NEK2 and CSN2

Number of citations: 0 (PubMedID 15147269)
Data Source: BioGRID (enzymatic study)

		NEK2	CSN2
Name		NIMA related kinase 2	casein beta
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Centrosome Cytosol Cytoskeleton Microtubule Plasma Membrane Cilium Microtubule Cytoskeleton Midbody Nuclear Lumen Protein-containing Complex Ciliary Basal Body Intercellular Bridge	Extracellular Region Extracellular Space
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity	Enzyme Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Calcium Ion Binding Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion	Calcium Ion Transport Lactation
Pathways		APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2 GSK3B-mediated proteasomal degradation of PD-L1(CD274)	Nuclear signaling by ERBB4 Developmental Lineage of Mammary Gland Alveolar Cells
Drugs		5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib	None
GWAS		Red cell distribution width ( 27863252 28957414 32888494 ) Serum alkaline phosphatase levels ( 33547301 )	No GWAS studies recorded
Interacting Genes		29 interacting genes: CDC20 CEP250 CHGA CIP2A CSN2 CTNNB1 DCTN1 EDRF1 EIF4A2 FZR1 GIT1 IFT140 IMMT MAD1L1 MAPK1 MCC NDC80 NEK11 PDE4DIP PIN1 PPP1CA PPP1CC PPP1R2 PRKN PTPRD SMURF1 SPTBN4 TCF25 TPM3	18 interacting genes: AURKA CDC42 CDK1 CELA1 CSN3 CSNK2A1 CSNK2B FHL2 GRB2 HTRA2 NEK1 NEK2 NEK9 NFYC PLK1 RAC1 TOLLIP UBQLN2
Entrez ID		4751	1447
HPRD ID		04953	00281
Ensembl ID		ENSG00000117650	ENSG00000135222
Uniprot IDs		F6U4U2 P51955	P05814 W5RWE1
PDB IDs		2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5	Not available
GO Terms Enriched among Interactors		Centrosome Regulation Of Organelle Organization Regulation Of Cell Communication Regulation Of Signal Transduction Regulation Of Signaling Ciliary Basal Body Positive Regulation Of Microtubule Nucleation Regulation Of Cell Cycle Process Regulation Of Cellular Component Organization Ubiquitin Ligase Activator Activity Positive Regulation Of Organelle Organization Intracellular Signal Transduction Organelle Organization Positive Regulation Of Cellular Component Organization Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Checkpoint Regulation Of Microtubule Nucleation Neuron Cellular Homeostasis Regulation Of Centriole-centriole Cohesion Neuronal Cell Body Axon Initial Segment Regulation Of Nuclear Division Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Meiotic Cell Cycle Phase Transition Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Spindle Pole Regulation Of Cell Cycle Acinar Cell Differentiation Synapse Organization Chromosome, Centromeric Region Kinetochore Mitotic Spindle Assembly Checkpoint Signaling Negative Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Microtubule Polymerization Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Hematopoietic Or Lymphoid Organ Development Cell Division Regulation Of Protein Ubiquitination Regulation Of Developmental Growth Trachea Formation PTW/PP1 Phosphatase Complex Negative Regulation Of Mitotic Nuclear Division Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Cytoskeleton Cytosol Regulation Of Circadian Rhythm	Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Phosphorylation Centrosome Centrosome Separation Protein Kinase Activity Protein Phosphorylation Midbody Regulation Of Attachment Of Spindle Microtubules To Kinetochore Kinase Activity Regulation Of Proteasomal Protein Catabolic Process Protein Localization To Site Of Double-strand Break Spindle Midzone Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Cell Division Protein Kinase Binding Regulation Of Cell Cycle Regulation Of Mitotic Nuclear Division Wnt Signaling Pathway Organelle Organization Positive Regulation Of Organelle Organization Microtubule Cytoskeleton Organization Involved In Mitosis Regulation Of Mitotic Cell Cycle Spindle Microtubule Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Mitotic Cell Cycle Regulation Of Nuclear Division Centrosome Cycle Signal Transduction In Response To DNA Damage Nucleotide Binding G2/M Transition Of Mitotic Cell Cycle G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Cell Cycle Cell Cycle G2/M Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Metabolic Process Regulation Of Protein Catabolic Process Regulation Of Proteolysis Cytoskeleton Organization Ventricular Cardiac Muscle Cell Development Thioesterase Binding Regulation Of Cellular Component Organization Mitotic Nuclear Membrane Disassembly Cytoskeleton Cilium Disassembly Positive Regulation Of Protein Catabolic Process Cytosol Regulation Of Cell Cycle Process