ORM1 and BLVRB

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ORM1	BLVRB
Name		orosomucoid 1	biliverdin reductase B
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Platelet Alpha Granule Lumen Specific Granule Lumen Extracellular Exosome Blood Microparticle Tertiary Granule Lumen	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Biliverdin Reductase [NAD(P)H] Activity Protein Binding Oxidoreductase Activity Transferase Activity Peptidyl-cysteine S-nitrosylase Activity Riboflavin Reductase (NADPH) Activity FMN Reductase (NADPH) Activity FMN Reductase (NADH) Activity
	Biological Process	Regulation Of Immune System Process Acute-phase Response Inflammatory Response Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Tumor Necrosis Factor Production	Insulin Receptor Signaling Pathway Megakaryocyte Differentiation Heme Catabolic Process Negative Regulation Of Insulin Receptor Signaling Pathway
Pathways		Platelet degranulation Neutrophil degranulation	Heme degradation Cytoprotection by HMOX1
Drugs		Amsacrine Lidocaine Progesterone Chlorpromazine Dipyridamole Thalidomide	Riboflavin NADH Biliverdine IX Alpha Flavin mononucleotide Nicotinamide adenine dinucleotide phosphate Lumichrome Mesobiliverdin IV alpha
GWAS		End-stage coagulation ( 23381943 ) Thrombin generation potential phenotypes ( 24357727 ) Tourette syndrome ( 22889924 )	High light scatter reticulocyte count ( 32888494 ) High light scatter reticulocyte percentage of red cells ( 32888494 ) Immature fraction of reticulocytes ( 32888494 ) Otitis media ( 27632927 ) Otitis media (chronic) ( 27632927 ) Otitis media (recurrent) ( 27632927 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 )
Interacting Genes		9 interacting genes: ALB BLVRB CCR5 GLUD1 GSDMB PIK3R3 SERPINE1 TMEM37 TP63	4 interacting genes: ANXA10 HMOX1 ORM1 RPL31
Entrez ID		5004	645
HPRD ID		00724	02967
Ensembl ID		ENSG00000229314	ENSG00000090013
Uniprot IDs		P02763	P30043 V9HWI1
PDB IDs		3KQ0	1HDO 1HE2 1HE3 1HE4 1HE5 5OOG 5OOH 6OPL 7ER6 7ER7 7ER8 7ER9 7ERA 7ERB 7ERC 7ERD 7ERE 8ELL 8ELM 8K4K
GO Terms Enriched among Interactors		Platelet Alpha Granule Lumen Enterobactin Binding Exogenous Protein Binding Cellular Response To Calcium Ion Starvation Biliverdin Reductase [NAD(P)H] Activity Riboflavin Reductase (NADPH) Activity FMN Reductase (NADPH) Activity Insulin Receptor Signaling Pathway FMN Reductase (NADH) Activity Chemokine (C-C Motif) Ligand 5 Binding Glutamate Dehydrogenase (NAD+) Activity Oxidoreductase Activity, Acting On The CH-NH2 Group Of Donors, NAD Or NADP As Acceptor Glutamate Dehydrogenase (NADP+) Activity Glutamate Dehydrogenase [NAD(P)+] Activity Defense Response To Gram-negative Bacterium Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Leukotriene Production Involved In Inflammatory Response Negative Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Somatic Stem Cell Population Maintenance Cloacal Septation Ectoderm And Mesoderm Interaction Epidermal Cell Division Squamous Basal Epithelial Stem Cell Differentiation Involved In Prostate Gland Acinus Development Cytotoxic T Cell Pyroptotic Cell Death Odontogenesis Peptidyl-cysteine S-nitrosylase Activity Negative Regulation Of Integrin-mediated Signaling Pathway Female Genitalia Morphogenesis Negative Regulation Of Mesoderm Development Regulation Of Epidermal Cell Division Regulation Of Smooth Muscle Cell-matrix Adhesion Peptidase Inhibitor Complex Prostatic Bud Formation Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Serine Protease Inhibitor Complex Negative Regulation Of Mitochondrial Depolarization Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Apoptotic Process Cellular Response To Molecule Of Bacterial Origin Cellular Response To Lipopolysaccharide Calcium Ion Transmembrane Transport Negative Regulation Of Macrophage Apoptotic Process L-leucine Binding Glutamate Biosynthetic Process L-glutamate Catabolic Process Positive Regulation Of Odontoblast Differentiation Dentinogenesis Negative Regulation Of Vascular Wound Healing Positive Regulation Of Neuroepithelial Cell Differentiation Negative Regulation Of Plasminogen Activation	Heme Oxidation Smooth Muscle Hyperplasia Heme Oxygenase (decyclizing) Activity Wound Healing Involved In Inflammatory Response Cellular Response To Cisplatin Smooth Muscle Adaptation Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Porphyrin-containing Compound Catabolic Process Negative Regulation Of Cytokine Production Erythrocyte Homeostasis Response To Cisplatin Heme Catabolic Process