MGST1 and LTC4S

Number of citations: 0 (PubMedID 8954909)
Data Source: BioGRID (two hybrid), HPRD (in vitro, in vivo)

		MGST1	LTC4S
Name		microsomal glutathione S-transferase 1	leukotriene C4 synthase
Structure		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Outer Membrane Peroxisomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Membrane Azurophil Granule Membrane	Nucleus Nuclear Envelope Nuclear Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Nuclear Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Glutathione Transferase Activity Glutathione Peroxidase Activity Protein Binding Transferase Activity	Glutathione Transferase Activity Leukotriene-C4 Synthase Activity Glutathione Peroxidase Activity Protein Binding Enzyme Activator Activity Lipid Binding Transferase Activity Lyase Activity Identical Protein Binding
	Biological Process	Glutathione Transport Cellular Response To Lipid Hydroperoxide Cellular Oxidant Detoxification	Lipid Metabolic Process Leukotriene Metabolic Process Leukotriene Biosynthetic Process Long-chain Fatty Acid Biosynthetic Process Carboxylic Acid Biosynthetic Process Cellular Oxidant Detoxification
Pathways		Glutathione conjugation Aflatoxin activation and detoxification Neutrophil degranulation	Synthesis of 5-eicosatetraenoic acids Synthesis of Leukotrienes (LT) and Eoxins (EX) Biosynthesis of Lipoxins (LX) Biosynthesis of maresin conjugates in tissue regeneration (MCTR) Biosynthesis of protectin and resolvin conjugates in tissue regeneration (PCTR and RCTR)
Drugs		Glutathione Glutathione disulfide	Glutathione Azelastine
GWAS		Barrett's esophagus or Esophageal adenocarcinoma ( 32918910 ) Barrett's esophagus or esophageal adenocarcinoma x sex interaction (2df test) ( 32918910 ) Bell's palsy ( 33602968 ) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442 ) Household income (MTAG) ( 31844048 ) Metabolite levels ( 23823483 ) Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699 ) Mild age-related type 2 diabetes ( 34737425 ) Visceral fat ( 22589738 )	No GWAS studies recorded
Interacting Genes		8 interacting genes: EGF FXYD3 FZD7 LTC4S NELFB SIGLEC12 TNFRSF10C VIP	12 interacting genes: ALOX5 ALOX5AP CD79A CREB3L1 EBP FFAR3 FXYD3 GPR152 GPR42 MGST1 SLC7A14 TMEM52B
Entrez ID		4257	4056
HPRD ID		00705	02004
Ensembl ID		ENSG00000008394	ENSG00000213316
Uniprot IDs		F5H613 P10620	Q16873
PDB IDs		Not available	2PNO 2UUH 2UUI 3B29 3HKK 3LEO 3PCV 4BPM 4J7T 4J7Y 4JC7 4JCZ 4JRZ 4WAB 5HV9 6R7D 9G0U 9G0V 9G14 9G1T
GO Terms Enriched among Interactors		None	Leukotriene Production Involved In Inflammatory Response Arachidonate Metabolite Production Involved In Inflammatory Response Membrane Production Of Molecular Mediator Involved In Inflammatory Response Leukotriene Biosynthetic Process Glutathione Peroxidase Activity Negative Regulation Of Sprouting Angiogenesis Glutathione Transferase Activity Leukotriene Metabolic Process Leukotriene A4 Biosynthetic Process Arachidonate 5-lipoxygenase Activity Nuclear Envelope Negative Regulation Of Response To Endoplasmic Reticulum Stress Icosanoid Biosynthetic Process Endoplasmic Reticulum Membrane Cellular Response To Lipid Hydroperoxide Cholesterol-5,6-oxide Hydrolase Activity Regulation Of Sprouting Angiogenesis Nuclear Membrane Leukotriene A4 Metabolic Process Arachidonate 8(S)-lipoxygenase Activity Positive Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus C-8 Sterol Isomerase Activity Cholestenol Delta-isomerase Activity Cellular Oxidant Detoxification Regulation Of Response To Endoplasmic Reticulum Stress Lipoxin Biosynthetic Process Arachidonate 12(S)-lipoxygenase Activity Positive Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell IgM B Cell Receptor Complex Response To Lipid Hydroperoxide Cholesterol Biosynthetic Process Via Lathosterol Cholesterol Biosynthetic Process Via Desmosterol Steroid Delta-isomerase Activity Extracellular Matrix Constituent Secretion Icosanoid Metabolic Process G Protein-coupled Receptor Activity Oxidoreductase Activity, Acting On Single Donors With Incorporation Of Molecular Oxygen Cellular Detoxification B Cell Receptor Complex Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Epoxide Metabolic Process Endoplasmic Reticulum Leukotriene-C4 Synthase Activity Small Molecule Biosynthetic Process Negative Regulation Of Vasculature Development Negative Regulation Of Angiogenesis Arachidonate Binding Gamma-aminobutyric Acid Import Gamma-aminobutyric Acid Transmembrane Transporter Activity