MMP3 and SPOCK3

Number of citations: 0 (PubMedID 11751414)
Data Source: HPRD (in vivo)

		MMP3	SPOCK3
Name		matrix metallopeptidase 3	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 3
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Cytosol Extracellular Matrix	Extracellular Region Extracellular Space Extracellular Matrix
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Metal Ion Binding	Enzyme Inhibitor Activity Calcium Ion Binding Collagen Binding Glycosaminoglycan Binding Metalloendopeptidase Inhibitor Activity Peptidase Inhibitor Activity Extracellular Matrix Binding
	Biological Process	Immune System Process Proteolysis Extracellular Matrix Disassembly Protein Catabolic Process Extracellular Matrix Organization Regulation Of Cell Migration Collagen Catabolic Process Positive Regulation Of Protein-containing Complex Assembly Cellular Response To Reactive Oxygen Species Innate Immune Response Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To UV-A Cellular Response To Nitric Oxide Regulation Of Neuroinflammatory Response Response To Amyloid-beta Negative Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Motility
Pathways		Collagen degradation Collagen degradation Degradation of the extracellular matrix Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Assembly of collagen fibrils and other multimeric structures EGFR Transactivation by Gastrin EGFR Transactivation by Gastrin Interleukin-4 and Interleukin-13 signaling Extra-nuclear estrogen signaling	Activation of Matrix Metalloproteinases
Drugs		Marimastat N-Hydroxy 1n(4-Methoxyphenyl)Sulfonyl-4-(Z,E-N-Methoxyimino)Pyrrolidine-2r-Carboxamide 3-Methylpyridine A Disubstituted Succinyl Caprolactam Hydroxymate Mmp3inhibitor N-Hydroxy-4-[(4-Methoxylphenyl)Sulfonyl]-2,2-Dimethyl-Hexahydro-1,4-Thiazepine-3(S)-Carboxamide (1n)-4-N-Butoxyphenylsulfonyl-(2r)-N-Hydroxycarboxamido-(4s)-Methanesulfonylamino-Pyrrolidine 3-(1h-Indol-3-Yl)-2-[4-(4-Phenyl-Piperidin-1-Yl)-Benzenesulfonylamino]-Propionic Acid Hydroxyaminovaline 4-methoxybenzenesulfinate 5-Methyl-5-(4-Phenoxy-Phenyl)-Pyrimidine-2,4,6-Trione 1-Benzyl-3-(4-Methoxy-Benzenesulfonyl)-6-Oxo-Hexahydro-Pyrimidine-4-Carboxylic Acid Hydroxyamide N-Hydroxy-1-(4-Methoxyphenyl)Sulfonyl-4-Benzyloxycarbonyl-Piperazine-2-Carboxamide R-2-{[4'-Methoxy-(1,1'-Biphenyl)-4-Yl]-Sulfonyl}-Amino-6-Methoxy-Hex-4-Ynoic Acid 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2-yl)-ureido]-N-methyl-3-phenyl-propionamide [4-(4-PHENYL-PIPERIDIN-1-YL)-BENZENESULFONYLAMINO]-ACETIC ACID [2-(5-Mercapto-[1,3,4]thiadiazol-2-ylcarbamoyl)-1-phenyl-ethyl]-carbamic acid benzyl ester 2-[3-(5-Mercapto-[1,3,4]thiadiazol-2yl)-ureido]-N-methyl-3-pentafluorophenyl-propionamide N~2~-(biphenyl-4-ylsulfonyl)-N-hydroxy-N~2~-(2-hydroxyethyl)glycinamide 3-[(4'-cyanobiphenyl-4-yl)oxy]-N-hydroxypropanamide N-ISOBUTYL-N-[4-METHOXYPHENYLSULFONYL]GLYCYL HYDROXAMIC ACID N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID 2-(2-{2-[(BIPHENYL-4-YLMETHYL)-AMINO]-3-MERCAPTO-PENTANOYLAMINO}-ACETYLAMINO)-3-METHYL-BUTYRIC ACID METHYL ESTER	None
GWAS		Alzheimer's disease ( 22832961 ) Blood protein levels ( 30072576 ) Blood protein levels in cardiovascular risk ( 28369058 ) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798 ) Peripheral artery disease ( 31285632 ) Post bronchodilator FEV1/FVC ratio ( 26634245 ) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245 )	Blood protein levels ( 30072576 ) Cognitive function ( 28808816 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Immune reponse to smallpox (secreted IL-10) ( 22610502 ) Medial orbital frontal cortex volume ( 31530798 ) Obesity-related traits ( 23251661 ) Total antioxidant status in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683 ) Verbal declarative memory ( 25648963 ) Weight ( 28552196 )
