SEPTIN2 and STMN1

Number of citations: 0 (PubMedID 21900206)
Data Source: BioGRID (two hybrid)

		SEPTIN2	STMN1
Name		septin 2	stathmin 1
Structure			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Cytoplasm Spindle Cytoskeleton Plasma Membrane Cilium Axoneme Cell Cortex Septin Ring Cell Surface Actin Cytoskeleton Microtubule Cytoskeleton Membrane Midbody Septin Complex Motile Cilium Cell Division Site Cleavage Furrow Photoreceptor Connecting Cilium Ciliary Transition Zone Cell Projection Intercellular Bridge Synapse Ciliary Membrane Extracellular Exosome Sperm Annulus Non-motile Cilium	Cytoplasm Cytosol Cytoskeleton Microtubule Membrane Neuron Projection Extracellular Exosome
	Molecular Function	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Enzyme Regulator Activity Identical Protein Binding Cadherin Binding Molecular Adaptor Activity	Protein Binding Tubulin Binding
	Biological Process	Regulation Of L-glutamate Import Across Plasma Membrane Smoothened Signaling Pathway Spermatogenesis Intracellular Protein Localization Cell Differentiation Regulation Of Protein Localization Cell Division Cilium Assembly Cytoskeleton-dependent Cytokinesis	Mitotic Cytokinesis Microtubule Depolymerization Mitotic Spindle Organization Signal Transduction Nervous System Development Axonogenesis Response To Virus Cell Differentiation Regulation Of Cell Migration Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Negative Regulation Of Rho Protein Signal Transduction Intracellular Signal Transduction Hepatocyte Growth Factor Receptor Signaling Pathway Negative Regulation Of Stress Fiber Assembly Establishment Of Skin Barrier Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Pathways		Anchoring of the basal body to the plasma membrane	Nuclear signaling by ERBB4
GWAS		Liver enzyme levels (alkaline phosphatase) ( 33972514 )	No GWAS studies recorded
Interacting Genes		25 interacting genes: ATP6V0D2 BAZ2B CDC42 CEBPA COG4 CSNK2A1 DAZAP2 DSCAM ESR1 FXR1 JPT2 MTOR PIK3R2 PLEKHF2 RNF31 S100A4 SEPTIN5 SEPTIN6 SEPTIN9 SH3KBP1 SNCA STMN1 STX1A TBC1D21 UBL5	21 interacting genes: CAMK2G CDK1 CDKN1B CEBPA CHEK2 CSNK2A1 ERBB2 FANCC GLP1R HSPA5 HSPA8 HUNK LINC00632 MAPK3 PRKACA PRKCA SEPTIN2 SESTD1 STAT3 UBQLN4 UHMK1
Entrez ID		4735	3925
HPRD ID		03297	01047
Ensembl ID		ENSG00000168385	ENSG00000117632
Uniprot IDs		A0A384N6H6 B5MCX3 Q15019	A0A140VJW2 P16949
PDB IDs		2QA5 2QAG 2QNR 6UPA 6UPQ 6UPR 7M6J	Not available
GO Terms Enriched among Interactors		Cell Division Site Septin Ring Septin Complex Identical Protein Binding Organelle Organization Regulation Of Stress Fiber Assembly Cytoskeleton-dependent Cytokinesis Regulation Of Autophagy Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Regulation Of Protein-containing Complex Assembly Synaptic Vesicle Positive Regulation Of Cell Growth Regulation Of Intracellular Signal Transduction Cell Differentiation Golgi Transport Complex Protein Destabilization Regulation Of Cytoskeleton Organization SNARE Complex Assembly Neuron Projection Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Catabolic Process Molecular Adaptor Activity Intracellular Protein Localization Negative Regulation Of Microtubule Polymerization Regulation Of Cell Communication Regulation Of Signaling Regulation Of Macroautophagy Regulation Of Signal Transduction Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Neurotransmitter Secretion Regulation Of Organelle Organization Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Plasma Membrane Bounded Cell Projection Organization Positive Regulation Of Neurotransmitter Secretion Regulation Of Cell Projection Assembly Regulation Of Cell Projection Organization Positive Regulation Of Growth Regulation Of Actin Filament Organization Cellular Developmental Process Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Cellular Component Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Protein-containing Complex Negative Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Negative Regulation Of Protein-containing Complex Assembly Synaptic Vesicle Exocytosis Positive Regulation Of Protein Targeting To Mitochondrion	Protein Serine Kinase Activity Protein Kinase Activity Protein Serine/threonine Kinase Activity Kinase Activity Phosphorylation Nucleotide Binding ATP Binding Nucleoplasm Protein Phosphorylation Regulation Of Protein Catabolic Process Intracellular Signal Transduction Response To Stress Regulation Of Protein Metabolic Process Cellular Response To Stress Signal Transduction In Response To DNA Damage Regulation Of Cellular Component Organization Phosphate-containing Compound Metabolic Process Regulation Of Cell Cycle Regulation Of Macroautophagy Regulation Of Proteasomal Protein Catabolic Process Regulation Of Autophagy Intracellular Signaling Cassette Regulation Of Transport Regulation Of Protein Localization Transferase Activity Signal Transduction Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Nutrient Levels Intracellular Protein Localization Ubiquitin Protein Ligase Binding Regulation Of Cellular Localization DNA Damage Response Regulation Of Establishment Of Protein Localization Regulation Of Cellular Response To Stress Post-translational Protein Targeting To Membrane, Translocation Intracellular Protein Transport Positive Regulation Of Catabolic Process ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Nucleic Acid Metabolic Process Mitotic Nuclear Membrane Disassembly Cellular Response To Glucagon Stimulus Positive Regulation Of Cell Population Proliferation Regulation Of Proteolysis Response To Hormone Protein Catabolic Process Negative Regulation Of Catabolic Process Interleukin-2-mediated Signaling Pathway