NDN and MIER2

Number of citations: 69 (PubMedID 24722188)
Data Source: BioGRID (two hybrid, two hybrid)

		NDN	MIER2
Name		necdin, MAGE family member	MIER family member 2
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Protein-containing Complex Cell Projection Perikaryon	Nucleus Nucleoplasm Cytoplasm Protein-containing Complex
	Molecular Function	DNA Binding Protein Binding Gamma-tubulin Binding Promoter-specific Chromatin Binding	Transcription Corepressor Activity Histone Deacetylase Activity Protein Binding Histone Deacetylase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neuron Migration Respiratory System Process Regulation Of DNA-templated Transcription Axonogenesis Axonal Fasciculation Central Nervous System Development Respiratory Gaseous Exchange By Respiratory System Glial Cell Migration Post-embryonic Development Sensory Perception Of Pain Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Neurotrophin TRK Receptor Signaling Pathway Neuron Development Axon Extension Multicellular Organismal-level Homeostasis Genomic Imprinting	Negative Regulation Of Transcription By RNA Polymerase II
Pathways		Interleukin-4 and Interleukin-13 signaling	None
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)	None
GWAS		Body size at age 10 ( 32376654 ) Depressive symptoms (SSRI exposure interaction) ( 25649181 ) HDL cholesterol levels ( 32203549 ) Parkinson's disease (age of onset) ( 33884653 ) Plasma anti-thyroid peroxidase levels ( 29678681 ) Serum metabolite concentrations in chronic kidney disease ( 29545352 )	Non-small cell lung cancer ( 23144319 ) Waist circumference adjusted for body mass index ( 28552196 ) Waist-to-hip ratio adjusted for BMI ( 28552196 )
Interacting Genes		47 interacting genes: APBB1IP ARSL BLOC1S6 CALCOCO2 CCDC136 CDR2 DTNBP1 E2F1 E2F4 EEF1AKMT1 EGFR EID1 EPAS1 FAM131C FSD2 FXR2 GKAP1 GOLGA2 HIF1A HNRNPU IFFO1 IL1A IL32 IRS4 LAX1 LPXN MIER2 MKRN2 MYG1 NEFL NGFR NUBP1 NUCB1 NUCB2 P4HA3 PALS2 PJA1 PPARGC1A PPFIA1 SERTAD3 SIRT1 SSX2IP TFIP11 TP53 U2AF1 ZBTB1 ZBTB7B	4 interacting genes: CFTR IL16 MCRS1 NDN
Entrez ID		4692	54531
HPRD ID		03667	11130
Ensembl ID		ENSG00000182636	ENSG00000105556
Uniprot IDs		Q99608 X5D982	Q8N344
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Cis-regulatory Region Sequence-specific DNA Binding Axo-dendritic Transport Circadian Rhythm Transport Along Microtubule Cellular Response To Hypoxia Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Neuron Apoptotic Process Cytoskeleton-dependent Intracellular Transport Axon Cytoplasm Microtubule-based Transport Axonal Transport Circadian Regulation Of Gene Expression Regulation Of Brown Fat Cell Differentiation Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Cellular Response To Insulin Stimulus Cytoplasm Cellular Response To Decreased Oxygen Levels DNA-binding Transcription Activator Activity Promoter-specific Chromatin Binding Embryonic Placenta Development Cellular Homeostasis Regulation Of MiRNA Transcription Positive Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Rhythmic Process Cellular Response To Oxygen Levels Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Intracellular Chemical Homeostasis Organelle Transport Along Microtubule Intracellular Glucose Homeostasis Regulation Of Fibroblast Proliferation Positive Regulation Of Biosynthetic Process Stress-induced Premature Senescence Positive Regulation Of Nucleobase-containing Compound Metabolic Process Protein-containing Complex MRNA Metabolic Process PML Body Anterograde Axonal Transport Nuclear Receptor Binding Connective Tissue Replacement Microtubule-based Process Intracellular Oxygen Homeostasis Regulation Of Attachment Of Mitotic Spindle Microtubules To Kinetochore Positive Regulation Of Gene Expression Protein Domain Specific Binding	Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Neutrophil Activation Perikaryon Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Positive Regulation Of Enamel Mineralization Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Positive Regulation Of Interleukin-1 Alpha Production Poly(G) Binding Telomerase Inhibitor Activity Positive Regulation Of Protein Localization To Nucleolus G-quadruplex RNA Binding Amelogenesis CD4 Receptor Binding ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Neutrophil Activation NSL Complex Regulation Of Protein Localization To Nucleolus Regulation Of Monoatomic Anion Transport Cellular Response To Forskolin Epithelial Fluid Transport Golgi-associated Vesicle Membrane Regulation Of Monoatomic Ion Transport Induction Of Positive Chemotaxis Neurotrophin TRK Receptor Signaling Pathway Ino80 Complex Positive Regulation Of Telomere Maintenance In Response To DNA Damage Positive Regulation Of Protein Localization Regulation Of DNA Strand Elongation Response To Forskolin Chloride Transmembrane Transporter Activity Multicellular Organismal-level Homeostasis Sperm Capacitation Axonal Fasciculation Neuron Projection Fasciculation Genomic Imprinting Poly(U) RNA Binding Water Transport Bicarbonate Transport Positive Regulation Of Positive Chemotaxis Histone Acetyltransferase Complex