ATF4 and TRIM24

Number of citations: 41 (PubMedID 20211142)
Data Source: BioGRID (two hybrid)

		ATF4	TRIM24
Name		activating transcription factor 4	tripartite motif containing 24
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Speck Dendrite Membrane Protein-containing Complex Nuclear Periphery Neuron Projection RNA Polymerase II Transcription Regulator Complex Lewy Body Core ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex CHOP-ATF4 Complex	Chromatin Euchromatin Male Germ Cell Nucleus Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasm Mitochondrion Cytosol Nuclear Lumen
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding Identical Protein Binding Leucine Zipper Domain Binding Sequence-specific DNA Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding General Transcription Initiation Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	P53 Binding DNA Binding Chromatin Binding Transcription Coactivator Activity Protein Kinase Activity Ubiquitin-protein Transferase Activity Signaling Receptor Binding Protein Binding Zinc Ion Binding Transferase Activity Nuclear Receptor Binding Estrogen Response Element Binding Sequence-specific DNA Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Histone H3K23ac Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Gamma-aminobutyric Acid Signaling Pathway Circadian Rhythm Response To Toxic Substance Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Neuron Differentiation Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Negative Regulation Of Translational Initiation In Response To Stress Circadian Regulation Of Gene Expression Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To UV Response To Endoplasmic Reticulum Stress Embryonic Hemopoiesis PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Rhythmic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Biomineral Tissue Development Lens Fiber Cell Morphogenesis L-asparagine Metabolic Process Cellular Response To Hypoxia Mitochondrial Respirasome Assembly Negative Regulation Of Cold-induced Thermogenesis Integrated Stress Response Signaling HRI-mediated Signaling GDF15-GFRAL Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Cellular Response To Leucine Starvation Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Sodium-dependent Phosphate Transport	Chromatin Organization Transcription By RNA Polymerase II Positive Regulation Of Gene Expression Protein Ubiquitination Protein Catabolic Process Regulation Of Protein Stability Regulation Of Apoptotic Process Response To Peptide Hormone Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Epithelial Cell Proliferation Negative Regulation Of Epithelial Cell Proliferation Calcium Ion Homeostasis Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Estrogen Stimulus Regulation Of Signal Transduction By P53 Class Mediator
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF4 activates genes in response to endoplasmic reticulum stress PERK regulates gene expression ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulating ER-stress associated genes	Signaling by cytosolic FGFR1 fusion mutants Signaling by FGFR1 in disease Signaling by BRAF and RAF1 fusions
Drugs		Pseudoephedrine	None
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Inflammatory bowel disease ( 23128233 ) Mean corpuscular volume ( 32888494 )	Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644 ) Quantitative traits ( 19197348 )
Interacting Genes		75 interacting genes: AP1M1 APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CEP83 CKAP4 CREB3 CREBBP CREBZF DAPK3 DDIT3 DISC1 DNMT3L EGLN3 EP300 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JDP2 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NAP1L5 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA NLGN3 POLR2C PTCD3 REPS1 RPS6 SAPCD2 SNAP29 SRA1 TARS3 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226	54 interacting genes: AKT1 AR ATF4 BRCA1 BRD7 CBX1 CBX3 CBX5 CREBBP ESR1 ESR2 FOSL1 GTF2E1 H3C1 H3C10 H3C11 H3C12 H3C2 H3C3 H3C4 H3C6 H3C7 H3C8 H4C1 HNF4A HSPA1A HSPB1 MTNR1B NFE2L2 NR2F2 NR3C1 NR3C2 PGR PML RARA RNF141 RNF181 RXRA STAT6 SUMO1 TAF11 TAF1B TAF1C TAF7 THRA TRAF3 TRIM28 TRIM33 TRIM8 UBE2D1 UBE2I UBE2U VDR ZNF10
Entrez ID		468	8805
HPRD ID		06817	04556
Ensembl ID		ENSG00000128272	ENSG00000122779
Uniprot IDs		P18848	O15164
PDB IDs		1CI6	2YYN 3O33 3O34 3O35 3O36 3O37 4YAB 4YAD 4YAT 4YAX 4YBM 4YBS 4YBT 4YC9 4ZQL 5H1T 5H1U 5H1V 7B9X
GO Terms Enriched among Interactors		Integrated Stress Response Signaling RNA Polymerase II Transcription Regulator Complex Intracellular Signaling Cassette Chromatin DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Nucleus Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation Negative Regulation Of RNA Metabolic Process Leukocyte Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Mononuclear Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Protein-DNA Complex Regulation Of Gene Expression Transcription By RNA Polymerase II CAMP Response Element Binding Protein Binding CHOP-C/EBP Complex N-terminal Peptidyl-lysine Acetylation Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Leucine Zipper Domain Binding Chromatin Binding Response To Nutrient Levels	Nucleoplasm Nuclear Receptor Activity Protein-DNA Complex Assembly Regulation Of Gene Expression Macromolecule Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process DNA Binding Gene Expression Protein-containing Complex Epigenetic Regulation Of Gene Expression Intracellular Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Regulation Of Macromolecule Metabolic Process Structural Constituent Of Chromatin Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Chromatin Organization Chromatin Remodeling Nucleus Negative Regulation Of Nucleobase-containing Compound Metabolic Process Hormone-mediated Signaling Pathway Nucleosome Assembly Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Macromolecule Metabolic Process Regulation Of Metabolic Process Nucleosome Protein Heterodimerization Activity Telomere Organization Estrogen Response Element Binding Nucleosome Organization Nuclear Steroid Receptor Activity Regulation Of RNA Metabolic Process Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Chromatin Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific DNA Binding RNA Polymerase II Transcription Regulator Complex MRNA Transcription Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II