GEMIN4 and FLAD1

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		GEMIN4	FLAD1
Name		gem nuclear organelle associated protein 4	flavin adenine dinucleotide synthetase 1
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Cajal Bodies	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane
	Molecular Function	Protein Binding Ribonucleoprotein Complex Binding	Nucleotide Binding Catalytic Activity FMN Adenylyltransferase Activity Protein Binding ATP Binding Transferase Activity Nucleotidyltransferase Activity Identical Protein Binding FAD Diphosphatase Activity
	Biological Process	Spliceosomal SnRNP Assembly RRNA Processing MRNA Processing RNA Splicing	FAD Biosynthetic Process Riboflavin Metabolic Process Flavin Adenine Dinucleotide Biosynthetic Process
Pathways		snRNP Assembly SARS-CoV-2 modulates host translation machinery	Vitamin B2 (riboflavin) metabolism
GWAS		Prostate cancer ( 23535732 )	Bipolar disorder ( 31043756 ) Body fat distribution (leg fat ratio) ( 30664634 ) Body fat distribution (trunk fat ratio) ( 30664634 ) Prostate cancer ( 23535732 ) Red blood cell count ( 32888494 ) Refractive error ( 32231278 )
Interacting Genes		57 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNASE2 RNF10 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35	21 interacting genes: ANXA7 APTX CDKN1A CLVS2 COPS3 CRABP2 DNM2 FXR1 GEMIN4 GRB7 L3MBTL3 NIF3L1 NUDT21 PRTFDC1 RCC1 REL SDCBP SMN1 TCF4 TK1 TRIM23
Entrez ID		50628	80308
HPRD ID		07370	17887
Ensembl ID		ENSG00000179409	ENSG00000160688
Uniprot IDs		I3L2C7 P57678 Q8WUM5 Q9HC39	Q8NFF5
PDB IDs		Not available	8ROM 8RON
GO Terms Enriched among Interactors		SMN-Sm Protein Complex Protein-RNA Complex Assembly Spliceosomal SnRNP Assembly U2 SnRNP 7-methylguanosine Cap Hypermethylation RNA Processing U4 SnRNP Methylosome Intermediate Filament Small Nuclear Ribonucleoprotein Complex RNA Splicing U1 SnRNP Tertiary Granule U5 SnRNP Presynaptic Dense Core Vesicle Exocytosis U2-type Prespliceosome Assembly U12-type Spliceosomal Complex MRNA Processing Perichromatin Fibrils U2-type Spliceosomal Complex RNA Polymerase II Complex Binding U2-type Catalytic Step 2 Spliceosome RNA Metabolic Process Positive Regulation Of Dendritic Cell Differentiation PICln-Sm Protein Complex Neuronal Dense Core Vesicle Exocytosis U1 SnRNP Binding Neutrophil Degranulation Transcription Elongation-coupled Chromatin Remodeling Keratin Filament RISC-loading Complex Dense Core Granule Exocytosis U4/U6 X U5 Tri-snRNP Complex RNA Binding Anaphase-promoting Complex Binding Calcium Ion-regulated Exocytosis Of Neurotransmitter RISC Complex Assembly MRNA Splicing, Via Spliceosome Spliceosomal Complex Assembly SiRNA Binding SMN Complex U2-type Precatalytic Spliceosome RNA Splicing, Via Transesterification Reactions Cytosol Locomotor Rhythm Ubiquitin Ligase Activator Activity Gemini Of Cajal Bodies Protein Binding Ribonucleoside Triphosphate Phosphatase Activity MRNA Metabolic Process	Nucleus Identical Protein Binding SMN Complex Gemini Of Cajal Bodies Cytoplasm Cellular Component Assembly SMN-Sm Protein Complex Protein-containing Complex Assembly MRNA 3'-UTR AU-rich Region Binding Mitotic Cell Cycle Phase Transition Regulation Of Cell Growth Nuclear Body Cyclin Binding Cell Cycle Phase Transition Protein Sequestering Activity Protein Heterodimerization Activity Lipid Binding Protein-containing Complex Organization Interleukin-5 Receptor Complex Spliceosomal SnRNP Assembly Ribonucleoprotein Complex Binding Positive Regulation Of Pro-B Cell Differentiation DNA-3'-diphospho-5'-guanosine Diphosphatase Single-strand Break-containing DNA Binding DNA 5'-adenosine Monophosphate Hydrolase Activity Nucleoside Metabolic Process