NME1 and PID1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		NME1	PID1
Name		NME/NM23 nucleoside diphosphate kinase 1	phosphotyrosine interaction domain containing 1
Structure			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Early Endosome Cytosol Membrane Ruffle Membrane Extracellular Exosome	Cytoplasm
	Molecular Function	Nucleotide Binding Magnesium Ion Binding DNA Binding RNA Binding DNA Endonuclease Activity DNA Nuclease Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Binding ATP Binding 3'-5'-DNA Exonuclease Activity Kinase Activity Transferase Activity Phosphotransferase Activity, Phosphate Group As Acceptor GDP Binding Identical Protein Binding Ribosomal Small Subunit Binding ADP Binding Metal Ion Binding Farnesyl Diphosphate Kinase Activity Coenzyme A Binding Succinyl-CoA Binding Acetyl-CoA Binding	Protein Binding
	Biological Process	GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process DNA Catabolic Process Apoptotic DNA Fragmentation Isoprenoid Metabolic Process Endocytosis Nervous System Development Lactation Negative Regulation Of Cell Population Proliferation Nucleotide Metabolic Process Nucleoside Diphosphate Metabolic Process Nucleoside Triphosphate Biosynthetic Process Cell Differentiation Mammary Gland Development Protein Hexamerization Regulation Of Fatty Acid Biosynthetic Process Regulation Of Apoptotic Process ITP Biosynthetic Process Acetyl-CoA Catabolic Process Positive Regulation Of Epithelial Cell Proliferation	Energy Reserve Metabolic Process Mitochondrion Organization Positive Regulation Of Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of Mitochondrial Fusion Regulation Of Cell Population Proliferation Cellular Response To Leptin Stimulus Fat Cell Differentiation Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of D-glucose Import Negative Regulation Of Insulin Receptor Signaling Pathway Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Fat Cell Proliferation Cellular Response To Cytokine Stimulus Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Fatty Acid Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of ATP Biosynthetic Process Negative Regulation Of ATP Biosynthetic Process Positive Regulation Of ATP Biosynthetic Process
Pathways		Interconversion of nucleotide di- and triphosphates Azathioprine ADME Ribavirin ADME	None
Drugs		Zinc 2'-Deoxyguanosine-5'-Triphosphate Selenocysteine 2',3'-Dehydro-2',3'-Deoxy-Thymidine 5'-Diphosphate Adenosine Phosphonoacetic Acid Stavudine triphosphate Thymidine-5'- Diphosphate 2'-Deoxyguanosine-5'-Diphosphate 2',3'-dideoxy-3'-fluoro-urididine-5'-diphosphate Guanosine-5'-Diphosphate 3'-Deoxy 3'-Amino Adenosine-5'-Diphosphate Zidovudine diphosphate Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form	None
GWAS		Bipolar disorder ( 31043756 ) Conjunctival UV autofluorescence (CUVAF) ( 25590795 ) Metabolite levels ( 23823483 )	Chronic obstructive pulmonary disease ( 28166215 30804561 ) Coronary artery disease ( 33020668 ) FEV1 ( 30804560 ) HDL cholesterol levels ( 32203549 ) Hip circumference adjusted for BMI ( 34021172 ) Lung function (FEV1/FVC) ( 28166213 30804560 ) Medication use (antimigraine preparations) ( 31015401 ) Peak expiratory flow ( 30804560 ) Pulmonary function (smoking interaction) ( 23284291 ) Response to antipsychotic treatment in schizophrenia (reasoning) ( 21107309 ) Total cholesterol levels ( 30498476 ) Triglyceride levels ( 32203549 ) Urinary albumin excretion ( 30220432 ) Urinary albumin excretion (no hypertensive medication) ( 30220432 )
Interacting Genes		35 interacting genes: APEX1 AURKA CCND3 DDX19A FBXO24 FXR1 FXR2 GORASP2 ITGB1 KSR1 LNX1 MIF NIF3L1 NME3 NME4 NTAQ1 NUTF2 NXF1 PID1 POLR1C PRPF6 PRUNE1 RAC1 RORA RORB RRAD SET SMARCD1 SNCA SOX30 SREK1IP1 TERF1 TIAM1 TNPO2 TNPO3	15 interacting genes: ADAMTSL4 BANP CBY2 CCDC33 CPSF7 CRX DNAAF6 GOLGA2 GOPC KRTAP10-1 LRP1 MDFI NME1 NOTCH2NLA THAP1
Entrez ID		4830	55022
HPRD ID		01131	07944
Ensembl ID		ENSG00000239672	ENSG00000153823
Uniprot IDs		A0A384MTW7 P15531	Q7Z2X4
PDB IDs		1JXV 1UCN 2HVD 2HVE 3L7U 4ENO 5UI4 8OOV	Not available
GO Terms Enriched among Interactors		Mitochondrion-mitochondrion Outer Membrane Tether Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Translation At Presynapse, Modulating Synaptic Transmission MRNA Transport RNA Transport Nuclear Import Signal Receptor Activity Regulation Of Long-term Neuronal Synaptic Plasticity Cytoplasmic Stress Granule Cytoplasm Nucleobase-containing Compound Transport Negative Regulation Of Biosynthetic Process Postsynapse Double-stranded Telomeric DNA Binding Cellular Component Assembly UTP Biosynthetic Process GTP Biosynthetic Process UTP Metabolic Process Positive Regulation Of Long-term Neuronal Synaptic Plasticity Nuclear Transport Nucleocytoplasmic Transport Regulation Of Cell Differentiation Central Nervous System Neuron Differentiation Protein Hexamerization Protein Binding Regulation Of Cell Development Regulation Of Macrophage Activation Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Development CTP Biosynthetic Process CTP Metabolic Process Regulation Of Microtubule Polymerization Protein-containing Complex Organization Nucleoside Diphosphate Kinase Activity Regulation Of Hydrogen Peroxide Metabolic Process Nucleus Translation Regulator Activity Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Cytoplasmic Ribonucleoprotein Granule Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Neurotransmitter Uptake Neuron Differentiation Protein-containing Complex Assembly Regulation Of Synaptic Plasticity Nucleosome Disassembly Regulation Of Rho Protein Signal Transduction Regulation Of Neurogenesis GTP Metabolic Process Regulation Of Cell Maturation Protein-DNA Complex Disassembly	Identical Protein Binding