MCL1 and BOK

Number of citations: 48 (PubMedID 9356461)
Data Source: HPRD (two hybrid)

		MCL1	BOK
Name		MCL1 apoptosis regulator, BCL2 family member	BCL2 family apoptosis regulator BOK
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Bcl-2 Family Protein Complex	Nucleus Nuclear Outer Membrane Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Early Endosome Membrane Mitochondrial Membrane Trans-Golgi Network Membrane Cis-Golgi Network Membrane Recycling Endosome Membrane
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Channel Activity Protein Heterodimerization Activity BH Domain Binding BH3 Domain Binding	Signaling Receptor Binding Protein Binding Channel Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Protein-containing Complex Binding Protein Heterodimerization Activity Protein Dimerization Activity BH Domain Binding
	Biological Process	Cell Fate Determination Release Of Cytochrome C From Mitochondria Apoptotic Process DNA Damage Response Mitochondrial Fusion Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Autophagy Cellular Homeostasis Cell Differentiation Response To Cytokine Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Transmembrane Transport Protein Transmembrane Transport Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Intracellular Signal Transduction Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Anoikis Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Release Of Cytochrome C From Mitochondria Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Autophagy Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Protein Complex Oligomerization Neuron Apoptotic Process Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Mitochondrial Depolarization Transmembrane Transport Negative Regulation Of Necroptotic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Response To Cisplatin Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Chorionic Trophoblast Cell Proliferation Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of PERK-mediated Unfolded Protein Response Regulation Of Granulosa Cell Apoptotic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Interleukin-4 and Interleukin-13 signaling Signaling by ALK fusions and activated point mutants	None
GWAS		Blood protein levels ( 30072576 ) Coffee consumption ( 31959922 ) Coronary artery disease ( 29212778 ) Eosinophil count ( 27863252 ) FEV1 ( 30804560 ) Lung function (FEV1) ( 26635082 ) Lung function (FVC) ( 26635082 30804560 ) Mean corpuscular hemoglobin ( 32888494 ) Melanoma ( 21983785 ) Monocyte count ( 29403010 ) Multiple sclerosis ( 31604244 ) Refractive error ( 32231278 ) Rhegmatogenous retinal detachment ( 23585552 ) Sum eosinophil basophil counts ( 27863252 ) White matter hyperintensity volume ( 33293549 ) White matter hyperintensity volume (adjusted for hypertension) ( 33293549 ) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549 )	Appendicular lean mass ( 33097823 ) Brain structure ( 20171287 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 31562340 ) Hip circumference adjusted for BMI ( 34021172 ) Planum temporale asymmetry index ( 31887566 ) Prostate cancer ( 23535732 ) Thyroid stimulating hormone levels ( 32769997 )
Interacting Genes		40 interacting genes: APEX1 BAD BAK1 BAX BBC3 BCL2L1 BCL2L11 BID BIK BMF BOK BTRC CASP3 CDC20 CHRM4 DAD1 FBXW11 GSK3A GSK3B HIF1A HRK HUWE1 KCNF1 MAPK1 MAPK10 PCNA PIN1 PMAIP1 SIRT1 SIRT2 SIRT3 STX8 TNKS TPT1 TRAF6 TRIM11 UBXN6 UHRF2 USP9X VDAC1	3 interacting genes: BCL2A1 MCL1 NOA1
Entrez ID		4170	666
HPRD ID		08870	05657
Ensembl ID		ENSG00000143384	ENSG00000176720
Uniprot IDs		A0A087WT64 C8YZ26 Q07820	A0A024R4A8 A0A481T0W6 A0A4D6NU76 Q9UMX3
PDB IDs		2KBW 2MHS 2NL9 2NLA 2PQK 3D7V 3IO9 3KJ0 3KJ1 3KJ2 3KZ0 3MK8 3PK1 3TWU 3WIX 3WIY 4BPI 4BPJ 4HW2 4HW3 4HW4 4OQ5 4OQ6 4WGI 4WMR 4WMS 4WMT 4WMU 4WMV 4WMW 4WMX 4ZBF 4ZBI 5C3F 5C6H 5FC4 5FDO 5FDR 5IEZ 5IF4 5JSB 5KU9 5LOF 5MES 5MEV 5UUM 5VKC 5VX2 5W89 5W8F 6B4L 6B4U 6BW2 6BW8 6FS0 6FS1 6FS2 6MBD 6MBE 6NE5 6O4U 6O6F 6O6G 6OQB 6OQC 6OQD 6OQN 6OVC 6P3P 6QB3 6QB4 6QB6 6QFC 6QFI 6QFM 6QFQ 6QGD 6QXJ 6QYK 6QYL 6QYN 6QYO 6QYP 6QZ5 6QZ6 6QZ7 6QZ8 6QZB 6STJ 6U63 6U64 6U65 6U67 6U6F 6UA3 6UAB 6UD2 6UDI 6UDT 6UDU 6UDV 6UDX 6UDY 6VBX 6YBG 6YBJ 6YBK 6YBL 6ZIE 7NB4 7NB7 7XGE 8AV9 8EKX 8EL0 8EL1 8G3S 8G3T 8G3U 8G3W 8G3X 8G3Y 8H7B 8IQM 8QSO 8SVY 8T6F 8VJP 8Y1Y 8Y1Z 8Y20 9BCG 9CKN	6CKV
GO Terms Enriched among Interactors		Regulation Of Mitochondrion Organization Positive Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Mitochondrial Membrane Permeability Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Release Of Cytochrome C From Mitochondria Apoptotic Mitochondrial Changes Regulation Of Membrane Permeability Regulation Of Apoptotic Process Positive Regulation Of Organelle Organization Regulation Of Programmed Cell Death Regulation Of Organelle Organization Cellular Response To Stress Bcl-2 Family Protein Complex Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Apoptotic Signaling Pathway Apoptotic Process Programmed Cell Death Cell Death Mitochondrial Membrane Organization Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Membrane Permeability Regulation Of Intrinsic Apoptotic Signaling Pathway Mitochondrion Organization Positive Regulation Of Membrane Permeability DNA Damage Response Mitochondrial Outer Membrane Regulation Of Autophagy Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Intrinsic Apoptotic Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Cell Communication Regulation Of Intracellular Signal Transduction Positive Regulation Of Signaling Regulation Of Cellular Response To Stress Regulation Of Neuron Apoptotic Process Mitochondrion Leukocyte Apoptotic Process Positive Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Response To Endoplasmic Reticulum Stress Response To Stress Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Signal Transduction Organelle Organization Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Cellular Component Organization	Release Of Cytochrome C From Mitochondria Mitochondrion Organization Mitochondrial Fusion Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Channel Activity Apoptotic Mitochondrial Changes Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Cell Death Programmed Cell Death Extrinsic Apoptotic Signaling Pathway Apoptotic Process Organelle Fusion Intrinsic Apoptotic Signaling Pathway Mitochondrial Outer Membrane BH Domain Binding Positive Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway BH3 Domain Binding Matrix Side Of Mitochondrial Inner Membrane Mitochondrial Ribosome Assembly Positive Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Bcl-2 Family Protein Complex Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Organelle Organization Negative Regulation Of Anoikis Ribosome Assembly Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Anoikis Protein Transmembrane Transporter Activity DNA Damage Response Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Apoptotic Process Cell Fate Determination Negative Regulation Of Programmed Cell Death Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Transmembrane Transport Positive Regulation Of Neuron Apoptotic Process Protein Transmembrane Transport Negative Regulation Of Extrinsic Apoptotic Signaling Pathway