 CRK ERG GRB2 ITSN2 KAT5 MAPK3 NOS1 NOS1AP PAK1 PAK2 PAK3 PFN2 PIK3R1 PLCG1 PRKACA RASA1 RB1CC1 S100A1 SNCA SPTAN1 SRC SYN2 SYN3 VIM
Entrez ID		5063	6853
HPRD ID		02142	02433
Ensembl ID		ENSG00000077264	ENSG00000008056
Uniprot IDs		B2RCU6 O75914	P17600
PDB IDs		6FD3	Not available
GO Terms Enriched among Interactors		Regulation Of Protein-containing Complex Assembly Regulation Of Supramolecular Fiber Organization Lamellipodium Assembly Lamellipodium Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Supramolecular Fiber Organization Positive Regulation Of Cytoskeleton Organization Cell Cortex Lamellipodium Regulation Of Microtubule Polymerization Focal Adhesion Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Postsynapse Cell Junction Organization Cell Projection Supramolecular Fiber Organization Regulation Of Microtubule Polymerization Or Depolymerization Actin Filament Organization Positive Regulation Of Organelle Organization Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Lamellipodium Organization Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Plasma Membrane Bounded Cell Projection Assembly Enzyme-linked Receptor Protein Signaling Pathway Cell Projection Assembly Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Cellular Component Organization Regulation Of Lamellipodium Organization Ephrin Receptor Signaling Pathway Positive Regulation Of Stress Fiber Assembly Regulation Of Organelle Organization G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Substrate Adhesion-dependent Cell Spreading Cell-cell Junction Endocytosis Positive Regulation Of Actin Filament Bundle Assembly Positive Regulation Of Protein-containing Complex Assembly Protein Kinase Binding Signal Complex Assembly Intracellular Signaling Cassette Presynapse Thioesterase Binding Regulation Of Vesicle-mediated Transport Positive Regulation Of Protein Polymerization Regulation Of Microtubule-based Process Regulation Of Neurotransmitter Secretion Regulation Of Actin Filament Organization Small GTPase-mediated Signal Transduction Regulation Of Stress Fiber Assembly	Cytosol Regulation Of Cytoskeleton Organization Regulation Of Cellular Component Organization Vesicle-mediated Transport In Synapse Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Biological Quality Regulation Of Organelle Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Synaptic Vesicle Endocytosis Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Postsynaptic Density Regulation Of Cellular Localization Presynaptic Endocytosis Phosphotyrosine Residue Binding Ephrin Receptor Signaling Pathway Cytoplasm Regulation Of Protein-containing Complex Assembly Cellular Response To Lectin Stimulatory C-type Lectin Receptor Signaling Pathway Intracellular Signal Transduction Regulation Of Actin Filament Polymerization Regulation Of Defense Response Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Calcium Ion Transport Neurotrophin TRKA Receptor Binding Protein Serine Kinase Activity Protein Kinase Activity Actin Cytoskeleton Organization Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Regulation Of Calcium Ion Transmembrane Transport Regulation Of Cellular Component Size Cellular Response To Nutrient Levels Protein Serine/threonine Kinase Activity Glutamatergic Synapse Actin Filament-based Process Cytoskeleton Organization Regulation Of Developmental Process Regulation Of Neuron Projection Development Kinase Activity Regulation Of Innate Immune Response Regulation Of Transport Cell Junction Organization Response To Growth Factor Regulation Of Heart Contraction Positive Regulation Of Protein-containing Complex Assembly