MPP3 and PLK2

Number of citations: 0 (PubMedID 16169070)
Data Source: BioGRID (two hybrid), HPRD (two hybrid)

		MPP3	PLK2
Name		MAGUK p55 scaffold protein 3	polo like kinase 2
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Adherens Junction Membrane Apical Plasma Membrane Anchoring Junction	Kinetochore Chromatin Spindle Pole Nucleus Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Dendrite Cell Projection
	Molecular Function	Protein Binding PDZ Domain Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity ATP-dependent Protein Binding Protein Serine Kinase Activity
	Biological Process	None	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Negative Regulation Of Inflammatory Response To Antigenic Stimulus Protein Phosphorylation Mitotic Spindle Organization Ras Protein Signal Transduction Memory Positive Regulation Of Autophagy Regulation Of Cell Cycle Process Negative Regulation Of Angiogenesis DNA Damage Response, Signal Transduction By P53 Class Mediator Rap Protein Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Protein Catabolic Process Regulation Of Centriole Replication Regulation Of Synaptic Plasticity Long-term Synaptic Potentiation Long-term Synaptic Depression Negative Regulation Of Apoptotic Process In Bone Marrow Cell Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of Cellular Senescence
Pathways		None	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain CD163 mediating an anti-inflammatory response NPAS4 regulates expression of target genes
Drugs		None	Fostamatinib
GWAS		HDL cholesterol levels ( 30698716 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 24097068 )	Blond vs. brown/black hair color ( 30531825 ) Diastolic blood pressure ( 30224653 ) Esophageal adenocarcinoma x smoking interaction ( 29551738 ) Multisite chronic pain ( 33830993 ) Triglyceride levels ( 32203549 ) Type 2 diabetes (age of onset) ( 28060188 ) Working memory ( 31598132 )
Interacting Genes		37 interacting genes: APP ARL2BP BTBD1 CADM1 CCDC137 CRABP1 ERBIN EZR FAM171B FBXO7 GNG7 HAP1 HSH2D IDUA INSM1 KBTBD4 KRTAP10-3 L3MBTL2 LIN7A MCM2 MDH1 NOA1 PKNOX1 PLK2 RAB31 RPS2 RRAGC SCN2A SF3B3 SNTG2 SRPK2 TIRAP TMEM37 TRAF2 TRIM41 ZNF655 ZPR1	16 interacting genes: AP1B1 AP1G1 AP2A1 APP CASK CDC20B CENPU CIB1 DNM1 MPP3 NEDD4 NRIP1 NSF TSC1 TSC2 TUBA1A
Entrez ID		4356	10769
HPRD ID		03069	06118
Ensembl ID		ENSG00000161647	ENSG00000145632
Uniprot IDs		D3DX46 Q13368	A0A087WUH9 Q9NYY3
PDB IDs		Not available	4I5M 4I5P 4I6B 4I6F 4I6H 4RS6 4XB0
GO Terms Enriched among Interactors		None	Clathrin-coated Pit Intracellular Protein Transport Endocytosis Membrane Coat Establishment Of Localization In Cell TSC1-TSC2 Complex Vesicle-mediated Transport Intracellular Transport Regulation Of Vesicle-mediated Transport Basolateral Protein Secretion Import Into Cell Lysosomal Membrane Cellular Localization Protein Transport Perinuclear Region Of Cytoplasm Positive Regulation Of Protein Catabolic Process Clathrin Adaptor Complex AP-1 Adaptor Complex Adult Locomotory Behavior Positive Regulation Of Protein Metabolic Process Intracellular Protein Localization Synapse Organization Establishment Of Protein Localization Associative Learning Golgi Apparatus Filopodium Tip Clathrin Adaptor Activity Post-Golgi Vesicle-mediated Transport Melanosome Assembly Synapse Positive Regulation Of Catabolic Process Trans-Golgi Network Membrane Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Cell-matrix Adhesion Platelet Dense Granule Organization Low-density Lipoprotein Particle Receptor Binding Recycling Endosome Regulation Of Transport Regulation Of Protein Catabolic Process Adult Behavior Ionotropic Glutamate Receptor Binding Negative Regulation Of Cell Population Proliferation Learning Cytosol Vesicle Budding From Membrane Clathrin-coated Vesicle Membrane Receptor-mediated Endocytosis Melanosome Organization Negative Regulation Of Macroautophagy Pigment Granule Organization