Interacting Genes		19 interacting genes: ACAN BCAN CCL13 CCL2 CCL7 CCL8 DCN HAPLN1 IGFBP3 MEOX2 MMP14 PLG SERPINE1 SPOCK1 SPOCK3 SPP1 TIMP1 TIMP3 TNFSF11	4 interacting genes: CREB3 MMP14 MMP3 SPOCK2
Entrez ID		4314	50859
HPRD ID		01703	12147
Ensembl ID		ENSG00000149968	ENSG00000196104
Uniprot IDs		P08254	A0A0A0MTJ2 B4DI52 Q9BQ16
PDB IDs		1B3D 1B8Y 1BIW 1BM6 1BQO 1C3I 1C8T 1CAQ 1CIZ 1CQR 1D5J 1D7X 1D8F 1D8M 1G05 1G49 1G4K 1HFS 1HY7 1OO9 1QIA 1QIC 1SLM 1SLN 1UEA 1UMS 1UMT 1USN 2D1O 2JNP 2JT5 2JT6 2SRT 2USN 3OHL 3OHO 3USN 4DPE 4G9L 4JA1 6MAV 6N9D 7S7L 7S7M	Not available
GO Terms Enriched among Interactors		Extracellular Space Extracellular Region Extracellular Matrix Regulation Of Cell Motility Regulation Of Locomotion Regulation Of Cell Migration Metalloendopeptidase Inhibitor Activity Cytokine Activity Eosinophil Chemotaxis Eosinophil Migration CCR Chemokine Receptor Binding Extracellular Matrix Binding Negative Regulation Of Cell Motility Negative Regulation Of Locomotion Perineuronal Net Leukocyte Migration Chemokine Activity Myeloid Leukocyte Migration Extracellular Matrix Structural Constituent Conferring Compression Resistance Leukocyte Chemotaxis Positive Regulation Of Leukocyte Migration Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Cell Migration Granulocyte Chemotaxis Positive Regulation Of Cell Migration Chemokine-mediated Signaling Pathway Positive Regulation Of Cell Motility Hyaluronic Acid Binding Monocyte Chemotaxis Positive Regulation Of Locomotion Cell Migration Cell Chemotaxis Granulocyte Migration Positive Regulation Of Mononuclear Cell Migration Regulation Of Leukocyte Migration Golgi Lumen Mononuclear Cell Migration Peptidase Inhibitor Activity CCR2 Chemokine Receptor Binding Cell Motility Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Regulation Of Mononuclear Cell Migration Astrocyte Cell Migration Negative Regulation Of Proteolysis Chemotaxis Negative Regulation Of Membrane Protein Ectodomain Proteolysis Antimicrobial Humoral Response Locomotion Enzyme Inhibitor Activity Skeletal System Development	Regulation Of Cell Motility Extracellular Matrix Organization Regulation Of Locomotion Extracellular Structure Organization Collagen Catabolic Process Extracellular Matrix Disassembly Extracellular Matrix Collagen Metabolic Process Endopeptidase Activity Metalloendopeptidase Activity Positive Regulation Of Mononuclear Cell Migration Positive Regulation Of Locomotion Cellular Response To Genistein Positive Regulation Of Cell Motility Negative Regulation Of GDF15-GFRAL Signaling Pathway Positive Regulation Of Deacetylase Activity Metallopeptidase Activity Serine-type Endopeptidase Activity Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Regulation Of Cell Migration Response To Odorant Response To Genistein Regulation Of Cell-substrate Adhesion Regulation Of Leukocyte Migration GDF15-GFRAL Signaling Pathway Response To Hydroxyisoflavone Macropinosome Release From Viral Latency Astrocyte Cell Migration CCR1 Chemokine Receptor Binding Response To Phenylpropanoid Negative Regulation Of Signal Transduction Cellular Response To UV-A Extracellular Space CAMP Response Element Binding Protein Binding Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To Oxidative Stress Cellular Response To Stress Response To UV-A Chondrocyte Proliferation Positive Regulation Of Myotube Differentiation Regulation Of Cell Growth Metalloendopeptidase Inhibitor Activity Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Induction Of Positive Chemotaxis Cellular Response To Nitric Oxide Peptidase Activity Cellular Response To Reactive Nitrogen Species