MDFI and HTR1B

Number of citations: 69 (PubMedID 24722188)
Data Source: BioGRID (two hybrid, two hybrid, two hybrid)

		MDFI	HTR1B
Name		MyoD family inhibitor	5-hydroxytryptamine receptor 1B
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cytoplasm Endoplasmic Reticulum Plasma Membrane Membrane Dendrite Presynaptic Membrane G Protein-coupled Serotonin Receptor Complex Serotonergic Synapse
	Molecular Function	Protein Binding Identical Protein Binding Protein Sequestering Activity Transcription Regulator Inhibitor Activity	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Serotonin Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Dorsal/ventral Axis Specification Regulation Of Gene Expression Regulation Of Wnt Signaling Pathway Cell Differentiation Negative Regulation Of Wnt Signaling Pathway Maintenance Of Protein Location In Cell Negative Regulation Of DNA-templated Transcription Regulation Of JNK Cascade Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Negative Regulation Of Serotonin Secretion Vasoconstriction Bone Remodeling Regulation Of Behavior Cellular Response To Alkaloid Cellular Response To Xenobiotic Stimulus Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation
Pathways		None	Serotonin receptors G alpha (i) signalling events
Drugs		None	Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Dihydroergotamine Amitriptyline Olanzapine Clozapine Loxapine Amoxapine Propranolol Lisuride Sumatriptan Ergotamine Apomorphine Paroxetine Ondansetron Almotriptan Oxymetazoline Naratriptan Rizatriptan Pindolol Frovatriptan Ergoloid mesylate Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Penbutolol Yohimbine Dapoxetine NXN-188 Pizotifen Asenapine Nandrolone decanoate Bopindolol Vortioxetine Setiptiline Dihydroergocornine Gilteritinib Lecozotan Tiapride Dihydroergocristine Aripiprazole lauroxil
GWAS		Grapefruit juice consumption ( 31046077 ) Subjective response to placebo treatment in childhood asthma (change in cough/wheeze) ( 31557306 )	Brain volume in infants (white matter) ( 28763065 ) Early chronic obstructive pulmonary disease in never smokers ( 33235445 ) HDL cholesterol levels in HIV infection ( 33109212 ) Psychological distress ( 30705256 ) Response to fenofibrate (total cholesterol levels) ( 27002377 )
Interacting Genes		405 interacting genes: AANAT AASDHPPT ABCF3 ABHD11 ABHD17A ADAMTSL3 ADRA2C AEBP2 AGXT AKAP17A ANKRD13C-DT AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ARMC7 ATG12 ATN1 ATOSB ATP5F1D ATP6V0C ATXN7L2 AVPI1 AXIN1 B3GNT9 BAALC BAG3 BAHD1 BANP BBS2 BCAM BCL6 BCL6B BEX1 BEX2 BEX3 C10orf62 C1orf216 C22orf39 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBLL2 CBX2 CBX8 CC2D1B CCDC116 CCDC120 CCDC185 CCDC187 CCDC198 CCDC33 CCER1 CCNL2 CDC20B CDC37 CDC42EP1 CDCA7L CDKL3 CEP57L1 CFAP206 CHIC2 CHP2 CHRNG CIMAP1B CLPB CNNM3 CRACR2A CREB5 CRH CRX CRY1 CSNK1G2-AS1 CSNK1G3 CTRC CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNAJB13 DNMT3A DNPEP DOCK2 DOK3 DUSP6 DYNLT4 EBI3 EFEMP2 EIF4A2 EIF4E2 ELOA ENKD1 ETNK2 EWSR1 FAAP100 FADS6 FAM120AOS FAM124B FAM161A FAM161B FAM27E3 FAM90A1 FARS2 FASTK FBXL18 FBXO34 FBXW5 FES FEZF1 FNDC11 FOXD4 FOXD4L1 FOXD4L3 FOXD4L6 FZD9 GABRD GATA1 GATA2 GDF15 GLIDR GLRX3 GNAI2 GNE GNG5 GPANK1 GPATCH2L GPRIN2 GREM1 GTF3C5 HAPLN2 HASPIN HEYL HHEX HNRNPLL HOXA1 HOXB9 HPCAL1 HTR1B HYPK IFRD2 ILF3 INTS11 IQUB ITGB4 JOSD1 KANSL1 KAT5 KCTD7 KIAA0040 KIAA0408 KIF1A KLHL38 KPNA2 KRAS KRT77 LAMB3 LASP1 LCE1A LCE1B LCE1D LCE1F LCE2B LCE3A LCE3C LCE3D LCE3E LCE4A LIMS2 LIN7A LINC00636 LINC01588 LMO3 LRCH4 LRRN4 MACIR MAGEC3 MAGED1 MAGEF1 MAPK1 MAPKBP1 MBD1 MBD3L2 MCM5 MEOX2 METTL17 MGAT5B MRPL20-AS1 MVP MXI1 MYF5 MYOD1 MYOG MYPOP NAB2 NDUFA7 NECTIN2 