AFF1 and MLLT3

Number of citations: 62 (PubMedID 21729782)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo, two hybrid, in vitro)

		AFF1	MLLT3
Name		ALF transcription elongation factor 1	MLLT3 super elongation complex subunit
Structure
GO Annotations	Cellular Component	Nucleus Transcription Elongation Factor Complex Super Elongation Complex	Nucleus Nucleoplasm Chromosome Cytosol Transcription Elongation Factor Complex Extracellular Exosome
	Molecular Function	Protein Binding	DNA Binding Chromatin Binding Protein Binding Histone Binding Molecular Adaptor Activity Modification-dependent Protein Binding Histone H3K18ac Reader Activity Histone H3K9ac Reader Activity Histone H3K27ac Reader Activity
	Biological Process	Regulation Of Gene Expression	Chromatin Organization Segment Specification Anterior/posterior Pattern Specification Gene Expression Positive Regulation Of DNA-templated Transcription Hematopoietic Stem Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Chromatin Organization Regulation Of Stem Cell Division Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways		None	Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation
Diseases		Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)	None
GWAS		Alzheimer's disease (cognitive decline) ( 23535033 ) Apolipoprotein A1 levels ( 32203549 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 32888494 27863252 ) Bulimia nervosa ( 23568457 ) Diastolic blood pressure ( 28234671 ) Eyebrow thickness ( 26926045 ) HDL cholesterol levels ( 30698716 32203549 ) HDL cholesterol levels in current drinkers ( 30698716 ) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Heel bone mineral density ( 28869591 30598549 ) Hematocrit ( 27863252 32888494 29403010 ) Hematological and biochemical traits ( 31902109 ) Hemoglobin ( 32888494 29403010 ) Hemoglobin concentration ( 27863252 ) Hemoglobin levels ( 32327693 ) Lipoprotein (a) levels ( 33730874 ) Low density lipoprotein cholesterol levels ( 32154731 ) Lymphocyte count ( 32888494 ) Mean corpuscular hemoglobin ( 32888494 27863252 29403010 ) Mean corpuscular volume ( 32888494 27863252 29403010 ) Mean platelet volume ( 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Medication use (thyroid preparations) ( 31015401 ) Metabolic syndrome ( 31589552 ) Multiple sclerosis ( 31604244 ) PR interval ( 32439900 ) Red blood cell count ( 32888494 27863252 ) Refractive error ( 32231278 ) Systemic lupus erythematosus ( 22291604 ) Total bilirubin levels ( 29403010 ) Triglyceride levels ( 32154731 30698716 32203549 ) Triglyceride levels in current drinkers ( 30698716 ) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716 ) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535 ) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535 ) Triglycerides ( 30275531 20686565 20864672 25961943 ) White blood cell count (basophil) ( 27863252 29403010 )	Atrial fibrillation ( 29892015 ) Dietary fat liking ( 32516399 ) Estimated glomerular filtration rate ( 31152163 ) Glutathione peroxidase in non-alcoholic fatty liver disease x mastiha supplementation interaction ( 34025683 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Mean reticulocyte volume ( 32888494 ) Platelet distribution width ( 32888494 ) Response to montelukast in asthma (change in FEV1) ( 26083242 ) Systolic blood pressure ( 30578418 )
Interacting Genes		9 interacting genes: ARFIP1 H3-4 MLLT1 MLLT3 NT5E SASH1 SIAH1 SIAH2 SMAD9	18 interacting genes: AFF1 ALKBH4 APP APPBP2 BCOR CBX8 CDK6 EEF1A1 H3C1 LRIF1 LRRK2 MCM6 NRIP1 PTN RBM48 SGK1 VAX1 ZNF572
Entrez ID		4299	4300
HPRD ID		08871	01163
Ensembl ID		ENSG00000172493	ENSG00000171843
Uniprot IDs		B4DJU9 P51825 Q14C88	A0A0S2Z448 P42568
PDB IDs		2LM0	2LM0 2MV7 2N4Q 2NDF 2NDG 4TMP 5HJB 5HJD 5YYF 6B7G 6L5Z 6LS6 6MIL 6MIM 7EIC 7EID 7VKG 7VKH 8PJ7 8TLV 8TLW 8TLX 9ARO 9ARR
GO Terms Enriched among Interactors		Transcription Elongation Factor Complex Amyloid Fibril Formation Ubiquitin Conjugating Enzyme Binding	Cell Projection Morphogenesis Golgi-associated Vesicle Chromatin Organization Epigenetic Regulation Of Gene Expression Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Metabolic Process Neuron Projection Morphogenesis Regulation Of Gene Expression Negative Regulation Of Long-term Synaptic Potentiation Response To Auditory Stimulus Cellular Response To Catecholamine Stimulus Regulation Of Metabolic Process Cellular Response To Manganese Ion Response To Catecholamine Response To Manganese Ion Nucleoplasm Regulation Of Neuroblast Proliferation Neuron Projection Arborization Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Neuroblast Proliferation Nuclear Retinoic Acid Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process Nucleus Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Memory Molecular Function Activator Activity Negative Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of RNA Metabolic Process Chromatin Remodeling Amyloid-beta Complex Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Macromolecule Metabolic Process Dendrite Development Cyclin D2-CDK6 Complex Response To Polyamine Macromolecule Response To Reactive Oxygen Species Ovarian Follicle Rupture DNA N6-methyladenine Demethylase Activity Negative Regulation Of Tooth Mineralization BCOR Complex