MYH7 and KXD1

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		MYH7	KXD1
Name		myosin heavy chain 7	KxDL motif containing 1
Structure			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytoplasm Muscle Myosin Complex Myosin Complex Myosin II Complex Myofibril Sarcomere Z Disc Myosin Filament Supramolecular Fiber	Lysosome Lysosomal Membrane Membrane BLOC-1 Complex Cytoplasmic Side Of Lysosomal Membrane BORC Complex
	Molecular Function	Microfilament Motor Activity Nucleotide Binding Cytoskeletal Motor Activity Actin Binding Protein Binding Calmodulin Binding ATP Binding Actin Filament Binding	Protein Binding
	Biological Process	Regulation Of The Force Of Heart Contraction Regulation Of Heart Rate Skeletal Muscle Contraction Muscle Contraction Striated Muscle Contraction Adult Heart Development Regulation Of The Force Of Skeletal Muscle Contraction Transition Between Fast And Slow Fiber Cardiac Muscle Hypertrophy In Response To Stress Muscle Filament Sliding Regulation Of Slow-twitch Skeletal Muscle Fiber Contraction ATP Metabolic Process Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Vesicle-mediated Transport Lysosome Localization Regulation Of Endosome Size Regulation Of Lysosome Size Organelle Transport Along Microtubule
Drugs		4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID Mavacamten	None
Diseases		Distal muscular dystrophies, including: Welander distal myopathy (WDM); Tibial muscular dystrophy (TMD); Nonaka distal myopathy with rimmed vacuoles (DMRV); Miyoshi myopathy (MM); Laing myopathy (MPD1); Distal nebulin myopathy (DNM); Distal desminopathy (MFM1); alpha-B Crystallinopathy (MFM2); Distal myotilinopathy (MFM3); Distal zaspopathy (MFM4); Distal myopathy 3 (MPD2, VCPDM) Scapuloperoneal myopathy (SPM) Dilated cardiomyopathy (DCM) Myosin storage myopathy (MSM); Hyaline body myopathy Hypertrophic cardiomyopathy (HCM)	None
GWAS		Atrial fibrillation ( 29892015 30061737 ) Resting heart rate ( 20639392 27798624 )	No GWAS studies recorded
Interacting Genes		12 interacting genes: CHRM5 CLVS2 DISC1 KXD1 MYOM2 RND1 RNF167 SNAPIN TEAD1 TEAD3 TEAD4 TULP3	42 interacting genes: APPL1 ARHGDIG C4orf46 CCDC185 CCDC33 CEP170P1 CEP19 CEP63 DYRK2 ELOA ELOA2 EWSR1 EXOC7 FXR2 GABARAPL1 HAUS1 IFT20 ING5 ITSN2 KRT81 LMO3 LNX1 LRRC45 MAB21L3 MAP1LC3A MAP1LC3B MCRS1 MOB1A MYH7 NIF3L1 NUDT18 RABGEF1 RNF183 RPL9 STX11 TCEA2 TPM1 TPM3 UTP6 ZBTB25 ZC4H2 ZNF417
Entrez ID		4625	79036
HPRD ID		01175	14526
Ensembl ID		ENSG00000092054	ENSG00000105700
Uniprot IDs		P12883	Q9BQD3
PDB IDs		2FXM 2FXO 3DTP 4DB1 4P7H 4PA0 4XA1 4XA3 4XA4 4XA6 5CHX 5CJ0 5CJ1 5CJ4 5TBY 5WJ7 5WJB 5WLQ 5WLZ 5WME 6PF2 6PFP 8ACT 8EFD 8EFE 8EFH 8EFI 8ENC 8G4L 8ZB7 8ZI9 9GZ1 9GZ2 9GZ3	Not available
GO Terms Enriched among Interactors		Hippo Signaling Embryonic Organ Development Lysosome Localization Regulation Of Lysosome Size BORC Complex Regulation Of Endosome Size Cytoplasmic Side Of Lysosomal Membrane BLOC-1 Complex Regulation Of Vesicle Size Ciliary Base Transcription Regulator Complex Trophectodermal Cell Fate Commitment Positive Regulation Of Late Endosome To Lysosome Transport Lysosome Organization Neuron Cellular Homeostasis Regulation Of Synaptic Transmission, Glutamatergic Animal Organ Development TEAD-YAP Complex Asymmetric Neuroblast Division Intraciliary Transport Particle A Binding Bronchus Morphogenesis Lysosomal Membrane Organelle Transport Along Microtubule Pyramidal Neuron Migration To Cerebral Cortex Central Region Of Growth Cone	Cellular Response To Nitrogen Starvation Phosphatidylethanolamine Binding Elongin Complex Muscle Thin Filament Tropomyosin Ciliary Basal Body Centrosome Transcription Elongation By RNA Polymerase II Cytoskeleton Protein Binding DNA-templated Transcription Elongation Autophagosome Maturation Autophagosome Membrane Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Mitophagy Muscle Filament Sliding Spindle Pole