NEU4 NIBAN3 NKD1 NOL4L-DT NPDC1 NPEPL1 NR1H2 NR1H3 NSD1 NTAQ1 NUBP2 NUFIP2 ODAD4 ODAPH ODF1 OLIG3 OTX1 PARP11 PATZ1 PBXIP1 PCSK5 PDGFA PDGFB PDIA5 PDS5A PELI2 PGLS PHF1 PHLDA1 PIBF1 PID1 PIDD1 PIH1D2 PIN1 PKD2 PLEKHG4 POLL POM121L8P PRKAB2 PRPF18 PRPF31 PRR34 PTK7 PTPMT1 RABL6 RAC1 RASD1 REG3A REX1BD RFX2 RHOXF2 RIN1 RIPPLY1 RNF111 RNF6 RTP5 SAPCD2 SCAMP4 SCNM1 SELENOM SEMA3B SERF2 SFI1 SHFL SHMT1 SIX1 SLC13A5 SLC15A3 SLC25A10 SLC33A2 SLC35A2 SLC35D4 SLC9A1 SMYD1 SNX18 SOCS7 SPATA24 SPATA3 SPATA8 SPG7 SPMAP2 SPMIP2 SPON1 SPRED2 SPRY1 SPRY2 SUOX TACO1 TAP1 TASOR2 TBC1D3B TBC1D3G TCEANC TCF3 TEAD4 TEDC2 TGIF1 TH THAP7 TIE1 TINAGL1 TLE5 TMIE TNNI1 TNP2 TOR1A TRAF3IP2 TRIB3 TRPC1 TRPV6 TSC2 TSFM TSGA10IP TSPAN4 TSPYL1 TSPYL6 TTC23 TTLL10 TUSC2 TXN2 TYMSOS TYRO3 USP20 USP6 VASN VGLL3 VHL VPS72 VSTM4 WDFY3 WNT11 YPEL3 YY1 ZBBX ZBTB24 ZBTB25 ZBTB42 ZBTB9 ZC3HAV1 ZDHHC1 ZFYVE26 ZIM2 ZNF101 ZNF12 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF221 ZNF223 ZNF23 ZNF230 ZNF264 ZNF266 ZNF330 ZNF408 ZNF414 ZNF417 ZNF426 ZNF433 ZNF438 ZNF439 ZNF440 ZNF441 ZNF446 ZNF461 ZNF479 ZNF490 ZNF491 ZNF497 ZNF512B ZNF524 ZNF559 ZNF564 ZNF572 ZNF575 ZNF578 ZNF580 ZNF581 ZNF587 ZNF607 ZNF613 ZNF646 ZNF648 ZNF662 ZNF669 ZNF670 ZNF679 ZNF688 ZNF696 ZNF707 ZNF764 ZNF784 ZNF785 ZNF786 ZNF79 ZNF837 ZNF844 ZNHIT1	5 interacting genes: ACTN2 HTR1A HTR1D MDFI SNCA
Entrez ID		4188	3351
HPRD ID		07280	01634
Ensembl ID		ENSG00000112559	ENSG00000135312
Uniprot IDs		B1AKB6 Q99750	A8K215 P28222 X5D7I5
PDB IDs		Not available	4IAQ 4IAR 5V54 6G79 7C61
GO Terms Enriched among Interactors		Protein Binding DNA Binding Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Biosynthetic Process RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of RNA Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Zinc Ion Binding Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Nucleus Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Regulation Of Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Metal Ion Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Keratinization Sequence-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Lens Fiber Cell Differentiation Negative Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific	Gi/o-coupled Serotonin Receptor Activity G Protein-coupled Serotonin Receptor Activity Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Activity Regulation Of Dopamine Metabolic Process Neurotransmitter Receptor Activity G Protein-coupled Serotonin Receptor Signaling Pathway Synapse Chemical Synaptic Transmission Protein Sequestering Activity Trans-synaptic Signaling Synaptic Signaling G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Monoatomic Ion Transport Regulation Of Behavior Actin Filament Uncapping Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phenol-containing Compound Metabolic Process Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Cell-cell Signaling Positive Regulation Of Cation Transmembrane Transport Signaling Titin Z Domain Binding Positive Regulation Of Monoatomic Ion Transmembrane Transport Cell Communication Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Phospholipase C-activating Angiotensin-activated Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Blood Vessel Diameter Maintenance Regulation Of Tube Size Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy G Protein-coupled Receptor Signaling Pathway Microspike Assembly Positive Regulation Of Monoatomic Ion Transport Receptor-receptor Interaction Intestine Smooth Muscle Contraction Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake FATZ Binding Regulation Of Serotonin Secretion Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process