PRDX1 and PRDX4

Number of citations: 0 (PubMedID 9388242)
Data Source: HPRD (in vivo, two hybrid, in vitro)

		PRDX1	PRDX4
Name		peroxiredoxin 1	peroxiredoxin 4
Structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome	Extracellular Region Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Secretory Granule Lumen Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Cadherin Binding Peroxiredoxin Activity Thioredoxin-dependent Peroxiredoxin Activity	Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Antioxidant Activity Oxidoreductase Activity Identical Protein Binding Peroxiredoxin Activity Molecular Adaptor Activity Molecular Sequestering Activity Thioredoxin-dependent Peroxiredoxin Activity
	Biological Process	Response To Reactive Oxygen Species Skeletal System Development Response To Oxidative Stress Canonical NF-kappaB Signal Transduction Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Regulation Of Stress-activated MAPK Cascade Erythrocyte Homeostasis Natural Killer Cell Mediated Cytotoxicity Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis Fibroblast Proliferation Regulation Of Non-canonical NF-kappaB Signal Transduction	Response To Oxidative Stress I-kappaB Phosphorylation Spermatogenesis Male Gonad Development Extracellular Matrix Organization Hydrogen Peroxide Catabolic Process Cell Redox Homeostasis Protein Maturation Reactive Oxygen Species Metabolic Process Cellular Oxidant Detoxification Negative Regulation Of Male Germ Cell Proliferation
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models NFE2L2 regulating anti-oxidant/detoxification enzymes	Neutrophil degranulation
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
GWAS		Body mass index ( 26426971 ) Hemoglobin ( 32888494 )	No GWAS studies recorded
Interacting Genes		31 interacting genes: ABL1 ADH5 ADRB2 AXIN2 CALM1 CCR4 CDK1 CEBPA CLEC4G EGFR GAPDH IRAK1 IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ	27 interacting genes: A1BG ALG12 APOB CDR1 CFHR1 CFHR3 CLIC1 CYP27A1 DUSP23 GLTPD2 HDAC6 LBP MAP4K2 MT-CO1 NR4A1 OTUD1 PLG PRDX1 PRDX3 PTBP2 RCHY1 SULT2A1 SUMO4 TBXA2R TTF2 UBC VTN
Entrez ID		5052	10549
HPRD ID		01458	05935
Ensembl ID		ENSG00000117450	ENSG00000123131
Uniprot IDs		A0A384NPQ2 Q06830	Q13162 V9HW63
PDB IDs		2RII 3HY2 4XCS 7LJ1 7WET 7WEU 8X71 8X73 8Z54 8Z55 8Z56 8Z57 8Z58 9B7A	2PN8 3TJB 3TJF 3TJG 3TJJ 3TJK 3TKP 3TKQ 3TKR 3TKS 4RQX 5HQP 8EKW 8EKY
GO Terms Enriched among Interactors		Response To Lipid Regulation Of Multicellular Organismal Process Intracellular Signal Transduction Intracellular Signaling Cassette Cellular Response To Oxygen-containing Compound Positive Regulation Of Metabolic Process Positive Regulation Of Biosynthetic Process Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Signaling MAPK Cascade Positive Regulation Of Macromolecule Metabolic Process Response To Stress Positive Regulation Of Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Protein-containing Complex Regulation Of Intracellular Signal Transduction Positive Regulation Of Gene Expression Regulation Of Signal Transduction Molecular Adaptor Activity Negative Regulation Of Signaling Negative Regulation Of Cell Communication Cellular Response To Lipid Negative Regulation Of Metabolic Process Regulation Of Cell Cycle Regulation Of DNA Metabolic Process Chromosome Organization Nucleus ERK1 And ERK2 Cascade Regulation Of Cell Population Proliferation Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Multicellular Organismal Process Regulation Of Autophagy Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Cycle Process Response To Cytokine Leukocyte Activation Response To Peptide Negative Regulation Of TORC1 Signaling Enzyme Binding Regulation Of Cell Communication Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Leukocyte Activation Involved In Immune Response Regulation Of Macromolecule Biosynthetic Process Regulation Of Growth Cell Activation Involved In Immune Response Positive Regulation Of DNA Metabolic Process	Blood Microparticle Positive Regulation Of Blood Coagulation Positive Regulation Of Coagulation Thioredoxin-dependent Peroxiredoxin Activity Peroxiredoxin Activity Thioredoxin Peroxidase Activity Extracellular Space Complement Component C3b Binding Detection Of Molecule Of Bacterial Origin Response To Oxidative Stress Positive Regulation Of Wound Healing Negative Regulation Of Fibrinolysis Regulation Of Hemostasis Regulation Of Blood Coagulation Protein Tag Activity Regulation Of Fibrinolysis Hydrogen Peroxide Catabolic Process Extracellular Exosome Mature Chylomicron Sterol Metabolic Process Cholesterol Metabolic Process Response To External Biotic Stimulus Cholesterol 26-hydroxylase Activity Cholestanetetraol 26-dehydrogenase Activity Bile Acid Metabolic Process Alcohol Catabolic Process Lipopolysaccharide Binding Detection Of Biotic Stimulus Response To Lipopolysaccharide Peroxidase Activity Antioxidant Activity Hydrogen Peroxide Metabolic Process Regulation Of Wound Healing Thromboxane Receptor Activity Thromboxane A2 Signaling Pathway Thromboxane A2 Receptor Activity Symbiont-containing Vacuole Polyubiquitinated Misfolded Protein Transport Positive Regulation Of Cholangiocyte Proliferation NADH-dependent Peroxiredoxin Activity Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol Alpha-1,6-mannosyltransferase Activity Biological Process Involved In Interaction With Symbiont Response To Molecule Of Bacterial Origin