NCAM1 and L1CAM

Number of citations: 70 (PubMedID 8509458)
Data Source: HPRD (in vitro)

		NCAM1	L1CAM
Name		neural cell adhesion molecule 1	L1 cell adhesion molecule
Structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Cytosol Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane Extracellular Matrix Neuron Projection Side Of Membrane	Plasma Membrane Focal Adhesion Cell Surface Membrane Axon Dendrite Growth Cone Extracellular Matrix Cell Projection Neuronal Cell Body Axonal Growth Cone
	Molecular Function	Virus Receptor Activity Protein Binding	Protein Binding Axon Guidance Receptor Activity Protein Domain Specific Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell Adhesion Symbiont Entry Into Host Cell Commissural Neuron Axon Guidance Regulation Of Semaphorin-plexin Signaling Pathway	Chemotaxis Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Cell-matrix Adhesion Nervous System Development Axon Guidance Cell Migration Cell Differentiation Neuron Projection Development Positive Regulation Of Axon Extension Synapse Organization Axon Development
Pathways		ECM proteoglycans NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth NCAM1 interactions NCAM1 interactions Signal transduction by L1 RAF/MAP kinase cascade Interferon gamma signaling	Basigin interactions L1CAM interactions L1CAM interactions Recycling pathway of L1 Recycling pathway of L1 Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins Signal transduction by L1
Drugs		None	Ethanol
Diseases		None	Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS) L1 syndrome, including: ; X-linked hydrocephalus; MASA syndrome; X-linked complicated spastic paraplegia type I ; X-linked partial agenesis of corpus callosum Hereditary spastic paraplegia (SPG)
GWAS		Age at first sexual intercourse ( 34211149 27089180 ) Blood protein levels ( 30072576 ) Body mass index ( 25673413 ) Caffeine consumption from coffee ( 33287642 ) Caffeine consumption from coffee or tea ( 33287642 ) Cannabis use ( 27023175 30150663 ) Cardiac muscle measurement ( 21212386 ) Coffee consumption ( 31046077 ) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203 ) Depression ( 33859377 ) Entorhinal cortical thickness ( 21116278 ) Experiencing mood swings ( 29500382 ) Feeling miserable ( 29500382 ) Feeling tense ( 29500382 ) Frailty index ( 34431594 ) Gastroesophageal reflux disease ( 33608531 ) General factor of neuroticism ( 30867560 ) Gut microbiota (bacterial taxa) ( 27694959 ) Haemorrhoidal disease ( 33888516 ) Heel bone mineral density ( 30598549 28869591 ) Irritable bowel syndrome ( 33608531 ) LDL levels x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429 ) Macular thickness ( 30535121 ) Mood instability ( 31168069 ) Neurociticism ( 29500382 ) Number of sexual partners ( 30643258 ) Pulse pressure ( 27841878 ) Risk-taking tendency (4-domain principal component model) ( 30643258 ) Sense of smell ( 26632684 ) Smoking initiation ( 33082346 30617275 ) Smoking initiation (ever regular vs never regular) ( 30679032 ) Smoking status (current vs never) ( 33082346 ) Smoking status (ever vs never smokers) ( 30643258 ) Smoking status (heavy vs never) ( 26423011 ) Suicide attempts in depression or bipolar disorder ( 24964207 ) Systolic blood pressure ( 27841878 ) Total cholesterol levels x SSRI levels interaction in schizophrenia or bipolar disorder ( 33824429 )	No GWAS studies recorded
Interacting Genes		19 interacting genes: ATXN1 BDNF EGFR FGFR1 FYN GDNF GFRA1 L1CAM NCAN PLCG1 PPP1CA PRNP RHEB SPTB ST8SIA2 ST8SIA3 ST8SIA4 TUBB UCHL1	24 interacting genes: ANK1 ANK2 CNTN1 CNTN2 CSNK2A1 EZR FGFR1 ITGA5 ITGAV LINC00839 MSN NCAM1 NCAN NRP1 NRP2 NUMB PEA15 PLXNA1 PLXNB1 PRNP RANBP9 RDX RPS6KA1 RPS6KA2
