ASAH1 and SMPD1

Number of citations: 0 (PubMedID 12815059)
Data Source: HPRD (in vitro)

		ASAH1	SMPD1
Name		N-acylsphingosine amidohydrolase 1	sphingomyelin phosphodiesterase 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Lysosome Early Endosome Endoplasmic Reticulum Membrane Lysosomal Lumen Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen	Extracellular Region Extracellular Space Lysosome Endosome Lipid Droplet Plasma Membrane Endolysosome Lamellar Body Lysosomal Lumen Extracellular Exosome
	Molecular Function	Transcription Corepressor Activity Protein Binding Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Nuclear Receptor Binding N-acylsphingosine Amidohydrolase Activity Fatty Acid Amide Hydrolase Activity	Sphingomyelin Phosphodiesterase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Phosphatidylcholine Phospholipase C Activity Metal Ion Binding Acid Sphingomyelin Phosphodiesterase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Sphingolipid Metabolic Process Keratinocyte Differentiation Negative Regulation Of DNA-templated Transcription Sphingosine Biosynthetic Process Ceramide Biosynthetic Process Ceramide Catabolic Process Regulation Of Steroid Biosynthetic Process Regulation Of Programmed Necrotic Cell Death Cellular Response To Tumor Necrosis Factor	Plasma Membrane Repair Lipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Signal Transduction Nervous System Development Cholesterol Metabolic Process Response To Xenobiotic Stimulus Response To Virus Response To Ionizing Radiation Termination Of Signal Transduction Cholesterol Efflux Response To Type I Interferon Response To Tumor Necrosis Factor Cellular Response To UV Wound Healing Response To Cocaine Positive Regulation Of Apoptotic Process Negative Regulation Of MAPK Cascade Positive Regulation Of Endocytosis Glycosphingolipid Catabolic Process Ceramide Biosynthetic Process Positive Regulation Of Viral Entry Into Host Cell Symbiont Entry Into Host Cell Pyroptotic Inflammatory Response Response To Interleukin-1 Cellular Response To Calcium Ion
Pathways		Neutrophil degranulation Glycosphingolipid catabolism Regulation of MITF-M-dependent genes involved in lysosome biogenesis and autophagy	Glycosphingolipid catabolism
Drugs		None	Amlodipine Chlorpromazine Desipramine Medical Cannabis
Diseases		Farber lipogranulomatosis; Farber disease	Niemann-Pick disease (NPD), including;; Niemann-Pick disease, type A; Niemann-Pick disease, type B
GWAS		Atrial fibrillation ( 28416818 29892015 30061737 ) Night sleep phenotypes ( 27126917 ) Obesity ( 21552555 ) Type 2 diabetes ( 32499647 )	Blood protein levels ( 30072576 ) Diisocyanate-induced asthma ( 25918132 ) Malaria ( 31844061 ) Neurological blood protein biomarker levels ( 31320639 )
Interacting Genes		6 interacting genes: CAMK1D HSPB2 SETDB1 SMPD1 SRPK1 TSC22D1	6 interacting genes: ANXA4 ANXA7 ASAH1 BEX3 DUSP23 NR1H2
Entrez ID		427	6609
HPRD ID		01969	06353
Ensembl ID		ENSG00000104763	ENSG00000166311
Uniprot IDs		A0A1B0GUE3 A8K0B6 Q13510 Q53H01	E9LUE8 E9LUE9 P17405 Q59EN6 Q8IUN0
PDB IDs		5U7Z 6MHM	5I81 5I85 5I8R 5JG8
GO Terms Enriched among Interactors		Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Phosphatidylcholine Phospholipase C Activity Regulation Of Viral Life Cycle Positive Regulation Of Apoptotic Process Acid Sphingomyelin Phosphodiesterase Activity Positive Regulation Of Viral Process Regulation Of Viral Process Termination Of Signal Transduction Somatic Muscle Development Positive Regulation Of Endocytosis Histone H3K9 Trimethyltransferase Activity Negative Regulation Of Hematopoietic Stem Cell Proliferation Negative Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Sphingomyelin Catabolic Process Lamellar Body Sphingomyelin Phosphodiesterase Activity Histone H3K9 Monomethyltransferase Activity Endolysosome Histone H3K9me2 Methyltransferase Activity Positive Regulation Of Respiratory Burst Positive Regulation Of CREB Transcription Factor Activity Histone H3K9 Methyltransferase Activity	Phosphatidylserine Binding Calcium-dependent Protein Binding Negative Regulation Of Cytokine-mediated Signaling Pathway Negative Regulation Of Macromolecule Metabolic Process Calcium-dependent Phospholipid Binding Epithelial Cell Differentiation Vesicle Membrane Negative Regulation Of Response To Cytokine Stimulus Positive Regulation Of Secretion Of Lysosomal Enzymes Negative Regulation Of Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Positive Regulation Of Pancreatic Juice Secretion Regulation Of High-density Lipoprotein Particle Assembly Regulation Of Cytokine-mediated Signaling Pathway Fatty Acid Amide Hydrolase Activity Regulation Of Lipid Biosynthetic Process N-acylsphingosine Amidohydrolase Activity Apolipoprotein A-I Receptor Binding Negative Regulation Of Pinocytosis Nerve Growth Factor Receptor Binding Negative Regulation Of Type II Interferon-mediated Signaling Pathway Nucleus Chromaffin Granule Membrane Negative Regulation Of Macromolecule Biosynthetic Process Cytoplasm Cell Differentiation Negative Regulation Of Biosynthetic Process Phospholipase Inhibitor Activity Negative Regulation Of Gene Expression Response To Phorbol 13-acetate 12-myristate Sphingoid Biosynthetic Process Sphingosine Biosynthetic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Positive Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Digestive System Process Regulation Of Type II Interferon-mediated Signaling Pathway Phosphatidylcholine Acyl-chain Remodeling Regulation Of Response To Type II Interferon Negative Regulation Of Cholesterol Storage Negative Regulation Of Macrophage Derived Foam Cell Differentiation Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Regulation Of Lipid Metabolic Process Zymogen Granule Membrane Nuclear Retinoid X Receptor Binding Death Receptor Binding Sphingosine Metabolic Process Ceramide Catabolic Process Regulation Of Triglyceride Biosynthetic Process Protein Tyrosine/serine/threonine Phosphatase Activity Negative Regulation Of DNA-templated Transcription