P2RX4 and WNT4

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		P2RX4	WNT4
Name		purinergic receptor P2X 4	Wnt family member 4
Structure			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Plasma Membrane Membrane Cell Junction Cell Body Perinuclear Region Of Cytoplasm Extracellular Exosome Postsynapse	Extracellular Region Extracellular Space Cytoplasm Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Cell Surface Endocytic Vesicle Membrane Extracellular Matrix Extracellular Exosome
	Molecular Function	Nucleotide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Monoatomic Cation Channel Activity Signaling Receptor Binding Monoatomic Ion Channel Activity Copper Ion Binding Protein Binding ATP Binding Zinc Ion Binding Identical Protein Binding Cadherin Binding Ligand-gated Calcium Channel Activity	Transcription Corepressor Activity Signaling Receptor Binding Frizzled Binding Cytokine Activity Receptor Ligand Activity
	Biological Process	Tissue Homeostasis Regulation Of Sodium Ion Transport Response To Ischemia Monoatomic Ion Transport Response To Stress Signal Transduction Regulation Of Blood Pressure Positive Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Metal Ion Transport Sensory Perception Of Pain Calcium-mediated Signaling Positive Regulation Of Cell Migration Positive Regulation Of Prostaglandin Secretion Response To ATP Monoatomic Ion Transmembrane Transport Response To Fluid Shear Stress Purinergic Nucleotide Receptor Signaling Pathway Endothelial Cell Activation Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Nitric Oxide Biosynthetic Process Behavioral Response To Pain Response To Axon Injury Positive Regulation Of Calcium-mediated Signaling Regulation Of Chemotaxis Sensory Perception Of Touch Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Membrane Depolarization Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Relaxation Of Cardiac Muscle Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To Zinc Ion Cellular Response To ATP Apoptotic Signaling Pathway Monoatomic Cation Transmembrane Transport Regulation Of Ruffle Assembly Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Microglial Cell Migration Positive Regulation Of Endothelial Cell Chemotaxis	Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Mesonephros Development Epithelial To Mesenchymal Transition Embryonic Epithelial Tube Formation Liver Development Gamete Generation Sex Differentiation Fibroblast Growth Factor Receptor Signaling Pathway Male Gonad Development Female Gonad Development Cellular Response To Starvation Negative Regulation Of Gene Expression Negative Regulation Of Steroid Biosynthetic Process Wnt Signaling Pathway Regulation Of Cell-cell Adhesion Cell Differentiation Neuron Differentiation Female Sex Determination Adrenal Gland Development Negative Regulation Of Cell Migration Positive Regulation Of Bone Mineralization Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Collagen Biosynthetic Process T Cell Differentiation In Thymus Immature T Cell Proliferation In Thymus Tube Morphogenesis Non-canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Hormone Metabolic Process Positive Regulation Of MAPK Cascade Cell Fate Commitment Negative Regulation Of Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Meiotic Nuclear Division Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Negative Regulation Of Ras Protein Signal Transduction Oocyte Development Branching Morphogenesis Of An Epithelial Tube Smooth Muscle Cell Differentiation Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Sertoli Cell Differentiation Canonical Wnt Signaling Pathway Somatotropin Secreting Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Mesenchymal To Epithelial Transition Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Kidney Morphogenesis Negative Regulation Of Wound Healing Mammary Gland Epithelium Development Positive Regulation Of Dermatome Development Paramesonephric Duct Development Negative Regulation Of Testicular Blood Vessel Morphogenesis Cellular Response To Transforming Growth Factor Beta Stimulus Nephron Development Renal Vesicle Formation Renal Vesicle Induction Metanephric Mesenchymal Cell Differentiation Mesonephric Tubule Development Metanephric Tubule Formation Metanephric Nephron Development Metanephric Nephron Morphogenesis Apoptotic Signaling Pathway Meiotic Nuclear Division Pericyte Cell Differentiation Negative Regulation Of Male Gonad Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Negative Regulation Of Testosterone Biosynthetic Process Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis Purinergic signaling in leishmaniasis infection	TCF dependent signaling in response to WNT WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Negative regulation of TCF-dependent signaling by WNT ligand antagonists PCP/CE pathway PCP/CE pathway Nephron development
Drugs		Promethazine Eslicarbazepine acetate Eslicarbazepine	None
