ATP12A and NPY

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ATP12A	NPY
Name		ATPase H+/K+ transporting non-gastric alpha2 subunit	neuropeptide Y
Structure		No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Potassium:proton Exchanging ATPase Complex Actin Cytoskeleton Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cation-transporting ATPase Complex Plasma Membrane Protein Complex	Extracellular Region Extracellular Space Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Terminal Bouton Perikaryon Perinuclear Region Of Cytoplasm GABA-ergic Synapse Neuronal Dense Core Vesicle
	Molecular Function	Nucleotide Binding P-type Sodium:potassium-exchanging Transporter Activity ATP Binding P-type Potassium Transmembrane Transporter Activity P-type Potassium:proton Transporter Activity ATP Hydrolysis Activity Metal Ion Binding	G Protein-coupled Receptor Binding G Protein-coupled Receptor Activity Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Calcium Channel Regulator Activity Protein Binding Neuropeptide Y Receptor Binding
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Sodium Ion Transport Intracellular Sodium Ion Homeostasis Regulation Of PH Establishment Or Maintenance Of Transmembrane Electrochemical Gradient Intracellular Potassium Ion Homeostasis Sodium Ion Export Across Plasma Membrane Potassium Ion Homeostasis Proton Transmembrane Transport Potassium Ion Import Across Plasma Membrane	Response To Yeast Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Neuropeptide Signaling Pathway Chemical Synaptic Transmission Feeding Behavior Regulation Of Blood Pressure Positive Regulation Of Cell Population Proliferation Adult Feeding Behavior Positive Regulation Of Cell-substrate Adhesion Antibacterial Humoral Response Antifungal Humoral Response Central Nervous System Neuron Development Cerebral Cortex Development Neuron Projection Development Positive Regulation Of Appetite Regulation Of Nerve Growth Factor Production Monocyte Activation Innate Immune Response Negative Regulation Of Blood Pressure Positive Regulation Of Dopamine Metabolic Process Short-day Photoperiodism Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Intestinal Epithelial Cell Differentiation Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Synaptic Signaling Via Neuropeptide Positive Regulation Of Eating Behavior Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Synaptic Vesicle Exocytosis
Pathways		Ion transport by P-type ATPases	Peptide ligand-binding receptors G alpha (i) signalling events FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		None	Phentermine 2-aminoisobutyric acid L-tyrosinamide
GWAS		Diastolic blood pressure ( 30224653 ) Meconium ileus in cystic fibrosis ( 30807572 ) Obesity-related traits ( 23251661 )	Adiponectin levels ( 33562295 ) Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Aggressive periodontitis (sex interaction) ( 25256105 ) Body size at age 10 ( 32376654 ) Chronotype ( 30696823 ) Morning person ( 30696823 ) Periodontitis ( 23459936 ) Retinitis pigmentosa ( 33514863 ) Vitamin D levels ( 25208829 )
Interacting Genes		3 interacting genes: GNAI3 NPY PPIB	16 interacting genes: ATP12A BAG6 GHRL MC4R MEP1A MEP1B NPFF NPFFR2 NPY1R NPY2R NPY4R NPY5R NR1H2 PMCH UBQLN1 UBQLN2
Entrez ID		479	4852
HPRD ID		01667	01214
Ensembl ID		ENSG00000075673	ENSG00000122585
Uniprot IDs		B4E0R9 P54707	A4D158 P01303
PDB IDs		Not available	1QFA 1RON 7RTA 7VGX 7X9A 7X9B 7YOO 8K6M 8K6N 8K6O
GO Terms Enriched among Interactors		G Protein-coupled Receptor Binding Negative Regulation Of Adenylate Cyclase Activity Neuropeptide Y Receptor Binding Monocyte Activation Positive Regulation Of Eating Behavior Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Regulation Of Eating Behavior Positive Regulation Of Response To Food Short-day Photoperiodism Regulation Of Nerve Growth Factor Production Positive Regulation Of Dopamine Metabolic Process Antifungal Humoral Response Positive Regulation Of Appetite Synaptic Signaling Via Neuropeptide Intestinal Epithelial Cell Differentiation Adult Feeding Behavior Positive Regulation Of Feeding Behavior Cyclosporin A Binding Endoplasmic Reticulum Chaperone Complex Host-mediated Perturbation Of Viral Genome Replication Host-mediated Activation Of Viral Genome Replication Negative Regulation Of Acute Inflammatory Response Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Response To Yeast Guanyl Nucleotide Binding Regulation Of Response To Food Regulation Of Acute Inflammatory Response To Antigenic Stimulus G-protein Beta/gamma-subunit Complex Binding GTP Metabolic Process Regulation Of Dopamine Metabolic Process Neuronal Dense Core Vesicle Smooth Endoplasmic Reticulum RNA Polymerase Binding Regulation Of Appetite Regulation Of Feeding Behavior Photoperiodism Perinuclear Region Of Cytoplasm Positive Regulation Of Behavior Neuropeptide Hormone Activity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Heterotrimeric G-protein Complex Positive Regulation Of Multicellular Organism Growth G Protein-coupled Receptor Signaling Pathway Regulation Of Response To Nutrient Levels Peptidyl-prolyl Cis-trans Isomerase Activity Host-mediated Activation Of Viral Process Terminal Bouton Positive Regulation Of Nitric Oxide Metabolic Process Calcium Channel Regulator Activity Central Nervous System Neuron Development	Neuropeptide Signaling Pathway Neuropeptide Y Receptor Activity Peptide YY Receptor Activity Pancreatic Polypeptide Receptor Activity Neuropeptide Binding G Protein-coupled Receptor Signaling Pathway Feeding Behavior Negative Regulation Of Transport Positive Regulation Of ERAD Pathway G Protein-coupled Receptor Activity Meprin A Complex Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of ERAD Pathway Regulation Of Feeding Behavior Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Negative Regulation Of Synaptic Transmission Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Response To Endoplasmic Reticulum Stress Positive Regulation Of Circadian Sleep/wake Cycle, Sleep Signaling Negative Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Cell Communication Regulation Of Eating Behavior Outflow Tract Morphogenesis Synaptic Signaling Via Neuropeptide Peptide Hormone Secretion Regulation Of Behavior Peptide Secretion Cardiac Left Ventricle Morphogenesis Positive Regulation Of Digestive System Process Hormone Secretion ERAD Pathway Peptide Transport Regulation Of Response To Food Hormone Transport Regulation Of Secretion By Cell Regulation Of Circadian Sleep/wake Cycle, Sleep Neuropeptide Receptor Activity Positive Regulation Of Circadian Rhythm Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Secretion Regulation Of Circadian Sleep/wake Cycle Negative Regulation Of Cell Communication Negative Regulation Of Signaling Regulation Of Appetite Synaptic Signaling Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Signal Transduction Amide Transport