ATF4 and GTF2F2

Number of citations: 0 (PubMedID 9295363)
Data Source: BioGRID (pull down), HPRD (in vitro)

		ATF4	GTF2F2
Name		activating transcription factor 4	general transcription factor IIF subunit 2
Structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Mitochondrion Centrosome Cytosol Cytoskeleton Plasma Membrane Membrane Nuclear Speck Dendrite Membrane Protein-containing Complex Nuclear Periphery Neuron Projection RNA Polymerase II Transcription Regulator Complex Lewy Body Core ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex CHOP-ATF4 Complex	Nucleus Nucleoplasm Transcription Factor TFIIF Complex Microtubule Cytoskeleton RNA Polymerase II, Holoenzyme RNA Polymerase II Transcription Regulator Complex
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding Identical Protein Binding Leucine Zipper Domain Binding Sequence-specific DNA Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding General Transcription Initiation Factor Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	DNA Binding Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Intracellular Calcium Ion Homeostasis Gamma-aminobutyric Acid Signaling Pathway Circadian Rhythm Response To Toxic Substance Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Neuron Differentiation Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Negative Regulation Of Translational Initiation In Response To Stress Circadian Regulation Of Gene Expression Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To UV Response To Endoplasmic Reticulum Stress Embryonic Hemopoiesis PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation MRNA Transcription By RNA Polymerase II Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Regulation Of Osteoblast Differentiation Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Rhythmic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Biomineral Tissue Development Lens Fiber Cell Morphogenesis L-asparagine Metabolic Process Cellular Response To Hypoxia Mitochondrial Respirasome Assembly Negative Regulation Of Cold-induced Thermogenesis Integrated Stress Response Signaling HRI-mediated Signaling GDF15-GFRAL Signaling Pathway Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Cellular Response To Leucine Starvation Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Sodium-dependent Phosphate Transport	Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF4 activates genes in response to endoplasmic reticulum stress PERK regulates gene expression ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency NFE2L2 regulating anti-oxidant/detoxification enzymes NFE2L2 regulating ER-stress associated genes	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection HIV Transcription Initiation RNA Polymerase II HIV Promoter Escape Transcription of the HIV genome Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation Viral Messenger RNA Synthesis RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes FGFR2 alternative splicing RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes mRNA Capping mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway Processing of Capped Intron-Containing Pre-mRNA RNA Polymerase II Promoter Escape RNA Polymerase II Transcription Pre-Initiation And Promoter Opening RNA Polymerase II Transcription Initiation RNA Polymerase II Transcription Elongation RNA Polymerase II Transcription Initiation And Promoter Clearance RNA Pol II CTD phosphorylation and interaction with CE Signaling by FGFR2 IIIa TM Estrogen-dependent gene expression
Drugs		Pseudoephedrine	None
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028 ) Inflammatory bowel disease ( 23128233 ) Mean corpuscular volume ( 32888494 )	Normal facial asymmetry (angle of surface orientation score) ( 30631343 ) Type 2 diabetes ( 25760438 )
Interacting Genes		75 interacting genes: AP1M1 APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CEP83 CKAP4 CREB3 CREBBP CREBZF DAPK3 DDIT3 DISC1 DNMT3L EGLN3 EP300 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JDP2 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NAP1L5 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA NLGN3 POLR2C PTCD3 REPS1 RPS6 SAPCD2 SNAP29 SRA1 TARS3 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226	30 interacting genes: AHR AR ARNT ATF2 ATF4 CEBPA CEBPG CREB1 DYNLT2B FHL2 FOS GTF2B GTF2E1 GTF2E2 GTF2F1 HMGA1 HTATSF1 JUN KLF5 MAPRE3 MSX2 POLR2E RPL27A TAF5 TBP TCEA1 TRAM2 URI1 YEATS4 ZMYND19
Entrez ID		468	2963
HPRD ID		06817	01804
Ensembl ID		ENSG00000128272	ENSG00000188342
Uniprot IDs		P18848	P13984
PDB IDs		1CI6	1BBY 1F3U 2BBY 5IY6 5IY7 5IY8 5IY9 5IYA 5IYB 5IYC 5IYD 6O9L 7EDX 7EG7 7EG8 7EG9 7EGA 7EGB 7EGC 7ENA 7ENC 7LBM 7NVR 7NVS 7NVT 7NVU 7NVY 7NVZ 7NW0 7ZWD 7ZX7 7ZX8 8BVW 8BYQ 8BZ1 8GXQ 8GXS 8S51 8S52 8S54 8S55 8S5N 8WAK 8WAL 8WAN 8WAO 8WAP 8WAQ 8WAR 8WAS 8WAT 8WAU 8WAV 8WAW 8WAX 8WAY 8WAZ 8WB0
GO Terms Enriched among Interactors		Integrated Stress Response Signaling RNA Polymerase II Transcription Regulator Complex Intracellular Signaling Cassette Chromatin DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Intracellular Signal Transduction Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Cellular Response To Stress Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Transcription By RNA Polymerase II DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Nucleoplasm Positive Regulation Of Biosynthetic Process Nucleus Sequence-specific Double-stranded DNA Binding DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Positive Regulation Of Macromolecule Metabolic Process Myeloid Cell Differentiation Negative Regulation Of RNA Metabolic Process Leukocyte Differentiation RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of Metabolic Process Mononuclear Cell Differentiation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Protein-DNA Complex Regulation Of Gene Expression Transcription By RNA Polymerase II CAMP Response Element Binding Protein Binding CHOP-C/EBP Complex N-terminal Peptidyl-lysine Acetylation Regulation Of Macromolecule Biosynthetic Process DNA-binding Transcription Factor Binding Leucine Zipper Domain Binding Chromatin Binding Response To Nutrient Levels	DNA-templated Transcription Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Nucleobase-containing Compound Biosynthetic Process Transcription Factor TFIID Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II-specific DNA-binding Transcription Factor Binding Nucleoplasm Positive Regulation Of RNA Metabolic Process RNA Metabolic Process Transcription Regulator Complex Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding RNA Polymerase II General Transcription Initiation Factor Activity Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II MRNA Transcription By RNA Polymerase II Transcription Initiation At RNA Polymerase II Promoter Chromatin Positive Regulation Of Macromolecule Biosynthetic Process Nucleic Acid Metabolic Process Positive Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Cis-regulatory Region Binding MRNA Transcription Promoter-specific Chromatin Binding DNA-templated Transcription Initiation Sequence-specific Double-stranded DNA Binding Integrated Stress Response Signaling Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Factor Activity RNA Polymerase II Core Promoter Sequence-specific DNA Binding Nucleus DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Metabolic Process Regulation Of Gene Expression RNA Polymerase II General Transcription Initiation Factor Binding Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Primary Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of DNA-templated Transcription Initiation