MUC2 and GALNT12

Number of citations: 0 (PubMedID 12135769)
Data Source: HPRD (in vitro)

		MUC2	GALNT12
Name		mucin 2, oligomeric mucus/gel-forming	polypeptide N-acetylgalactosaminyltransferase 12
Structure
GO Annotations	Cellular Component	Extracellular Region Golgi Lumen Plasma Membrane Extracellular Matrix Inner Mucus Layer Outer Mucus Layer	Golgi Membrane Golgi Apparatus Membrane
	Molecular Function	Protein Binding Cupric Ion Binding Cuprous Ion Binding	Polypeptide N-acetylgalactosaminyltransferase Activity Protein Binding Transferase Activity Glycosyltransferase Activity Carbohydrate Binding Metal Ion Binding
	Biological Process	Detoxification Of Copper Ion Maintenance Of Gastrointestinal Epithelium Host-mediated Modulation Of Intestinal Microbiota Composition Mucus Secretion	Protein Glycosylation Protein O-linked Glycosylation Protein O-linked Glycosylation Via N-acetyl-galactosamine
Pathways		Defective GALNT3 causes HFTC Defective C1GALT1C1 causes TNPS Defective GALNT12 causes CRCS1 Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Defective GALNT12 causes CRCS1 O-linked glycosylation of mucins
Drugs		Pranlukast Colforsin	None
GWAS		Asthma ( 30929738 31361310 31959851 32296059 34103634 ) Asthma (adult onset) ( 30929738 ) Interstitial lung disease ( 23583980 ) Medication use (adrenergics, inhalants) ( 31015401 )	Asthma ( 31959851 ) Autism spectrum disorder ( 34069769 ) Brain morphology (MOSTest) ( 32665545 ) FEV1 ( 30804560 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) joint destruction in rheumatoid arthritis (rapid vs slow) ( 33585033 ) Left–right brain asymmetry ( 33723403 ) Lung function (FEV1/FVC) ( 30804560 ) Peak expiratory flow ( 30804560 ) Serum galactose-deficient IgA1 levels in IgA nephropathy ( 33593824 )
Interacting Genes		4 interacting genes: GALNT12 GALNT14 MLH1 PLEKHM1	16 interacting genes: APP BMPR1A BUB1 CDH1 CDKN2A FBXW7 MLH3 MSH2 MUC1 MUC2 MUC5AC MUC7 PIK3CA PMS2 RB1 SRC
Entrez ID		4583	79695
HPRD ID		11828	13561
Ensembl ID		ENSG00000198788	ENSG00000119514
Uniprot IDs		A0A3S8TMF2 Q02817	Q8IXK2
PDB IDs		6RBF 6TM2 6TM6 7A5O 7POV 7PP6 7PRL 7QCL 7QCN 7QCU 8CK2 8S03	6PXU
GO Terms Enriched among Interactors		Telomere Localization Polypeptide N-acetylgalactosaminyltransferase Activity Protein O-linked Glycosylation Via N-acetyl-galactosamine Organelle Localization Chromosome Localization Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Telomere Tethering At Nuclear Periphery Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Chiasma Post-transcriptional Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Protein O-linked Glycosylation Protein Glycosylation Glycosylation Macromolecule Glycosylation Guanine/thymine Mispair Binding Negative Regulation Of Mitotic Recombination Nuclear Pore Cytoplasmic Filaments Carbohydrate Binding Glycosyltransferase Activity Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Glycoprotein Biosynthetic Process Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination Transcription-dependent Tethering Of RNA Polymerase II Gene DNA At Nuclear Periphery Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Autolysosome Membrane Glycoprotein Metabolic Process Nuclear Pore Outer Ring Nuclear Pore Complex Assembly Somatic Hypermutation Of Immunoglobulin Genes Meiotic Chromosome Segregation Spindle Midzone Assembly Chromosome Organization Somatic Diversification Of Immune Receptors Via Somatic Mutation Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Nuclear Pore Nuclear Basket Nuclear Inclusion Body Nuclear Pore Organization Positive Regulation Of Ruffle Assembly Autolysosome Autophagosome-lysosome Fusion	Golgi Lumen Mismatched DNA Binding Regulation Of Mitotic Cell Cycle ATP-dependent DNA Damage Sensor Activity Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Regulation Of Cell Cycle Phase Transition Mismatch Repair Negative Regulation Of Cell Development Homeostatic Process Regulation Of Growth Regulation Of Developmental Process Regulation Of Protein Localization To Nucleus Chromosome Organization Positive Regulation Of Isotype Switching To IgA Isotypes Centromeric DNA Binding Mismatch Repair Complex Negative Regulation Of Cell Cycle Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Signaling Receptor Activator Activity Regulation Of Cell Cycle Regulation Of Cell Cycle G1/S Phase Transition Positive Regulation Of Biosynthetic Process Regulation Of Immune System Process Regulation Of Cell Cycle Process Cellular Response To Stress Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Protein Localization Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Isotype Switching To IgG Isotypes Negative Regulation Of Cell Cycle Phase Transition Somatic Hypermutation Of Immunoglobulin Genes Regulation Of Multicellular Organismal Process Regulation Of Neuron Apoptotic Process Somatic Diversification Of Immune Receptors Via Somatic Mutation Intracellular Signal Transduction Regulation Of Isotype Switching To IgG Isotypes Cellular Response To Oxygen-containing Compound Positive Regulation Of Developmental Process Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Cell Cycle Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Protein Localization Response To Stress ATP Binding Negative Regulation Of Anoikis Negative Regulation Of Macromolecule Metabolic Process