P2RY1 and NHERF2

Number of citations: 25 (PubMedID 9671706)
Data Source: HPRD (in vitro)

		P2RY1	NHERF2
Name		purinergic receptor P2Y1	NHERF family PDZ scaffold protein 2
Structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Cell Surface Postsynaptic Density Membrane Basolateral Plasma Membrane Apical Plasma Membrane Dendrite Cell Body Postsynaptic Membrane Presynaptic Active Zone Membrane Glutamatergic Synapse	Nucleus Plasma Membrane Focal Adhesion Endomembrane System Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding G Protein-coupled ADP Receptor Activity G Protein-coupled Receptor Activity Protein Binding ATP Binding Signaling Receptor Regulator Activity A1 Adenosine Receptor Binding Signaling Receptor Activity ADP Binding G Protein-coupled Purinergic Nucleotide Receptor Activity G Protein-coupled ATP Receptor Activity Protein Heterodimerization Activity Scaffold Protein Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Phosphatase Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Cadherin Binding Molecular Adaptor Activity
	Biological Process	G Protein-coupled Adenosine Receptor Signaling Pathway Monoatomic Ion Transport Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Hemostasis Glial Cell Migration Regulation Of Cell Shape Response To Mechanical Stimulus Negative Regulation Of Norepinephrine Secretion Signal Transduction Involved In Regulation Of Gene Expression Platelet Activation Positive Regulation Of Inositol Trisphosphate Biosynthetic Process G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Eating Behavior Positive Regulation Of Monoatomic Ion Transport Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Secretion Establishment Of Localization In Cell Positive Regulation Of Penile Erection Positive Regulation Of ERK1 And ERK2 Cascade Response To Growth Factor Cellular Response To ATP Cellular Response To Purine-containing Compound Protein Localization To Plasma Membrane Relaxation Of Muscle Blood Vessel Diameter Maintenance Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Synaptic Vesicle Exocytosis	Protein-containing Complex Assembly Protein Localization To Plasma Membrane
Pathways		G alpha (q) signalling events P2Y receptors ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1	None
Drugs		Promethazine	None
GWAS		Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437 ) Chronotype ( 30696823 ) Immune reponse to smallpox (secreted IL-2) ( 22610502 ) Metabolite levels ( 23823483 ) Serum sulfate level ( 27412988 )	No GWAS studies recorded
Interacting Genes		3 interacting genes: ADORA1 NHERF1 NHERF2	46 interacting genes: ABCC4 ACE2 ACTN4 ACVR2B ADORA2B ADRB2 ATP2B2 BRSK2 CFTR DLGAP4 EZR KCNJ1 LPAR1 LPAR2 P2RY1 PDGFRB PDPK1 PDZK1 PLCB3 PODXL PRKACA PRKCA PTEN PTH1R RDX RPS6KA1 SGK1 SGK3 SIAH1 SLC13A1 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC9A3 SLCO1A2 SLCO3A1 SRY TAFAZZIN TBC1D10A TCF7 TRAF4 UBC WWP2 WWTR1
Entrez ID		5028	9351
HPRD ID		03103	05946
Ensembl ID		ENSG00000169860	ENSG00000065054
Uniprot IDs		P47900	H3BQS0 Q15599
PDB IDs		4XNV 4XNW 7XXH 8WJX	2D11 2HE4 2OCS 4P0C
GO Terms Enriched among Interactors		Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Endomembrane System Protein-membrane Adaptor Activity Phosphatase Binding Localization Within Membrane Positive Regulation Of Nucleoside Transport Negative Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Beta-catenin Binding Renal Phosphate Ion Absorption Renal System Process Negative Regulation Of Mucus Secretion Purine Nucleoside Binding Negative Regulation Of Neurotrophin Production Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Respiratory Gaseous Exchange By Nervous System Process Negative Regulation Of Synaptic Transmission, Glutamatergic Negative Regulation Of Amino Acid Transport G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Regulation Of Respiratory System Process Regulation Of Mucus Secretion Heterotrimeric G-protein Binding Regulation Of Long-term Synaptic Depression Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cellular Localization Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Acute Inflammatory Response Vascular Process In Circulatory System Negative Regulation Of Circadian Sleep/wake Cycle, Sleep Negative Regulation Of Cell Motility Negative Regulation Of Locomotion G Protein-coupled Adenosine Receptor Activity Negative Regulation Of Cell Migration Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Asymmetric Synapse Negative Regulation Of Long-term Synaptic Depression Regulation Of Glomerular Filtration Mucus Secretion Axolemma Regulation Of Metal Ion Transport Circulatory System Process Inorganic Ion Homeostasis Positive Regulation Of Dephosphorylation Negative Regulation Of Glutamate Secretion Regulation Of Monoatomic Ion Transport Negative Regulation Of Synaptic Transmission, GABAergic Negative Regulation Of Circadian Rhythm G Protein-coupled Adenosine Receptor Signaling Pathway	Apical Plasma Membrane PDZ Domain Binding Plasma Membrane Monoatomic Ion Transport Regulation Of Transport Brush Border Membrane Basolateral Plasma Membrane Regulation Of Cell Communication Regulation Of Signaling Sodium Ion Transport Regulation Of Biological Quality Membrane Regulation Of Monoatomic Ion Transport Transmembrane Transport Regulation Of Signal Transduction Positive Regulation Of Transport Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway ATP Binding Regulation Of Intracellular Signal Transduction Chloride Channel Regulator Activity Carnitine Transmembrane Transport Carnitine Transport System Process Protein Serine/threonine/tyrosine Kinase Activity Positive Regulation Of Intracellular Signal Transduction Sodium-independent Organic Anion Transport Sodium-independent Organic Anion Transmembrane Transporter Activity Circulatory System Process Amino-acid Betaine Transport Metal Ion Transport Organic Cation Transport Organic Anion Transport Protein Phosphorylation Quaternary Ammonium Group Transport Xenobiotic Transport Carboxylic Acid Transport Organic Acid Transport Nucleotide Binding Protein Kinase Activity Vascular Process In Circulatory System Phosphorylation Regulation Of MAPK Cascade Positive Regulation Of Cell Communication Positive Regulation Of Signaling Intracellular Chemical Homeostasis Protein Serine/threonine Kinase Activity Intracellular Monoatomic Cation Homeostasis Positive Regulation Of Signal Transduction Intracellular Monoatomic Ion Homeostasis