SERPINE1 and PLAU

Number of citations: 44 (PubMedID 2544876)
Data Source: HPRD (in vitro, in vivo)

		SERPINE1	PLAU
Name		serpin family E member 1	plasminogen activator, urokinase
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Serine Protease Inhibitor Complex Peptidase Inhibitor Complex	Extracellular Region Extracellular Space Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane Serine Protease Inhibitor Complex Protein Complex Involved In Cell-matrix Adhesion Serine-type Endopeptidase Complex
	Molecular Function	Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Peptidase Inhibitor Activity	Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Receptor Ligand Activity
	Biological Process	Angiogenesis Response To Bacterium Negative Regulation Of Plasminogen Activation Negative Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Negative Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Fibrinolysis Positive Regulation Of Angiogenesis Negative Regulation Of Proteolysis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Inflammatory Response Positive Regulation Of Coagulation Defense Response To Gram-negative Bacterium Negative Regulation Of Fibrinolysis Negative Regulation Of Vascular Wound Healing Negative Regulation Of Wound Healing Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotaxis Replicative Senescence Dentinogenesis Positive Regulation Of Odontoblast Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Integrin-mediated Signaling Pathway	Response To Hypoxia Proteolysis Chemotaxis Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Blood Coagulation Hemostasis Regulation Of Plasminogen Activation Negative Regulation Of Plasminogen Activation Smooth Muscle Cell Migration Regulation Of Smooth Muscle Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Cell Migration Plasminogen Activation Regulation Of Cell Adhesion Mediated By Integrin Urokinase Plasminogen Activator Signaling Pathway Regulation Of Cell Population Proliferation Fibrinolysis Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Fibrinolysis Negative Regulation Of Fibrinolysis Regulation Of Wound Healing Regulation Of Smooth Muscle Cell-matrix Adhesion Regulation Of Integrin-mediated Signaling Pathway
Pathways		Platelet degranulation BMAL1:CLOCK,NPAS2 activates circadian expression SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription ECM proteoglycans Dissolution of Fibrin Clot Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	Neutrophil degranulation Dissolution of Fibrin Clot
Drugs		Alteplase Urokinase Reteplase Anistreplase Tenecteplase Drotrecogin alfa Troglitazone Colforsin Fibrinolysin Copper Bucladesine	Amiloride 2-{2-hydroxy-[1,1'-biphenyl]-3-yl}-1H-1,3-benzodiazole-5-carboximidamide 2-(2-Hydroxy-5-Methoxy-Phenyl)-1h-Benzoimidazole-5-Carboxamidine 6-(N-Phenylcarbamyl)-2-Naphthalenecarboxamidine 2-(2-hydroxy-phenyl)-3H-benzoimidazole-5-carboxamidine 6-[N-(4-(Aminomethyl)Phenyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-3,4-Dihydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine CRA_10655 