Diseases		None	46,XX disorders of sex development (Other), including: Mullerian aplasia and hyperandrogenism; McKusick-Kaufman syndrome 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Left ventricular obstructive tract defect (inherited effect) ( 28468790 )	Age-related cognitive decline (language) (slope of z-scores) ( 30954325 ) Appendicular lean mass ( 33097823 ) Birth weight ( 31043758 27680694 ) Bone mineral density (paediatric, lower limb) ( 24945404 ) Bone mineral density (paediatric, skull) ( 24945404 ) Bone mineral density (paediatric, total body less head) ( 28743860 24945404 ) Bone mineral density (paediatric, upper limb) ( 24945404 ) Bone mineral density (total hip) ( 29883787 ) Colorectal cancer ( 25990418 ) Daytime sleep phenotypes ( 27126917 ) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195 ) Dupuytren's disease ( 21732829 28886342 ) Endometriosis ( 20601957 23472165 23104006 28333195 28537267 ) Epithelial ovarian cancer ( 25581431 ) Extremely high intelligence ( 29520040 ) Gestational age at birth (maternal effect) ( 28877031 ) Gynecologic disease ( 31488892 ) Gynecologic disease (multivariate analysis) ( 31488892 ) Heel bone mineral density ( 28869591 30598549 ) Height ( 28552196 ) Hip circumference adjusted for BMI ( 25673412 34021172 ) Hip index ( 34021172 ) Iron status biomarkers (ferritin levels) ( 33536631 ) Lumbar spine bone mineral density ( 22504420 ) Lumbar spine bone mineral density (integral) ( 27476799 ) Lumbar spine bone mineral density (trabecular) ( 27476799 ) Lung function in never smokers (low FEV1 vs high FEV1) ( 26423011 ) Metabolite levels ( 23823483 ) Obesity-related traits ( 23251661 ) Pelvic organ prolapse ( 32184442 ) Right-sided colonic diverticulosis ( 31089239 ) Spine bone size ( 31053729 ) Systolic blood pressure ( 30224653 ) TB-LM or TBLH-BMD (pleiotropy) ( 28743860 ) Thyroid stimulating hormone levels ( 32769997 ) Triglyceride levels ( 34074324 ) Uterine fibroids ( 31649266 31488892 31249589 30194396 ) Uterine fibroids (MTAG) ( 31488892 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		9 interacting genes: CDH5 DNAAF6 KRTAP1-1 KRTAP12-3 KRTAP5-9 MCM2 NBPF19 NOTCH2NLA WNT4	8 interacting genes: APP FZD6 LGALS3BP P2RX4 PORCN SFRP1 SFRP2 TMEM80
Entrez ID		5025	54361
HPRD ID		09017	04601
Ensembl ID		ENSG00000135124	ENSG00000162552
Uniprot IDs		Q99571	P56705
PDB IDs		9BQH 9BQI 9C48	Not available
GO Terms Enriched among Interactors		Intermediate Filament Mitotic DNA Replication Initiation Positive Regulation Of Translational Elongation Nuclear Division Positive Regulation Of Ribosome Biogenesis Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Renal Vesicle Induction Nephron Morphogenesis Positive Regulation Of Aldosterone Biosynthetic Process Positive Regulation Of Glucocorticoid Biosynthetic Process Positive Regulation Of Dermatome Development Negative Regulation Of Male Gonad Development Renal Vesicle Formation Somatotropin Secreting Cell Differentiation Female Sex Determination Paramesonephric Duct Development Positive Regulation Of Cortisol Biosynthetic Process Negative Regulation Of Androgen Biosynthetic Process Metanephric Nephron Morphogenesis Negative Regulation Of Testicular Blood Vessel Morphogenesis Negative Regulation Of Testosterone Biosynthetic Process Metanephric Nephron Development Keratin Filament Positive Regulation Of Establishment Of Endothelial Barrier Protein Localization To Bicellular Tight Junction Positive Regulation Of Cellular Component Biogenesis Regulation Of Ribosome Biogenesis Mitotic Nuclear Division Histone H2A Deubiquitinase Activity Metanephric Tubule Formation Metanephric Mesenchymal Cell Differentiation Thyroid-stimulating Hormone-secreting Cell Differentiation Positive Regulation Of Steroid Hormone Biosynthetic Process Pericyte Cell Differentiation Immature T Cell Proliferation In Thymus Blood Vessel Maturation Fibrinogen Binding Regulation Of Cortisol Biosynthetic Process Mesenchymal Cell Differentiation Involved In Kidney Development Regulation Of Testosterone Biosynthetic Process Histone Binding	Wnt-protein Binding Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Wnt Signaling Pathway Wnt Signaling Pathway Involved In Somitogenesis Regulation Of Midbrain Dopaminergic Neuron Differentiation Non-canonical Wnt Signaling Pathway Development Of Primary Male Sexual Characteristics Regulation Of Canonical Wnt Signaling Pathway Convergent Extension Involved In Axis Elongation Wnt Signaling Pathway Regulation Of Establishment Of Planar Polarity Development Of Primary Sexual Characteristics Neural Tube Closure Regulation Of Wnt Signaling Pathway Cellular Response To X-ray Tube Closure Canonical Wnt Signaling Pathway Regulation Of Dopaminergic Neuron Differentiation Convergent Extension Tube Formation Negative Regulation Of Peptidyl-tyrosine Phosphorylation Digestive Tract Morphogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Response To X-ray Regulation Of Neuron Differentiation Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Cell Projection Organization Positive Regulation Of Nitric Oxide Metabolic Process Neural Tube Development Negative Regulation Of Epithelial To Mesenchymal Transition Somitogenesis Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Segmentation Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Nitric Oxide Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Signal Transduction Regulation Of Nitric Oxide Metabolic Process Negative Regulation Of BMP Signaling Pathway Positive Regulation Of Fat Cell Differentiation Convergent Extension Involved In Somitogenesis