MCC and NFKBIB

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		MCC	NFKBIB
Name		MCC regulator of Wnt signaling pathway	NFKB inhibitor beta
Structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Lamellipodium Cell Projection	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding Signaling Receptor Activity	Transcription Coactivator Activity Protein Binding
	Biological Process	Signal Transduction Negative Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Establishment Of Protein Localization Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway	DNA-templated Transcription Inflammatory Response Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of DNA-templated Transcription Cellular Response To Lipopolysaccharide
Pathways		None	Activation of NF-kappaB in B cells RIP-mediated NFkB activation via ZBP1 TAK1-dependent IKK and NF-kappa-B activation TRAF6 mediated NF-kB activation
GWAS		Adult body size ( 32376654 ) Brain cytoarchitecture ( 20308991 ) Cerebral amyloid angiopathy ( 25188341 ) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189 ) Femur bone mineral density x serum urate levels interaction ( 34046847 ) Height ( 31562340 ) Metabolite levels ( 23823483 ) Neurofibrillary tangles ( 31497858 ) Nicotine dependence symptom count ( 25555482 ) Triglyceride levels ( 32203549 ) Waist circumference adjusted for body mass index ( 34021172 )	Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 )
Interacting Genes		77 interacting genes: ALDOB ANP32B APP BAAT C8orf33 C8orf48 CBX5 CBX8 CCDC112 CCDC146 CCDC180 CCDC185 CCDC187 CDC14B CDK8 CDKL3 CEP57L1 CEP95 CFAP58 CYLC2 DNAAF4 DYNC1I1 ELOA ERBIN ESRRG FAM161A FGF16 FRAT2 GTF2E2 HEMGN HSD17B3 KAT5 KEAP1 KIF3C KIFC3 LRRC45 MSANTD3 MTNR1A NANS NEK2 NFKBIB NOL12 PCCA PNKP POLL PRPF18 RASAL2 RCOR3 SEC61B SFRP4 SLTM SLU7 SYT17 SYT6 TCEA2 TCEANC TGFB1 THAP7 TRMO TRMT2A TSHZ2 TSTD2 TXLNA UTP14C ZBTB48 ZNF12 ZNF189 ZNF202 ZNF264 ZNF3 ZNF35 ZNF417 ZNF438 ZNF497 ZNF543 ZNF648 ZNF792	43 interacting genes: APP BAK1 BTBD6 BTRC CDC25A CHUK CSNK2A1 CUL1 DNAJA3 ESR2 FHL3 GIT2 IKBKB IKBKG KPNA2 LRPPRC MCC MTIF2 NCOR2 NDUFB7 NFKB1 NFKB2 NFKBIA NGFR NKIRAS1 NKIRAS2 PDCD2 POLR1A POLR1B POLR1C POLR1D POLR1E POLR1G POLR2H POLR2L PPARG RASAL2 REL RELA RXRA SKP1 TSPAN1 VPS52
Entrez ID		4163	4793
HPRD ID		01157	07260
Ensembl ID		ENSG00000171444	ENSG00000104825
Uniprot IDs		P23508	G5E9C2 Q15653
PDB IDs		6MTU 6MTV	9CK0
GO Terms Enriched among Interactors		Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Centrosome	RNA Polymerase I Complex Non-canonical NF-kappaB Signal Transduction DNA-directed RNA Polymerase Complex Canonical NF-kappaB Signal Transduction Nucleoplasm DNA-directed RNA Polymerase Activity Intracellular Signal Transduction Regulation Of Canonical NF-kappaB Signal Transduction Transcription By RNA Polymerase I DNA-templated Transcription Intracellular Signaling Cassette Negative Regulation Of Canonical NF-kappaB Signal Transduction I-kappaB/NF-kappaB Complex Cytosol Regulation Of Intracellular Signal Transduction RNA Polymerase III Complex Regulation Of MiRNA Metabolic Process Negative Regulation Of Signal Transduction Nucleobase-containing Compound Biosynthetic Process Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Cell Communication RRNA Transcription Tumor Necrosis Factor-mediated Signaling Pathway IkappaB Kinase Complex Negative Regulation Of MiRNA Transcription Regulation Of Signal Transduction Nucleus DNA Binding Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Transferrin Receptor Binding Signal Transduction Involved In Regulation Of Gene Expression Immune Response-activating Cell Surface Receptor Signaling Pathway RNA Metabolic Process Cellular Response To Tumor Necrosis Factor Negative Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Cell Communication Regulation Of Signaling Regulation Of DNA-binding Transcription Factor Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway NF-kappaB P50/p65 Complex Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Response To Cytokine Response To Peptide Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process Response To Tumor Necrosis Factor Positive Regulation Of T Cell Receptor Signaling Pathway