6-[N-(4-Ethyl-1,2,3,4-Tetrahydro-6-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 6-[N-(1-Isopropyl-1,2,3,4-Tetrahydro-7-Isoquinolinyl)Carbamyl]-2-Naphthalenecarboxamidine 7-Methoxy-8-[1-(Methylsulfonyl)-1h-Pyrazol-4-Yl]Naphthalene-2-Carboximidamide 6-[(Z)-Amino(Imino)Methyl]-N-[4-(Aminomethyl)Phenyl]-4-(Pyrimidin-2-Ylamino)-2-Naphthamide Benzamidine 4-Iodobenzo[B]Thiophene-2-Carboxamidine CRA_8696 Trans-6-(2-Phenylcyclopropyl)-Naphthalene-2-Carboxamidine 2-Amino-1H-benzimidazol-5-ol N-(1-adamantyl)-N'-(4-guanidinobenzyl)urea 6-Chloro-2-(2-Hydroxy-Biphenyl-3-Yl)-1h-Indole-5-Carboxamidine Thieno[2,3-B]Pyridine-2-Carboxamidine 8-(Pyrimidin-2-Ylamino)Naphthalene-2-Carboximidamide [2,4,6-Triisopropyl-Phenylsulfonyl-L-[3-Amidino-Phenylalanine]]-Piperazine-N'-Beta-Alanine Fibrinolysin 6-fluoro-2-(2-hydroxy-3-isobutoxy-phenyl)-1H-benzoimidazole-5-carboxamidine 6-FLUORO-2-[2-HYDROXY-3-(2-METHYL-CYCLOHEXYLOXY)-PHENYL]-1H-INDOLE-5-CARBOXAMIDINE N-(4-CARBAMIMIDOYL-3-CHORO-PHENYL)-2-HYDROXY-3-IODO-5-METHYL-BENZAMIDE 6-[(Z)-AMINO(IMINO)METHYL]-N-[3-(CYCLOPENTYLOXY)PHENYL]-2-NAPHTHAMIDE 1-[4-(2-oxo-2-phenylethyl)phenyl]guanidine (2R)-1-(2,6-dimethylphenoxy)propan-2-amine 4-(2-aminoethoxy)-N-(2,5-diethoxyphenyl)-3,5-dimethylbenzamide 4-(2-aminoethoxy)-N-(3-chloro-2-ethoxy-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide 4-(2-AMINOETHOXY)-3,5-DICHLORO-N-[3-(1-METHYLETHOXY)PHENYL]BENZAMIDE 4-(2-aminoethoxy)-N-(3-chloro-5-piperidin-1-ylphenyl)-3,5-dimethylbenzamide
Diseases		Inherited thrombophilia	None
GWAS		Blood protein levels ( 30072576 ) Nonunion in individuals with fractures ( 30680360 ) Plasma plasminogen activator levels ( 24578379 ) Plasminogen activator inhibitor type 1 levels (PAI-1) ( 22990020 )	Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143 ) Crohn's disease ( 28067908 )
Interacting Genes		25 interacting genes: ACTN4 ELANE F2 HSD17B11 IGFBP5 KLK2 KRT18 LMNA LRP1 LRP1B LRP2 MMP3 ORM1 PITX1 PLAT PLAU PLG SGTA SGTB TLX3 TMEM237 UBQLN1 UBQLN2 UBQLN4 VTN	25 interacting genes: ADAM28 ALAS1 BTK CEBPG CTSB CTSL ELAVL1 F2 HGF IGF2R KAT8 LRP2 MYC NID1 PDGFC PLAT PLAUR PLG SCAMP5 SERPINA5 SERPINB2 SERPINB6 SERPINE1 SERPINF2 ST14
Entrez ID		5054	5328
HPRD ID		01418	01883
Ensembl ID		ENSG00000106366	ENSG00000122861
Uniprot IDs		B7ZAB0 P05121	B4DNJ4 E7ET40 P00749 Q59GZ8
PDB IDs		1A7C 1B3K 1C5G 1DB2 1DVM 1DVN 1LJ5 1OC0 3CVM 3EOX 3PB1 3Q02 3Q03 3R4L 3UT3 4AQH 4G8O 4G8R 4IC0 5BRR 5ZLZ 6GWN 6GWP 6GWQ 6I8S 6ZRV 7AQF 7AQG 9PAI	1C5W 1C5X 1C5Y 1C5Z 1EJN 1F5K 1F5L 1F92 1FV9 1GI7 1GI8 1GI9 1GJ7 1GJ8 1GJ9 1GJA 1GJB 1GJC 1GJD 1KDU 1LMW 1O3P 1O5A 1O5B 1O5C 1OWD 1OWE 1OWH 1OWI 1OWJ 1OWK 1SC8 1SQA 1SQO 1SQT 1U6Q 1URK 1VJ9 1VJA 1W0Z 1W10 1W11 1W12 1W13 1W14 2FD6 2I9A 2I9B 2NWN 2O8T 2O8U 2O8W 2R2W 2VIN 2VIO 2VIP 2VIQ 2VIV 2VIW 2VNT 3BT1 3BT2 3IG6 3KGP 3KHV 3KID 3M61 3MHW 3MWI 3OX7 3OY5 3OY6 3PB1 3QN7 3U73 4DVA 4DW2 4FU7 4FU8 4FU9 4FUB 4FUC 4FUD 4FUE 4FUF 4FUG 4FUH 4FUI 4FUJ 4GLY 4H42 4JK5 4JK6 4K24 4MNV 4MNW 4MNX 4MNY 4OS1 4OS2 4OS4 4OS5 4OS6 4OS7 4X0W 4X1N 4X1P 4X1Q 4X1R 4X1S 4XSK 4ZHL 4ZHM 4ZKN 4ZKO 4ZKR 4ZKS 5HGG 5WXF 5WXO 5WXP 5WXQ 5WXR 5WXS 5WXT 5XG4 5YC6 5YC7 5Z1C 5ZA7 5ZA8 5ZA9 5ZAE 5ZAF 5ZAG 5ZAH 5ZAJ 5ZC5 6AG2 6AG3 6AG7 6AG9 6JYP 6JYQ 6L04 6L05 6NMB 6XVD 7DZD 7VM4 7VM5 7VM6 7VM7 7ZRR 7ZRT
