MPP3 and IDUA

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		MPP3	IDUA
Name		MAGUK p55 scaffold protein 3	alpha-L-iduronidase
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Apical Plasma Membrane Anchoring Junction	Lysosome Lysosomal Lumen Extracellular Exosome
	Molecular Function	Protein Binding PDZ Domain Binding	L-iduronidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Signaling Receptor Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds
	Biological Process	None	Carbohydrate Metabolic Process Disaccharide Metabolic Process Glycosaminoglycan Catabolic Process Heparan Sulfate Proteoglycan Catabolic Process Dermatan Sulfate Proteoglycan Catabolic Process Heparin Proteoglycan Catabolic Process
Pathways		None	HS-GAG degradation CS/DS degradation MPS I - Hurler syndrome (HS-GAG degradation) MPS I - Hurler syndrome (CS/DS degradation)
Diseases		None	Mucopolysaccharidosis type I (MPS1); Hurler-Scheie syndrome (MPS1HS); Hurler syndrome (MPS1H); Scheie syndrome (MPS1S)
GWAS		HDL cholesterol levels ( 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 24097068 )	A body shape index ( 34021172 ) Blood protein levels ( 30072576 ) Heel bone mineral density ( 30598549 ) Limited cutaneous systemic scleroderma ( 29293537 ) Lumbar spine bone mineral density ( 22504420 ) Mean reticulocyte volume ( 32888494 ) Polymyositis ( 26362759 ) Primary biliary cholangitis ( 26394269 )
Interacting Genes		37 interacting genes: APP ARL2BP BTBD1 CADM1 CCDC137 CRABP1 ERBIN EZR FAM171B FBXO7 GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PKNOX1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZNF655 ZPR1	1 interacting genes: MPP3
Entrez ID		4356	3425
HPRD ID		03069	02016
Ensembl ID		ENSG00000161647	ENSG00000127415
Uniprot IDs		D3DX46 Q13368	P35475
PDB IDs		Not available	3W81 3W82 4KGJ 4KGL 4KH2 4MJ2 4MJ4 4OBR 4OBS 6I6R 6I6X
GO Terms Enriched among Interactors		None	Fibroblast Growth Factor Receptor Apoptotic Signaling Pathway Positive Regulation Of Phospholipase Activity Bone Maturation Fibroblast Growth Factor Receptor Activity Endochondral Bone Growth Positive Regulation Of Lipase Activity Chondrocyte Proliferation Bone Growth Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Fibroblast Growth Factor Binding Regulation Of Tyrosine Phosphorylation Of STAT Protein Endochondral Ossification Bone Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Chondrocyte Differentiation Transmembrane Receptor Protein Tyrosine Kinase Activity Organ Growth Bone Mineralization Fibroblast Growth Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via JAK-STAT