Entrez ID		4684	3897
HPRD ID		00301	02394
Ensembl ID		ENSG00000149294	ENSG00000198910
Uniprot IDs		A0A087WWD4 H7BYX6 P13591	P32004
PDB IDs		2E3V 2HAZ 2VKW 2VKX 3MTR 5AEA 5LKN	8AFO 8AFP
GO Terms Enriched among Interactors		Alpha-N-acetylneuraminate Alpha-2,8-sialyltransferase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Sialylation Enzyme-linked Receptor Protein Signaling Pathway Ganglioside Biosynthetic Process Regulation Of Synapse Organization Sialyltransferase Activity N-glycan Processing Sialic Acid Binding Ganglioside Metabolic Process Postsynapse Glycosphingolipid Biosynthetic Process Regulation Of Neuron Apoptotic Process System Development Type 5 Metabotropic Glutamate Receptor Binding Regulation Of Apoptotic Process Regulation Of Multicellular Organismal Development Neuron Projection Development Positive Regulation Of Nervous System Development Regulation Of Programmed Cell Death Cell Projection Organization Negative Regulation Of Dendritic Spine Maintenance Developmental Process Plasma Membrane Bounded Cell Projection Organization Nervous System Development Positive Regulation Of Multicellular Organismal Process Regulation Of Extrinsic Apoptotic Signaling Pathway Ceramide Biosynthetic Process Glycosphingolipid Metabolic Process Cell Migration Oligosaccharide Metabolic Process Golgi Apparatus Positive Regulation Of Developmental Process Regulation Of Apoptotic Signaling Pathway Salivary Gland Morphogenesis Glycolipid Biosynthetic Process Dendritic Spine Maintenance Regulation Of Multicellular Organismal Process Neuron Projection Guidance Axon Guidance Regulation Of Nervous System Development Regulation Of Developmental Process Membrane Raft Cell Motility Macromolecule Biosynthetic Process Regulation Of Dendritic Spine Maintenance Regulation Of Glutamate Receptor Signaling Pathway Protein N-linked Glycosylation Adult Locomotory Behavior	Postsynaptic Membrane Semaphorin Receptor Complex Semaphorin Receptor Activity Cell Projection Organization Regulation Of Cellular Component Organization Gonadotrophin-releasing Hormone Neuronal Migration To The Hypothalamus Plasma Membrane Plasma Membrane Bounded Cell Projection Organization Hypothalamus Cell Migration Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Localization To Early Endosome Signal Transduction Semaphorin-plexin Signaling Pathway Neuron Projection Guidance Positive Regulation Of Protein Localization To Endosome Glutamatergic Synapse Cell Adhesion Focal Adhesion Cell Migration Neuron Migration Vestibulocochlear Nerve Structural Organization Dorsal Root Ganglion Morphogenesis Sensory Neuron Axon Guidance Facioacoustic Ganglion Development Regulation Of Early Endosome To Late Endosome Transport Regulation Of Protein Metabolic Process Neuron Projection Development Regulation Of Transport Regulation Of Cell Migration ATPase Binding Regulation Of Cell Motility Ventral Trunk Neural Crest Cell Migration Apical Part Of Cell Cell Motility Regulation Of Cell Communication Regulation Of Locomotion Cell Adhesion Molecule Binding Microvillus Membrane Gland Morphogenesis Cell Periphery Anatomical Structure Formation Involved In Morphogenesis Regulation Of Signal Transduction Intracellular Signal Transduction Dichotomous Subdivision Of Terminal Units Involved In Salivary Gland Branching Sympathetic Neuron Projection Guidance Trigeminal Ganglion Development Axon Guidance Regulation Of Anatomical Structure Morphogenesis Basolateral Plasma Membrane Membrane To Membrane Docking