GO Terms Enriched among Interactors		Negative Regulation Of Fibrinolysis Regulation Of Fibrinolysis Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Serine-type Endopeptidase Activity Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Fibrinolysis Serine-type Peptidase Activity Positive Regulation Of Wound Healing Regulation Of Proteolysis Regulation Of Blood Coagulation Negative Regulation Of Wound Healing Regulation Of Hemostasis Proteolysis Regulation Of Protein Metabolic Process Low-density Lipoprotein Particle Receptor Activity Regulation Of Wound Healing Negative Regulation Of Proteolysis TRC Complex Positive Regulation Of ERAD Pathway Peptidase Activity Extracellular Space Regulation Of Smooth Muscle Cell Migration Regulation Of Response To Wounding Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Regulation Of ERAD Pathway Regulation Of Cell Migration Endopeptidase Activity Regulation Of Cell Motility Trans-synaptic Signaling By BDNF Positive Regulation Of Protein Catabolic Process Regulation Of Protein Catabolic Process Regulation Of Locomotion Blood Coagulation Coagulation Neutrophil-mediated Killing Of Gram-negative Bacterium Hemostasis Positive Regulation Of Lysosomal Protein Catabolic Process Serine Protease Inhibitor Complex Biological Process Involved In Interaction With Symbiont Zymogen Activation Polyubiquitin Modification-dependent Protein Binding Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Response To Endoplasmic Reticulum Stress Extracellular Matrix Blood Microparticle Negative Regulation Of Multicellular Organismal Process	Regulation Of Fibrinolysis Fibrinolysis Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Negative Regulation Of Blood Coagulation Negative Regulation Of Hemostasis Negative Regulation Of Coagulation Extracellular Matrix Extracellular Space Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Negative Regulation Of Wound Healing Regulation Of Wound Healing Extracellular Region Regulation Of Response To Wounding Regulation Of Plasminogen Activation Serine Protease Inhibitor Complex Positive Regulation Of Wound Healing Regulation Of Multicellular Organismal Process Negative Regulation Of Plasminogen Activation Regulation Of Body Fluid Levels Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Multicellular Organismal Process Protease Binding Peptidase Inhibitor Activity External Side Of Plasma Membrane Proteoglycan Binding Regulation Of Protein Processing Regulation Of Cytokine Production Regulation Of Protein Maturation Extracellular Exosome Platelet Alpha Granule Lumen Serine-type Endopeptidase Activity Negative Regulation Of Gene Expression Peptidase Activity Negative Regulation Of Protein Processing Developmental Process Negative Regulation Of Protein Maturation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Cytokine Production Endopeptidase Activity Peptidase Inhibitor Complex Trans-synaptic Signaling By BDNF Blood Coagulation Coagulation Hemostasis Endolysosome Lumen Signaling Receptor Binding