MSR1 and HSPA1A

Number of citations: 0 (PubMedID 11785981)
Data Source: HPRD (in vivo, in vitro)

		MSR1	HSPA1A
Name		macrophage scavenger receptor 1	heat shock protein family A (Hsp70) member 1A
Structure
GO Annotations	Cellular Component	Collagen Trimer Plasma Membrane Membrane Endocytic Vesicle Membrane Low-density Lipoprotein Particle	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Centriole Cytosol Cytoskeleton Plasma Membrane Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Vesicle Protein-containing Complex Perinuclear Region Of Cytoplasm Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen Ribonucleoprotein Complex
	Molecular Function	Amyloid-beta Binding Scavenger Receptor Activity Protein Binding Low-density Lipoprotein Particle Binding Cargo Receptor Activity	Nucleotide Binding Virus Receptor Activity G Protein-coupled Receptor Binding Transcription Corepressor Activity RNA Binding Signaling Receptor Binding Protein Binding ATP Binding ATP Hydrolysis Activity Enzyme Binding Heat Shock Protein Binding Denatured Protein Binding Ubiquitin Protein Ligase Binding Death Receptor Agonist Activity Histone Deacetylase Binding Protein Folding Chaperone Cadherin Binding Receptor Ligand Activity Unfolded Protein Binding Misfolded Protein Binding C3HC4-type RING Finger Domain Binding Disordered Domain Specific Binding Transcription Regulator Inhibitor Activity ATP-dependent Protein Disaggregase Activity ATP-dependent Protein Folding Chaperone
	Biological Process	Endocytosis Receptor-mediated Endocytosis Phagocytosis, Engulfment Negative Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Cholesterol Transport Plasma Lipoprotein Particle Clearance Lipoprotein Transport Establishment Of Localization In Cell Amyloid-beta Clearance	Negative Regulation Of Transcription By RNA Polymerase II MRNA Catabolic Process Protein Folding Response To Unfolded Protein Lysosomal Transport Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Regulation Of Protein Ubiquitination Negative Regulation Of Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Interleukin-8 Production Positive Regulation Of RNA Splicing Cellular Response To Oxidative Stress Cellular Response To Heat Cellular Response To Unfolded Protein Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation ATP Metabolic Process Symbiont Entry Into Host Cell Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Cellular Heat Acclimation Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Steroid Hormone Stimulus Positive Regulation Of Microtubule Nucleation Negative Regulation Of Inclusion Body Assembly Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitotic Spindle Assembly Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Scavenging by Class A Receptors Scavenging by Class A Receptors	Viral RNP Complexes in the Host Cell Nucleus Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation AUF1 (hnRNP D0) binds and destabilizes mRNA Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt) Regulation of HSF1-mediated heat shock response HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand Attenuation phase HSF1-dependent transactivation Neutrophil degranulation PKR-mediated signaling Mitochondrial unfolded protein response (UPRmt)
GWAS		Alcohol dependence ( 26365420 ) Blood protein levels ( 23696881 ) HDL cholesterol levels in HIV infection ( 33109212 ) Hip circumference adjusted for BMI ( 28552196 ) Neurological blood protein biomarker levels ( 31320639 ) Triglyceride levels ( 32203549 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )	Asthma ( 31619474 ) Asthma (childhood onset) ( 31619474 ) Asthma and major depressive disorder ( 31619474 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Inflammatory bowel disease ( 28067908 ) Schizophrenia ( 30285260 ) Systemic lupus erythematosus ( 32771030 ) Ulcerative colitis ( 28067908 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 34021172 )
Interacting Genes		9 interacting genes: ADRB2 ATP6V0C FA2H HSPA1A LEPROTL1 MALL NKG7 SEC22A SNCA	95 interacting genes: ACE2 AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAAF4 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJB4 DNAJC3 EGFR EIF2AK2 EIF4ENIF1 ERBB2 ERBB3 FANCC FILNC1 FNDC3B FOS FTCD GPR37 GRIN1 GRIN2D HAP1 HCFC1 HEMGN HIVEP1 HMGA1 HSBP1 HSF1 HSPA8 HSPBP1 IKBKG INS KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 OGT PEX5 PGR PLG POT1 PPP1R15A PRKCA PSMC5 PTGES3 PTMA PTPRF RAP1A RAPGEF2 RHOA SAE1 SLC13A1 SLC5A1 SNCB SNRK SOX9 ST13 STIP1 STUB1 SUMO2 TCERG1 TGM2 TOMM70 TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 UBE2D3 XIAP YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		4481	3303
HPRD ID		01092	00774
Ensembl ID		ENSG00000038945	ENSG00000204389
Uniprot IDs		B4DDJ5 P21757	A8K5I0 B3KTT5 P0DMV8 P0DMV9
PDB IDs		7DPX	1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 3Q49 4IO8 4J8F 4PO2 4WV5 4WV7 5AQW 5AQX 5AQY 5AQZ 5AR0 5BN8 5BN9 5BPL 5BPM 5BPN 5GJJ 5MKR 5MKS 5XI9 5XIR 6FDT 6FHK 6G3R 6G3S 6JPV 6K39 6ZYI 7F4X 7F4Z 7F50 7FGM 7GY4 7GY5 7GY6 7GY7 7GY8 7GY9 7GYA 7GYB 7GYC 7GYD 7GYE 7GYF 7GYG 7GYH 7GYI 7GYJ 7GYK 7GYL 7GYM 7GYN 7GYO 7GYP 7GYQ 7GYR 7GYS 7GYT 7GYU 7GYV 7GYW 7GYX 7KW7 7Q4R
GO Terms Enriched among Interactors		Establishment Of Localization In Cell Inclusion Body Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Norepinephrine-epinephrine Vesicle-mediated Transport Vacuolar Transport Positive Regulation Of Mini Excitatory Postsynaptic Potential Regulation Of Microtubule Polymerization Membrane Organization Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Fatty Acid 2-hydroxylase Activity Enzyme Binding Regulation Of Autophagy Beta2-adrenergic Receptor Activity Denatured Protein Binding Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Sebaceous Gland Cell Differentiation Glucosylceramide Biosynthetic Process Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Beta-adrenergic Receptor Activity Mitochondrial Membrane Organization Regulation Of Microtubule Polymerization Or Depolymerization Positive Regulation Of Defense Response Regulated Exocytosis Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Central Nervous System Myelin Maintenance Lysosome Norepinephrine Binding Lysosomal Transport Positive Regulation Of Organelle Organization Intracellular Transport Synaptic Vesicle Membrane Death Receptor Agonist Activity Cytolytic Granule Membrane Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake Response To Psychosocial Stress	Regulation Of Programmed Cell Death Protein-folding Chaperone Binding Protein Folding Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Cytosol Positive Regulation Of Macromolecule Metabolic Process Protein Folding Chaperone Complex Negative Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Apoptotic Process Cytoplasm Intracellular Signal Transduction Heat Shock Protein Binding Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Positive Regulation Of Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Protein-containing Complex Intracellular Signaling Cassette Ubiquitin Protein Ligase Binding Response To Stress Regulation Of Protein Metabolic Process Hsp70 Protein Binding Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Adenyl-nucleotide Exchange Factor Activity Apoptotic Process Positive Regulation Of Protein Metabolic Process Regulation Of Protein Stability Response To Heat Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Programmed Cell Death Negative Regulation Of RNA Metabolic Process Cell Death Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Oxygen-containing Compound Regulation Of Signal Transduction Negative Regulation Of DNA-templated Transcription Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Biosynthetic Process Response To Temperature Stimulus Neuron Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Intracellular Signal Transduction