MYL3 and ATG101

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		MYL3	ATG101
Name		myosin light chain 3	autophagy related 101
Structure
GO Annotations	Cellular Component	Cytosol Muscle Myosin Complex Myosin Complex Myosin II Complex Sarcomere A Band I Band	Phagophore Assembly Site Cytoplasm Endoplasmic Reticulum Membrane Cytosol Atg1/ULK1 Kinase Complex
	Molecular Function	Cytoskeletal Motor Activity Actin Monomer Binding Calcium Ion Binding Structural Constituent Of Muscle Myosin II Heavy Chain Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein-containing Complex Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Muscle Contraction Regulation Of Striated Muscle Contraction Skeletal Muscle Tissue Development Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Autophagosome Assembly Autophagy Negative Regulation Of Cell Population Proliferation Positive Regulation Of Autophagy
Pathways		Striated Muscle Contraction	Macroautophagy
Diseases		Hypertrophic cardiomyopathy (HCM)	None
GWAS		Apolipoprotein A1 levels ( 32203549 ) HDL cholesterol levels ( 32203549 ) Metabolite levels ( 23823483 ) Microalbuminuria ( 26631737 31511532 ) Urinary albumin excretion ( 30220432 ) Urinary albumin-to-creatinine ratio ( 31511532 31630189 )	No GWAS studies recorded
Interacting Genes		4 interacting genes: ATG101 CASP3 FTH1 UBC	6 interacting genes: ATG13 ATG4A CSNK2B GABARAP MYL3 PTCH1
Entrez ID		4634	60673
HPRD ID		01183	08566
Ensembl ID		ENSG00000160808	ENSG00000123395
Uniprot IDs		P08590	Q9BSB4
PDB IDs		5TBY 8ACT 8G4L	4WZG 5C50 5XUY 5XV1 5XV3 5XV4 5XV6 8DO8
GO Terms Enriched among Interactors		Negative Regulation Of Cell Population Proliferation Anterior Neural Tube Closure Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Cellular Response To Staurosporine Phospholipase A2 Activator Activity Ferritin Complex Ferroxidase Activity Iron Ion Sequestering Activity Luteolysis Glial Cell Apoptotic Process Positive Regulation Of Pyroptotic Inflammatory Response Response To Anesthetic Regulation Of Synaptic Vesicle Cycle Response To Cobalt Ion Interleukin-18-mediated Signaling Pathway Protein-containing Complex Binding Death-inducing Signaling Complex Regulation Of Cell Population Proliferation Fibroblast Apoptotic Process Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Regulation Of Autophagy Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Activated T Cell Proliferation Regulation Of Ferroptosis Autolysosome Ferric Iron Binding Negative Regulation Of Ferroptosis Protein Tag Activity Atg1/ULK1 Kinase Complex Negative Regulation Of B Cell Proliferation Death Receptor Binding Positive Regulation Of Amyloid-beta Formation Aspartic-type Endopeptidase Activity Axonal Fasciculation Neuron Projection Fasciculation Protein Poly-ADP-ribosylation Catabolic Process Ferrous Iron Binding Platelet Formation Execution Phase Of Apoptosis Positive Regulation Of Amyloid Precursor Protein Catabolic Process Response To X-ray	Mitophagy Autophagy Of Mitochondrion Autophagosome Organization Autophagosome Assembly Protein Kinase Regulator Activity Macroautophagy Piecemeal Microautophagy Of The Nucleus Vacuole Organization Microautophagy Nucleophagy Autophagy Tissue Morphogenesis Neural Plate Axis Specification Autophagosome Epithelial Tube Morphogenesis Myosin II Heavy Chain Binding Response To Chlorate Negative Regulation Of Cell Population Proliferation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Muscle Tissue Development Intracellular Protein Localization Epidermal Cell Fate Specification Smoothened Binding Hedgehog Family Protein Binding Hedgehog Receptor Activity Organelle Assembly Positive Regulation Of Protein K48-linked Ubiquitination Protein-phosphatidylethanolamide Deconjugating Activity Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein Processing Release From Viral Latency Protein Delipidation Positive Regulation Of Activin Receptor Signaling Pathway Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Viral Life Cycle Response To Mitochondrial Depolarisation Regulation Of Protein K48-linked Ubiquitination Adiponectin-activated Signaling Pathway Patched Binding Cell Proliferation Involved In Metanephros Development Mammary Gland Duct Morphogenesis Neural Tube Patterning Dendritic Growth Cone Regulation Of Protein Localization Atg1/ULK1 Kinase Complex Neural Tube Formation Metanephric Collecting Duct Development Cell Proliferation Involved In Kidney Development