MT1F and NOP2

Number of citations: 56 (PubMedID 25416956)
Data Source: BioGRID (two hybrid)

		MT1F	NOP2
Name		metallothionein 1F	NOP2 nucleolar protein
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Protein Binding Zinc Ion Binding Metal Ion Binding	RNA Binding Protein Binding Methyltransferase Activity RNA Methyltransferase Activity S-adenosylmethionine-dependent Methyltransferase Activity RRNA (cytosine-C5-)-methyltransferase Activity Transferase Activity
	Biological Process	Intracellular Zinc Ion Homeostasis Detoxification Of Copper Ion Negative Regulation Of Growth Cellular Response To Cadmium Ion Cellular Response To Copper Ion Cellular Response To Zinc Ion	Ribosomal Large Subunit Assembly Maturation Of LSU-rRNA RNA Methylation RRNA Processing RNA Processing Positive Regulation Of Cell Population Proliferation Methylation Ribosome Biogenesis Ribosomal Large Subunit Biogenesis RRNA Base Methylation Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Metallothioneins bind metals	rRNA modification in the nucleus and cytosol TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation
Drugs		Silver	None
GWAS		Gambling ( 22780124 ) Height ( 18391951 )	No GWAS studies recorded
Interacting Genes		2 interacting genes: NOP2 SHBG	16 interacting genes: CDC42 CDCA7L CEBPA CEP70 KPNA6 MCRS1 MT1F NPM1 PTPRJ PVT1 RAB2B RNF10 SUMO2 UBE2I USP7 VPS52
Entrez ID		4494	4839
HPRD ID		01127	01244
Ensembl ID		ENSG00000198417	ENSG00000111641
Uniprot IDs		H3BRY8 P04733	P46087
PDB IDs		Not available	8FKT 8FKU 8FKV 8FKW 8FKX 8FKY
GO Terms Enriched among Interactors		RRNA (cytosine-C5-)-methyltransferase Activity Androgen Binding RRNA Base Methylation RNA Methyltransferase Activity Maturation Of LSU-rRNA S-adenosylmethionine-dependent Methyltransferase Activity Ribosomal Large Subunit Assembly RRNA Methylation Steroid Binding RRNA Modification Ribosomal Large Subunit Biogenesis RNA Methylation	Macrophage Differentiation Positive Regulation Of Protein Localization To Nucleolus Regulation Of Protein Localization To Nucleolus Myeloid Cell Differentiation SUMO Transferase Activity PML Body Leukocyte Differentiation Mononuclear Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nuclear Body Presynaptic Cytosol Postsynaptic Cytosol Regulation Of DNA-templated Transcription Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of RNA Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Gene Expression Positive Regulation Of Transcription By RNA Polymerase II Regulation Of MRNA Stability Involved In Cellular Response To UV Regulation Of EIF2 Alpha Phosphorylation By DsRNA Embryonic Ectodermal Digestive Tract Development SUMO Conjugating Enzyme Activity Positive Regulation Of Macromolecule Biosynthetic Process Protein Sumoylation Glutamatergic Synapse Postsynapse Regulation Of Vesicle-mediated Transport Nucleolus Positive Regulation Of Biosynthetic Process Positive Regulation Of Metabolic Process Regulation Of RNA Metabolic Process Nuclear Transport Nucleocytoplasmic Transport GBD Domain Binding Storage Vacuole Response To Vitamin B2 C/EBP Complex Regulation Of Endoribonuclease Activity Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Regulation Of Growth Negative Regulation Of Protein Kinase Activity