MCM5 and CDC5L

Number of citations: 28 (PubMedID 20467437)
Data Source: BioGRID (affinity chromatography technology, pull down), HPRD (in vitro)

		MCM5	CDC5L
Name		minichromosome maintenance complex component 5	cell division cycle 5 like
Structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Chromosome Membrane MCM Complex CMG Complex	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Spliceosomal Complex Cytoplasm Membrane Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome
	Molecular Function	Nucleotide Binding DNA Binding DNA Replication Origin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding RNA Binding Protein Binding Protein Domain Specific Binding Identical Protein Binding WD40-repeat Domain Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation Regulation Of DNA-templated DNA Replication Initiation	DNA Damage Checkpoint Signaling MRNA Splicing, Via Spliceosome DNA Repair Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing DNA Damage Response RNA Splicing Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state Regulation of MITF-M-dependent genes involved in DNA replication, damage repair and senescence	mRNA Splicing - Major Pathway
GWAS		Chronotype ( 30696823 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Alzheimer disease and age of onset ( 26830138 ) Chin dimples ( 27182965 ) Femoral neck bone mineral density and trunk fat mass adjusted by trunk lean mass ( 32239398 ) FEV1 ( 30804560 ) Height ( 28552196 ) Ischemic stroke ( 26089329 ) Lung function (FVC) ( 30804560 ) Male-pattern baldness ( 27182965 ) Monobrow ( 27182965 ) Nose morphology ( 29921221 ) Ossification of the posterior longitudinal ligament of the spine ( 25064007 ) Osteoarthritis ( 22763110 ) Osteoarthritis of the hand ( 28855172 ) Serum alkaline phosphatase levels ( 33547301 ) Stroke (ischemic) ( 22941190 ) Trunk fat mass adjusted for trunk lean mass ( 32239398 )
Interacting Genes		30 interacting genes: APP ATRIP CDC5L CDC7 CDKN2A CEBPA EP300 ESCO2 FBXO7 KRTAP10-7 LMNA MCM2 MCM3 MCM7 MCMBP MCPH1 MDFI NFKBIA NUDT3 ORC1 ORC2 ORC3 ORC5 ORC6 PTEN RBPMS RPA2 STAT1 TRIM28 YWHAG	92 interacting genes: AKAP6 AKAP9 ANXA1 BICRAL CALM1 CCDC136 CDC42 CDK2 CDKN1A CDKN2A CDT1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HNRNPM HOOK1 KALRN KANK2 KANSL1 KIF3C KIF5B KRT18 LDOC1 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MIR106B MIR107 MIR143 MIR200B MIR214 MIR25 MIR31 MIR34A MIR34B MIR363 MIR429 MIRLET7A2 MIRLET7D MIRLET7E MIRLET7G MIRLET7I MTUS2 MYT1L OGT ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF3 RNF10 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 SYNPO TP53BP2 TRAF3IP1 TRAK1 TRIO TTF2 TXLNA USHBP1 USP7 VPS52 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1
Entrez ID		4174	988
HPRD ID		04075	04184
Ensembl ID		ENSG00000100297	ENSG00000096401
Uniprot IDs		B1AHB0 P33992	Q99459
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	2DIM 2DIN 5MQF 5XJC 5YZG 5Z56 5Z57 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6ZYM 7A5P 7AAV 7ABG 7ABH 7ABI 7DVQ 7QTT 7W59 7W5A 7W5B 8C6J 8CH6 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8RO2 9FMD
GO Terms Enriched among Interactors		DNA Replication Initiation Nuclear Origin Of Replication Recognition Complex DNA Replication Origin Recognition Complex DNA Metabolic Process Nucleoplasm Nucleic Acid Metabolic Process DNA Replication Origin Binding Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA Metabolic Process Chromosome, Telomeric Region Regulation Of DNA Replication Nucleobase-containing Compound Metabolic Process MCM Complex Double-strand Break Repair Via Break-induced Replication Regulation Of Primary Metabolic Process Cellular Response To Stress Macromolecule Metabolic Process Response To Stress Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Cell Cycle DNA Repair Regulation Of Protein Localization To Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition CMG Complex Regulation Of Cell Cycle Chromatin Double-strand Break Repair Negative Regulation Of Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle Process DNA Binding Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair Via Homologous Recombination Single-stranded DNA Helicase Activity Recombinational Repair Negative Regulation Of Cell Cycle Process Protein Localization To Organelle Mitotic DNA Replication Initiation Identical Protein Binding Regulation Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction NF-kappaB Binding Regulation Of Protein Stability Single-stranded DNA Binding Negative Regulation Of DNA-templated Transcription	MRNA Base-pairing Post-transcriptional Repressor Activity MiRNA-mediated Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Post-transcriptional Gene Silencing Post-transcriptional Gene Silencing Regulatory NcRNA-mediated Gene Silencing RISC Complex DNA Replication Initiation Post-transcriptional Regulation Of Gene Expression Regulation Of DNA-templated DNA Replication Initiation DNA Replication Origin Binding MRNA 3'-UTR Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression DNA Replication Negative Regulation Of Biosynthetic Process MiRNA-mediated Gene Silencing By Inhibition Of Translation Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process MiRNA-mediated Gene Silencing By MRNA Destabilization Regulation Of G1/S Transition Of Mitotic Cell Cycle Regulation Of Macromolecule Metabolic Process Negative Regulation Of Developmental Process Origin Recognition Complex Regulation Of DNA Replication Positive Regulation Of Tissue Remodeling Chromosome, Telomeric Region Regulation Of Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Translation Extracellular Vesicle Nuclear Origin Of Replication Recognition Complex Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoskeleton CMG Complex MCM Complex Negative Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Connective Tissue Replacement Double-strand Break Repair Via Break-induced Replication Negative Regulation Of Transmembrane Transport Regulation Of Cell Cycle Glutamatergic Synapse Regulation Of Connective Tissue Replacement Molecular Adaptor Activity Microtubule Binding Negative Regulation Of Protein Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Microtubule Cytoskeleton-dependent Intracellular Transport Negative Regulation Of Protein-containing Complex Assembly